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1
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10144246566
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Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene
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Whitcomb DC, Gorry MC, Preston RA, Furey W, Sossenheimer MU, Ulrich CD, Martin SP, Gates LK Jr, Amann ST, Toskes PP, et al.: Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet 1996, 14:141-145. A single point mutation involving the cationic trypsinogen gene is the cause of hereditary pancreatitis in some kindreds.
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Nat Genet
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Whitcomb, D.C.1
Gorry, M.C.2
Preston, R.A.3
Furey, W.4
Sossenheimer, M.U.5
Ulrich, C.D.6
Martin, S.P.7
Gates Jr., L.K.8
Amann, S.T.9
Toskes, P.P.10
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2
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0029788508
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Gabexate for the prevention of pancreatic damage related to endoscopic retrograde cholangiopancreatography
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Cavallini G, Tittobello A, Frulloni G, Masci E, Mariana A, DiFranceso V: Gabexate for the prevention of pancreatic damage related to endoscopic retrograde cholangiopancreatography. N Engl J Med 1996, 335:919-923. Treatment with gabexate, a trypsin inhibitor, prior to ERCP substantially reduced the frequency of ERCP-related acute pancreatitis.
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N Engl J Med
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Cavallini, G.1
Tittobello, A.2
Frulloni, G.3
Masci, E.4
Mariana, A.5
DiFranceso, V.6
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3
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0027415147
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Gabexate mesilate in human acute pancreatitis
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Buchler M, Malfertheiner P, Uhl W, Scholmerich J, Stockmann F, Adler G, Gaus W, Rolle K, Beger HG, and the German Pancreatitis Study Group: Gabexate mesilate in human acute pancreatitis. Gastroenterology 1993, 104:1165-1170.
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Gastroenterology
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Buchler, M.1
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Uhl, W.3
Scholmerich, J.4
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Adler, G.6
Gaus, W.7
Rolle, K.8
Beger, H.G.9
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4
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0023025329
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Beneficial effects of cholecystokinin-receptor blockage and inhibition of proteolytic enzyme activity in experimental acute hemorrhagic pancreatitis in mice: Evidence for cholecystokinin as a major factor in the development of acute pancreatitis
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Niederau C, Liddle RA, Ferrell LD, Grendell JH: Beneficial effects of cholecystokinin-receptor blockage and inhibition of proteolytic enzyme activity in experimental acute hemorrhagic pancreatitis in mice: evidence for cholecystokinin as a major factor in the development of acute pancreatitis. J Clin Invest 1986, 78:1056-1063.
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J Clin Invest
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Niederau, C.1
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Ferrell, L.D.3
Grendell, J.H.4
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5
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0029978482
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Increased monocyte cytokine production in association with systemic complications in acute pancreatitis
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McKay CJ, Gallagher G, Brooks B, Imrie CW, Baxter JN: Increased monocyte cytokine production in association with systemic complications in acute pancreatitis. Br J Surg 1996, 83:919-923. Systemic complications in patients with acute pancreatitis were associated with increased in vitro secretion by monocytes of the cytokines tumor necrosis factor-α, interleukin-6 and -8. This suggests a potential benefit for cytokine inhibitors in reducing the frequency of multiorgan system failure in acute pancreatitis.
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Br J Surg
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McKay, C.J.1
Gallagher, G.2
Brooks, B.3
Imrie, C.W.4
Baxter, J.N.5
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6
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0000293211
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Early treatment with lexipafant, a platelet-activating factor antagonist, reduces mortality in acute pancreatitis: A double-blind randomized, placebo-controlled study
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Kingsnorth AN: Early treatment with lexipafant, a platelet-activating factor antagonist, reduces mortality in acute pancreatitis: a double-blind randomized, placebo-controlled study [abstract]. Gastroenterology 1997, 112:A453.
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Gastroenterology
, vol.112
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Kingsnorth, A.N.1
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7
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0030317879
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What is the best biochemical test to diagnose acute pancreatitis? a prospective clinical study
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Sternby B, O'Brien JF, Zinsmeister AR, DiMagno EP: What is the best biochemical test to diagnose acute pancreatitis? A prospective clinical study. Mayo Clin Proc 1996, 71:1138-1144. Biochemical measurement in blood of a variety of pancreatic enzymes was evaluated in the diagnosis of acute pancreatitis, and measurement of pancreatic isoamylase was recommended as the best choice.
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(1996)
Mayo Clin Proc
, vol.71
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Sternby, B.1
O'Brien, J.F.2
Zinsmeister, A.R.3
DiMagno, E.P.4
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8
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0029738833
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Serum lipase and amylase ratio in acute alcoholic and nonalcoholic pancreatitis by using Dupont ACA discrete clinical analyzer
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Ansari E, Talenti DA, Scopelliti JA, Saadat JM, Zehr BD: Serum lipase and amylase ratio in acute alcoholic and nonalcoholic pancreatitis by using Dupont ACA discrete clinical analyzer. Dig Dis Sci 1996, 41:1823-1827. The lipase:amylase ratio did not help differentiate between alcoholic and nonalcoholic pancreatitis. An amylase level higher than 2000 IU/dL was very specific for nonalcoholic pancreatitis but not sensitive.
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(1996)
Dig Dis Sci
, vol.41
, pp. 1823-1827
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Ansari, E.1
Talenti, D.A.2
Scopelliti, J.A.3
Saadat, J.M.4
Zehr, B.D.5
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9
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0029841462
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Biochemical parameters in the early differentiation of the etiology of acute pancreatitis
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Stimac D, Rubinic M, Lenac T, Kovac D, Vcev A, Miletic D: Biochemical parameters in the early differentiation of the etiology of acute pancreatitis. Am J Gastroenterol 1996, 91:2355-2359. A multivariate analysis suggested that nonalcoholic and alcoholic pancreatitis can be differentiated using a combination of the lipase:amylase ratio, erythrocyte mean corpuscular volume, and serum alkaline phosphatase.
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(1996)
Am J Gastroenterol
, vol.91
, pp. 2355-2359
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Stimac, D.1
Rubinic, M.2
Lenac, T.3
Kovac, D.4
Vcev, A.5
Miletic, D.6
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10
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0029988803
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Urinary trypsinogen activation peptides (TAP) are not increased in mild ERCP-induced pancreatitis
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Banks PA, Carr-Locke D, Slivka A, Van Dam J, Lichtenstein DR, Hughes M: Urinary trypsinogen activation peptides (TAP) are not increased in mild ERCP-induced pancreatitis. Pancreas 1996, 12:294-297. Measurement of urinary trypsinogen activation peptide was not helpful in the early diagnosis of ERCP-related pancreatitis.
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(1996)
Pancreas
, vol.12
, pp. 294-297
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Banks, P.A.1
Carr-Locke, D.2
Slivka, A.3
Van Dam, J.4
Lichtenstein, D.R.5
Hughes, M.6
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11
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0029910904
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Influence of etiology on the course and outcome of acute pancreatitis
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Uhl W, Isenmann R, Curti G, Vogel R, Beger HG, Buchler MW: Influence of etiology on the course and outcome of acute pancreatitis. Pancreas 1996, 13:335-343. No statistically significant differences were observed in the rate of infected necrosis or mortality among alcohol-related acute pancreatitis, gallstone acute pancreatitis, and acute pancreatitis due to other causes. However, there was a trend toward higher mortality in gallstone pancreatitis.
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(1996)
Pancreas
, vol.13
, pp. 335-343
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Uhl, W.1
Isenmann, R.2
Curti, G.3
Vogel, R.4
Beger, H.G.5
Buchler, M.W.6
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12
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0030466219
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Pancreatitis associated protein as an early marker of acute pancreatitis
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Kemppainen E, Sand J, Puolakkanen P, Laine S, Hedstrom J, Sainio V, Haapianen R, Nordback F: Pancreatitis associated protein as an early marker of acute pancreatitis. Gut 1996, 39:675-678. Admission values for pancreatitis associated protein are no better than those for C-reactive protein in distinguishing severe from mild acute pancreatitis.
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(1996)
Gut
, vol.39
, pp. 675-678
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Kemppainen, E.1
Sand, J.2
Puolakkanen, P.3
Laine, S.4
Hedstrom, J.5
Sainio, V.6
Haapianen, R.7
Nordback, F.8
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13
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0029978483
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Early localization of necrosis by contrast-enhanced computed tomography can predict outcome in severe acute pancreatitis
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Kemppainen E, Sainio V, Haapianen R, Kivisaari L, Kivilaakso E, Puolakkainen P: Early localization of necrosis by contrast-enhanced computed tomography can predict outcome in severe acute pancreatitis. Br J Surg 1996, 83:924-929. In this report the presence on CT of necrosis in the head of the pancreas was a stronger predictor of complications than the extent of involvement of the gland as estimated by CT.
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(1996)
Br J Surg
, vol.83
, pp. 924-929
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Kemppainen, E.1
Sainio, V.2
Haapianen, R.3
Kivisaari, L.4
Kivilaakso, E.5
Puolakkainen, P.6
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14
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0028008556
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Intravenous contrast medium accentuates the severity of acute necrotizing pancreatitis in the rat
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Foitzik T, Bassi DG, Schmidt J, Lewandrowki BK, Fernandez-del Castillo C, Rattner DW, Warshaw AL: Intravenous contrast medium accentuates the severity of acute necrotizing pancreatitis in the rat Gastroenterology 1994, 106:207-214.
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(1994)
Gastroenterology
, vol.106
, pp. 207-214
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Foitzik, T.1
Bassi, D.G.2
Schmidt, J.3
Lewandrowki, B.K.4
Fernandez-del Castillo, C.5
Rattner, D.W.6
Warshaw, A.L.7
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15
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0030018216
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A retrospective analysis of the effect of contrast-enhanced CT on the outcome of acute pancreatitis
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McMenamin DA, Gates LK Jr: A retrospective analysis of the effect of contrast-enhanced CT on the outcome of acute pancreatitis. Am J Gastroenterol 1996, 91:1384-1387. Patients who had undergone early contrast-enhanced CT had longer hospitalizations than those who did not.
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(1996)
Am J Gastroenterol
, vol.91
, pp. 1384-1387
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McMenamin, D.A.1
Gates Jr., L.K.2
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16
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0029839697
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Acute renal failure as a complication of acute pancreatitis
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Ljutic D, Piplovic-Vukovic T, Raos V, Andrews P: Acute renal failure as a complication of acute pancreatitis. Ren Fail 1996, 18:629-633. In this series acute renal failure occurred in only 4.4% of patients with acute pancreatitis but was associated with a mortality of 58%.
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(1996)
Ren Fail
, vol.18
, pp. 629-633
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Ljutic, D.1
Piplovic-Vukovic, T.2
Raos, V.3
Andrews, P.4
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17
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0029839696
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Acute renal failure complicating severe acute pancreatitis
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Kes P, Vucicevic Z, Ratkovic-Gusic I, Fotivec A: Acute renal failure complicating severe acute pancreatitis. Ren Fail 1996, 18:621-628. Acute renal failure was observed in 14% of patients, usually as part of multiorgan system failure, and was associated with a mortality of 75%.
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(1996)
Ren Fail
, vol.18
, pp. 621-628
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Kes, P.1
Vucicevic, Z.2
Ratkovic-Gusic, I.3
Fotivec, A.4
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18
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0030000342
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Labeled granulocyte scanning for the diagnosis of infected necrosis in acute pancreatitis: What kind of labeling should be used?
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Heresbach D, Devillers A, Rabot A, Moisan A, Malledant Y, Bourget P, Bretagne JF, Gosselin M: Labeled granulocyte scanning for the diagnosis of infected necrosis in acute pancreatitis: what kind of labeling should be used? Pancreas 1996, 12:381-387. Scintigraphy using labeled granulocytes can aid in the identification of infected necrosis, but it does not appear preferable in most cases to CT-guided aspiration of suspected areas of infected necrosis.
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(1996)
Pancreas
, vol.12
, pp. 381-387
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Heresbach, D.1
Devillers, A.2
Rabot, A.3
Moisan, A.4
Malledant, Y.5
Bourget, P.6
Bretagne, J.F.7
Gosselin, M.8
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19
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0029789030
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Influence of severe underlying pathology and hypovolemic shock on the development of acute pancreatitis in children
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Benney T, Belli D, Bugmann P, Bechetti M, Morel P, Le Coultre C: Influence of severe underlying pathology and hypovolemic shock on the development of acute pancreatitis in children. J Pediatr Surg 1996, 34:1256-1266. Not surprisingly acute pancreatitis in children carries a higher mortality if it develops in the setting of hypovolemic shock or other comorbid conditions.
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(1996)
J Pediatr Surg
, vol.34
, pp. 1256-1266
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Benney, T.1
Belli, D.2
Bugmann, P.3
Bechetti, M.4
Morel, P.5
Le Coultre, C.6
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20
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1842291602
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Early ERCP and papillotomy compared with conservative treatment for acute biliary pancreatitis
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The German Study Group on Acute Biliary Pancreatitis
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Folsch UR, Nitsche R, Ludtke R, Hilgers RA, Creutzfeldt W: Early ERCP and papillotomy compared with conservative treatment for acute biliary pancreatitis. The German Study Group on Acute Biliary Pancreatitis. N Engl J Med 1997, 336:237-242. In a highly selected group of patients with gallstone pancreatitis but without evidence of cholangitis or biliary obstruction, early ERCP and sphincterotomy did not improve the outcome.
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(1997)
N Engl J Med
, vol.336
, pp. 237-242
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Folsch, U.R.1
Nitsche, R.2
Ludtke, R.3
Hilgers, R.A.4
Creutzfeldt, W.5
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21
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0023791776
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Controlled trial of urgent endoscopic retrograde cholangiopancreatography and endoscopic sphincterotomy versus conservative treatment for acute pancreatitis due to gallstones
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Neoptolemos JP, Carr-Locke DL, London NJ, Bailey IA, James D, Fossard DP: Controlled trial of urgent endoscopic retrograde cholangiopancreatography and endoscopic sphincterotomy versus conservative treatment for acute pancreatitis due to gallstones. Lancet 1988, ii:979-983.
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Lancet
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Neoptolemos, J.P.1
Carr-Locke, D.L.2
London, N.J.3
Bailey, I.A.4
James, D.5
Fossard, D.P.6
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22
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0001222181
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Final results of the prospective, randomized, controlled study for endoscopic sphincterotomy versus conventional management in acute biliary pancreatitis
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Nowak A, Nowakowska-Dulawa E, Marek TA, Rybicka J: Final results of the prospective, randomized, controlled study for endoscopic sphincterotomy versus conventional management in acute biliary pancreatitis [abstract]. Gastroenterology 1995, 108:A380.
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(1995)
Gastroenterology
, vol.108
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Nowak, A.1
Nowakowska-Dulawa, E.2
Marek, T.A.3
Rybicka, J.4
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23
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0029900166
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Surgical strategy and management of infected pancreatic necrosis
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Farkas G, Marton J, Mandi Y, Szederrenyi E: Surgical strategy and management of infected pancreatic necrosis. Br J Surg 1996, 83:930-933. Operative debridement with continuous lavage and drainage along with antimicrobial therapy produced outstanding results with a hospital mortality of only 7%.
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(1996)
Br J Surg
, vol.83
, pp. 930-933
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Farkas, G.1
Marton, J.2
Mandi, Y.3
Szederrenyi, E.4
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24
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0029835207
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Endoscopic therapy for organized pancreatic necrosis
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Baron TH, Thaggard WG, Morgan DE, Stanley RJ: Endoscopic therapy for organized pancreatic necrosis. Gastroenterology 1996, 111:755-764. Three patients with infected pancreatic necrosis were treated successfully using endoscopic therapy.
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(1996)
Gastroenterology
, vol.111
, pp. 755-764
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Baron, T.H.1
Thaggard, W.G.2
Morgan, D.E.3
Stanley, R.J.4
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25
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0029881496
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Infected pancreatic necrosis and peripancreatic fluid collections: Serendipitous response to antibiotic and medical therapy in three patients
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Dubner H, Steinberg WH, Hill M, Bassi C, Chardavoyne R, Bank S: Infected pancreatic necrosis and peripancreatic fluid collections: serendipitous response to antibiotic and medical therapy in three patients. Pancreas 1996, 12:298-302. Another three patients with infected necrosis survived following antibiotic therapy alone.
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(1996)
Pancreas
, vol.12
, pp. 298-302
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Dubner, H.1
Steinberg, W.H.2
Hill, M.3
Bassi, C.4
Chardavoyne, R.5
Bank, S.6
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26
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0030030619
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Nonsurgical treatment of acute necrotizing pancreatitis
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Uomo G, Visconti M, Manes G, Cause F, Laccetti M, Rabitti PG: Nonsurgical treatment of acute necrotizing pancreatitis. Pancreas 1996, 12:142-148. More evidence that patients with severe acute pancreatitis and sterile necrosis should generally be treated nonoperatively.
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(1996)
Pancreas
, vol.12
, pp. 142-148
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Uomo, G.1
Visconti, M.2
Manes, G.3
Cause, F.4
Laccetti, M.5
Rabitti, P.G.6
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27
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0030481727
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A critical review of antibiotic prophylaxis in severe acute pancreatitis
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Barie PS: A critical review of antibiotic prophylaxis in severe acute pancreatitis. Am J Surg 1996, 172(6A):38S-43S. A thorough, scholarly review of this still controversial topic.
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(1996)
Am J Surg
, vol.172
, Issue.6 A
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Barie, P.S.1
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28
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0030248706
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Pancreatic pseudocysts following acute pancreatitis
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Behrman SW, Melvin WS, Ellison CS: Pancreatic pseudocysts following acute pancreatitis. Am J Surg 1996, 172:228-231. This small, retrospective review suggests that pseudocysts of 10 cm or more in diameter developing after acute pancreatitis are associated with high rates of morbidity and mortality.
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(1996)
Am J Surg
, vol.172
, pp. 228-231
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Behrman, S.W.1
Melvin, W.S.2
Ellison, C.S.3
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29
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0029761112
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Should ERCP be routine after an episode of "idiopathic" pancreatitis? A cost-utility analysis
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Gregor JC, Ponich TP, Detsky AS: Should ERCP be routine after an episode of "idiopathic" pancreatitis? A cost-utility analysis. Gastrointest Endosc 1996, 44:118-123. Based on a mathematical model, the benefit and cost-effectiveness of ERCP would be substantial if a subgroup of these patients with a high likelihood of occult gallstone disease could be identified.
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(1996)
Gastrointest Endosc
, vol.44
, pp. 118-123
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Gregor, J.C.1
Ponich, T.P.2
Detsky, A.S.3
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