Increased radiosensitivity is associated with p53 mutations in cell lines derived from oral cavity carcinoma

Acta Oto-Laryngologica

Volumn 116, Issue 2, 1996, Pages 341-344

  Pekkola Heino, Kirsi ^a   Servomaa, Kristina ^b   Kiuru, Anne ^b   Grenman, Reidar ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b STUK RADIATION AND NUCLEAR SAFETY AUTHORITY   (Finland)

Author keywords

Head and neck cancer; Radiotherapy; Tumor suppressor gene

Indexed keywords

ARTICLE; CELL LINE; HUMAN; HUMAN CELL; MOUTH CARCINOMA; MUTATION; PRIORITY JOURNAL; RADIOSENSITIVITY;

EID: 0029981574     PISSN: 00016489     EISSN: None     Source Type: Journal    
DOI: 10.3109/00016489609137854     Document Type: Article

References (25)

1. Jung M, Notario V, Dritschilo A. Mutations in the p53 gene in radiation-sensitive and -resistant human squamous carcinoma cells. Cancer Res 1992; 52: 6390-3.
2. Brachman DG, Beckett M, Graves D, Haraf D, Vokes E, Weichselbaum RR. p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cell lines. Cancer Res 1993; 53: 3667-9.
3. Lee JM, Bernstein A. p53 mutations increase resistance to ionizing radiation. Proc Natl Acad Sci USA 1993; 90: 5742-6.
4. Clarke AR, Purdie CA, Harrison DJ, et al. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 1993; 362: 849-52.
5. Biard DSF, Martin M, Le Rhun Y, et al. Concomitant p53 gene mutation and increased radiosensitivity in rat lung embryo epithelial cells during neoplastic development. Cancer Res 1994; 54: 3361-4.
6. Lowe SW, Bodis S, McClathey A, et al. p53 status and the efficacy of cancer therapy in vivo. Science 1994; 266: 807-10.
7. McIlwrath AJ, Vasey PA, Ross GM, Brown R. Cell cycle arrests and radiosensitivity of human tumor cell lines: dependence on wild-type p53 for radiosensitivity. Cancer Res 1994; 54: 3718-22.
8. Merritt AJ, Potten CS, Kemp CJ, et al. The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res 1994; 54: 614-7.
9. Wattel E, Preudhomme C, Hecquet B, et al. p53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies. Blood 1994; 84: 3148-57.
10. Servomaa K, Kiuru A, Grénman R, Pekkola-Heino K, Pulkkinen JO, Rytömaa T. p53 mutations associated with increased sensitivity to ionizing radiation in human head and neck cancer cell lines. (Submitted).
11. Grénman R, Pekkola-Heino K, Joensuu H, Aitasalo K, Klempi P, Lakkala T. UT-MUC-1, a new mucoepidermoid carcinoma cell line and its radiosensitivity. Arch Otolaryngol Head Neck Surg 1992: 118: 542-7.
12. Pekkola-Heino K, Kulmala J, Klemi P, et al. Effects of radiation fractionation on four squamous cell carcinoma cell lines with dissimilar inherent radiation sensitivity. J Cancer Res Clin Oncol 1991; 117: 597-602.
13. Pekkola-Heino K, Joensuu H, Klemi P, Grénman R. Relation of DNA ploidy and proliferation rate to radiation sensitivity in squamous cell carcinoma cell lines. Arch Otolaryngol Head Neck Surg 1994; 120: 750-4.
14. Grénman R, Burk D, Virolainen E, et al. Clonogenic cell assay for anchorage-dependent squamous carcinoma cell lines using limiting dilution. Int J Cancer 1989; 44: 131-6.
15. Fertil B, Detinger H, Courdi A, Malaise P. Mean inac tivation dose a useful concept for intercomparison of human cell survival curves. Radiat Res 1984; 99: 73-84.
16. Finnish Cancer Registry, 1993.
17. Peters LJ. Inherent radiosensitivity of tumor and normal tissue cells as a predictor of human tumor response. Radiother Oncol 1990; 17: 177-90.
18. Weichselbaum RR, Rotmensch J, Ahmed-Swan S, Beckett MA. Radiobiological characterization of 53 human tumor cell lines. Int J Radiat Biol 1989; 56: 553-60.
19. Grénman R, Carey TE, McClatchey KD, et al. In vitro radiation resistance among cell lines established from patients with squamous cell carcinoma of the head and neck. Cancer 1991; 67: 2741-7.
20. Pekkola-Heino K. Radiation response of squamous cell carcinoma. In vitro studies with cell lines in a 96-well plate clonogenic assay. Academic dissertation. Turku, 1992.
21. Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Craig RW. Participation of p53 protein in the cellular response to DNA damage. Cancer Res 1991; 51: 6304-11.
22. Lane DP. p53, quardian of the genome. Nature 1992; 358: 15-6.
23. Caelles C, Helmberg A, Karin M. p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature 1994; 370: 220-3.
24. Smith ML, Chen I-T, Zhan Q, O'Connor PM, Fornace AJ. Involvement of the p53 tumor suppressor in repair of u.v.-type DNA damage. Oncogene 1995; 10: 1053-9.
25. Xia F, Wang X, Wang Y-H, et al. Altered p53 status correlates with dfferences in sensitivity to radiation-induced muta tion and apoptosis in two closely related human lympho blast lines. Cancer Res 1995; 55: 12-5.