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Volumn 12, Issue 7, 2000, Pages 835-844

Cloning and functional characterization of a novel c-mpl variant expressed in human CD34 cells and platelets

Author keywords

c mpl; CD34 cells; Megakaryocyte; Platelet; Thrombopoietin

Indexed keywords

CD34 ANTIGEN; CYTOKINE; CYTOKINE RECEPTOR; IODINE 125; ISOPROTEIN; RECOMBINANT THROMBOPOIETIN; RNA; THROMBOPOIETIN;

EID: 0033926164     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1006/cyto.1999.0654     Document Type: Article
Times cited : (22)

References (41)
  • 1
    • 0031051965 scopus 로고    scopus 로고
    • Thrombopoietin: Understanding and manipulating platelet production
    • Kaushansky K (1997) Thrombopoietin: understanding and manipulating platelet production. Annu Rev Med 48:1-11.
    • (1997) Annu Rev Med , vol.48 , pp. 1-11
    • Kaushansky, K.1
  • 2
    • 0030845148 scopus 로고    scopus 로고
    • In vivo effects of Mpl ligand administration and emerging clinical applications for the Mpl ligands
    • Kuter DJ (1997) In vivo effects of Mpl ligand administration and emerging clinical applications for the Mpl ligands. Curr Opin Hematol 4:163-170.
    • (1997) Curr Opin Hematol , vol.4 , pp. 163-170
    • Kuter, D.J.1
  • 4
    • 0029030356 scopus 로고
    • The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit
    • Kuter DJ, Rosenberg RD (1995) The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit. Blood 85:2720-2730.
    • (1995) Blood , vol.85 , pp. 2720-2730
    • Kuter, D.J.1    Rosenberg, R.D.2
  • 5
    • 0032125714 scopus 로고    scopus 로고
    • Thrombopoietin and the hematopoietic stem cell
    • Kaushansky K (1998) Thrombopoietin and the hematopoietic stem cell. Blood 92:1-3.
    • (1998) Blood , vol.92 , pp. 1-3
    • Kaushansky, K.1
  • 6
    • 0026684707 scopus 로고
    • Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: Identification of a member of the hematopoietic growth factor receptor superfamily
    • Vigon I, Mornon JP, Cocault L, Mitjavila MT, Tambourin P, Gisselbrecht S, Souyri M (1992) Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily. Proc Natl Acad Sci USA 89:5640-5644.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 5640-5644
    • Vigon, I.1    Mornon, J.P.2    Cocault, L.3    Mitjavila, M.T.4    Tambourin, P.5    Gisselbrecht, S.6    Souyri, M.7
  • 7
    • 0029171091 scopus 로고
    • Structure and function of the cytokine receptor superfamily
    • Drachman JG, Kaushansky K (1995) Structure and function of the cytokine receptor superfamily. Curr Opin Hematol 2:22-28.
    • (1995) Curr Opin Hematol , vol.2 , pp. 22-28
    • Drachman, J.G.1    Kaushansky, K.2
  • 9
    • 0003350616 scopus 로고    scopus 로고
    • Analysis of the thrombopoietin receptor (MPL) on platelets from normal and essential thrombocythemic (ET) patients
    • Li J, Xia Y, Kuter DJ (1996) Analysis of the thrombopoietin receptor (MPL) on platelets from normal and essential thrombocythemic (ET) patients. Blood 88:S2168.
    • (1996) Blood , vol.88
    • Li, J.1    Xia, Y.2    Kuter, D.J.3
  • 12
    • 0028832719 scopus 로고
    • Point mutations within a dimer interface homology domain of c-Mpl induce constitutive receptor activity and tumorigenicity
    • Alexander WS, Metcalf D, Dunn AR (1995) Point mutations within a dimer interface homology domain of c-Mpl induce constitutive receptor activity and tumorigenicity. EMBO J 14:5569-5578.
    • (1995) EMBO J , vol.14 , pp. 5569-5578
    • Alexander, W.S.1    Metcalf, D.2    Dunn, A.R.3
  • 13
    • 0028910991 scopus 로고
    • The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl
    • Drachman JG, Griffin JD, Kaushansky K (1995) The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl. J Biol Chem 270:4979-4982.
    • (1995) J Biol Chem , vol.270 , pp. 4979-4982
    • Drachman, J.G.1    Griffin, J.D.2    Kaushansky, K.3
  • 14
    • 0028827190 scopus 로고
    • Thrombopoietin, c-Mpl ligand, induces tyrosine phosphorylation of Tyk2, JAK2, and STAT3, and enhances agonists-induced aggregation in platelets in vitro
    • Ezumi Y, Takayama H, Okuma M (1995) Thrombopoietin, c-Mpl ligand, induces tyrosine phosphorylation of Tyk2, JAK2, and STAT3, and enhances agonists-induced aggregation in platelets in vitro. FEBS Lett 374:48-52.
    • (1995) FEBS Lett , vol.374 , pp. 48-52
    • Ezumi, Y.1    Takayama, H.2    Okuma, M.3
  • 16
    • 0030945262 scopus 로고    scopus 로고
    • Thrombopoietin and thrombin induce tyrosine phosphorylation of Vav in human blood platelets
    • Miyakawa Y, Oda A, Druker BJ, Ozaki K, Handa M, Ohashi H, Ikeda Y (1997) Thrombopoietin and thrombin induce tyrosine phosphorylation of Vav in human blood platelets. Blood 89:2789-2798.
    • (1997) Blood , vol.89 , pp. 2789-2798
    • Miyakawa, Y.1    Oda, A.2    Druker, B.J.3    Ozaki, K.4    Handa, M.5    Ohashi, H.6    Ikeda, Y.7
  • 17
    • 0029052479 scopus 로고
    • Recombinant thrombopoietin induces rapid protein tyrosine phosphorylation of Janus kinase 2 and Shc in human blood platelets
    • Miyakawa Y, Oda A, Druker BJ, Kato T, Miyazaki H, Handa M, Ikeda Y (1995) Recombinant thrombopoietin induces rapid protein tyrosine phosphorylation of Janus kinase 2 and Shc in human blood platelets. Blood 86:23-27.
    • (1995) Blood , vol.86 , pp. 23-27
    • Miyakawa, Y.1    Oda, A.2    Druker, B.J.3    Kato, T.4    Miyazaki, H.5    Handa, M.6    Ikeda, Y.7
  • 18
    • 0028864865 scopus 로고
    • Megakaryocyte growth and development factor and interleukin-3 induce patterns of protein-tyrosine phosphorylation that correlate with dominant differentiation over proliferation of mpl-transfected 32D cells
    • Mu SX, Xia M, Elliott G, Bogenberger J, Swift S, Bennett L, Lappinga DL, Hecht R, Lee R, Saris CJ (1995) Megakaryocyte growth and development factor and interleukin-3 induce patterns of protein-tyrosine phosphorylation that correlate with dominant differentiation over proliferation of mpl-transfected 32D cells. Blood 86:4532-4543.
    • (1995) Blood , vol.86 , pp. 4532-4543
    • Mu, S.X.1    Xia, M.2    Elliott, G.3    Bogenberger, J.4    Swift, S.5    Bennett, L.6    Lappinga, D.L.7    Hecht, R.8    Lee, R.9    Saris, C.J.10
  • 19
    • 0029666503 scopus 로고    scopus 로고
    • P120c-cbl is present in human blood platelets and is differentially involved in signaling by thrombopoietin and thrombin
    • Oda A, Ozaki K, Druker BJ, Miyakawa Y, Miyazaki H, Handa M, Morita H, Ohashi H, Ikeda Y (1996) p120c-cbl is present in human blood platelets and is differentially involved in signaling by thrombopoietin and thrombin. Blood 88:1330-1338.
    • (1996) Blood , vol.88 , pp. 1330-1338
    • Oda, A.1    Ozaki, K.2    Druker, B.J.3    Miyakawa, Y.4    Miyazaki, H.5    Handa, M.6    Morita, H.7    Ohashi, H.8    Ikeda, Y.9
  • 20
    • 0032496031 scopus 로고    scopus 로고
    • Thrombopoietin induces tyrosine phosphorylation of a common beta subunit of GM-CSF receptor and its association with Stat5 in TF-1/TPO cells
    • Ooi J, Tojo A, Asano S, Sato Y, Oka Y (1998) Thrombopoietin induces tyrosine phosphorylation of a common beta subunit of GM-CSF receptor and its association with Stat5 in TF-1/TPO cells. Biochem Biophys Res Commun 246:132-136.
    • (1998) Biochem Biophys Res Commun , vol.246 , pp. 132-136
    • Ooi, J.1    Tojo, A.2    Asano, S.3    Sato, Y.4    Oka, Y.5
  • 21
    • 0030887288 scopus 로고    scopus 로고
    • Thrombopoietin induces activation of the phosphatidylinositol-3′ kinase pathway and formation of a complex containing p85PI3K and the protooncoprotein p120CBL
    • Sattler M, Salgia R, Durstin MA, Prasad KV, Griffin JD (1997) Thrombopoietin induces activation of the phosphatidylinositol-3′ kinase pathway and formation of a complex containing p85PI3K and the protooncoprotein p120CBL. J Cell Physiol 171:28-33.
    • (1997) J Cell Physiol , vol.171 , pp. 28-33
    • Sattler, M.1    Salgia, R.2    Durstin, M.A.3    Prasad, K.V.4    Griffin, J.D.5
  • 22
    • 0028803575 scopus 로고
    • TPO/c-mpl ligand induces tyrosine phosphorylation of multiple cellular proteins including proto-oncogene products, Vav and c-Cbl, and Ras signaling molecules
    • Sasaki K, Odai H, Hanazono Y, Ueno H, Ogawa S, Langdon WY, Tanaka T, Miyagawa K, Mitani K, Yazaki Y et al. (1995) TPO/c-mpl ligand induces tyrosine phosphorylation of multiple cellular proteins including proto-oncogene products, Vav and c-Cbl, and Ras signaling molecules. Biochem Biophys Res Commun 216:338-347.
    • (1995) Biochem Biophys Res Commun , vol.216 , pp. 338-347
    • Sasaki, K.1    Odai, H.2    Hanazono, Y.3    Ueno, H.4    Ogawa, S.5    Langdon, W.Y.6    Tanaka, T.7    Miyagawa, K.8    Mitani, K.9    Yazaki, Y.10
  • 23
    • 0030900247 scopus 로고    scopus 로고
    • Dissecting the thrombopoietin receptor: Functional elements of the Mpl cytoplasmic domain
    • Drachman JG, Kaushansky K (1997) Dissecting the thrombopoietin receptor: functional elements of the Mpl cytoplasmic domain. Proc Natl Acad Sci USA 94:2350-2355.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 2350-2355
    • Drachman, J.G.1    Kaushansky, K.2
  • 24
    • 0032842829 scopus 로고    scopus 로고
    • Interaction of thrombopoietin with the platelet c-mpl receptor in plasma: Binding, internalization, stability, and pharmacokinetics
    • Li J, Xia Y, Kuter DJ (1999) Interaction of thrombopoietin with the platelet c-mpl receptor in plasma: binding, internalization, stability, and pharmacokinetics. Br J Haematol 106:345-356.
    • (1999) Br J Haematol , vol.106 , pp. 345-356
    • Li, J.1    Xia, Y.2    Kuter, D.J.3
  • 26
    • 0025674093 scopus 로고
    • A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors
    • Souyri M, Vigon I, Penciolelli JF, Heard JM, Tambourin P, Wendling F (1990) A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors. Cell 63:1137-1147.
    • (1990) Cell , vol.63 , pp. 1137-1147
    • Souyri, M.1    Vigon, I.2    Penciolelli, J.F.3    Heard, J.M.4    Tambourin, P.5    Wendling, F.6
  • 27
    • 0025869672 scopus 로고
    • The oncogene V-MPL, a putative truncated cytokine receptor which immortalizes hematopoietic progenitors
    • Wendling F, Tambourin P (1991) The oncogene V-MPL, a putative truncated cytokine receptor which immortalizes hematopoietic progenitors. Nouv Rev Fr Hematol 33:145-146.
    • (1991) Nouv Rev fr Hematol , vol.33 , pp. 145-146
    • Wendling, F.1    Tambourin, P.2
  • 28
    • 0029912139 scopus 로고    scopus 로고
    • Effects of recombinant human megakaryocyte growth and development factor on platelet activation
    • Montrucchio G, Brizzi MF, Calosso G, Marengo S, Pegoraro L, Camussi G (1996) Effects of recombinant human megakaryocyte growth and development factor on platelet activation. Blood 87:2762-2768.
    • (1996) Blood , vol.87 , pp. 2762-2768
    • Montrucchio, G.1    Brizzi, M.F.2    Calosso, G.3    Marengo, S.4    Pegoraro, L.5    Camussi, G.6
  • 30
    • 0029956149 scopus 로고    scopus 로고
    • A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin (mpl ligand): Reversal of disease by bone marrow transplantation
    • Yan XQ, Lacey D, Hill D, Chen Y, Fletcher F, Hawley RG, McNiece IK (1996) A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin (mpl ligand): reversal of disease by bone marrow transplantation. Blood 88: 402-409.
    • (1996) Blood , vol.88 , pp. 402-409
    • Yan, X.Q.1    Lacey, D.2    Hill, D.3    Chen, Y.4    Fletcher, F.5    Hawley, R.G.6    McNiece, I.K.7
  • 31
    • 0031916263 scopus 로고    scopus 로고
    • Major effects of TPO delivered by a single injection of a recombinant adenovirus on prevention of septicemia and anemia associated with myelosuppression in mice: Risk of sustained expression inducing myelofibrosis due to immunosuppression
    • Abina MA, Tulliez M, Lacout C, Debili N, Villeval JL, Pflumio F, Wendling F, Vainchenker W, Haddada H (1998) Major effects of TPO delivered by a single injection of a recombinant adenovirus on prevention of septicemia and anemia associated with myelosuppression in mice: risk of sustained expression inducing myelofibrosis due to immunosuppression. Gene Ther 5:497-506.
    • (1998) Gene Ther , vol.5 , pp. 497-506
    • Abina, M.A.1    Tulliez, M.2    Lacout, C.3    Debili, N.4    Villeval, J.L.5    Pflumio, F.6    Wendling, F.7    Vainchenker, W.8    Haddada, H.9
  • 33
    • 0029817962 scopus 로고    scopus 로고
    • Ectopic expression of murine TPO receptor (c-mpl) in mice is pathogenic and induces erythroblastic proliferation
    • Cocault L, Bouscary D, Le Bousse Kerdiles C, Clay D, Picard F, Gisselbrecht S, Souyri M (1996) Ectopic expression of murine TPO receptor (c-mpl) in mice is pathogenic and induces erythroblastic proliferation. Blood 88:1656-1665.
    • (1996) Blood , vol.88 , pp. 1656-1665
    • Cocault, L.1    Bouscary, D.2    Le Bousse Kerdiles, C.3    Clay, D.4    Picard, F.5    Gisselbrecht, S.6    Souyri, M.7
  • 34
    • 0029037953 scopus 로고
    • The Mpl-ligand or thrombopoietin or megakaryocyte growth and differentiative factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors
    • Debili N, Wendling F, Katz A, Guichard J, Breton-Gorius J, Hunt P, Vainchenker W (1995) The Mpl-ligand or thrombopoietin or megakaryocyte growth and differentiative factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors. Blood 86:2516-2525.
    • (1995) Blood , vol.86 , pp. 2516-2525
    • Debili, N.1    Wendling, F.2    Katz, A.3    Guichard, J.4    Breton-Gorius, J.5    Hunt, P.6    Vainchenker, W.7
  • 36
    • 0033168819 scopus 로고    scopus 로고
    • Deletion of the extracellular membrane-distal cytokine receptor homology module of Mpl results in constitutive cell growth and loss of thrombopoietin binding
    • Sabath DF, Kaushansky K, Broudy VC (1999) Deletion of the extracellular membrane-distal cytokine receptor homology module of Mpl results in constitutive cell growth and loss of thrombopoietin binding. Blood 94:365-367.
    • (1999) Blood , vol.94 , pp. 365-367
    • Sabath, D.F.1    Kaushansky, K.2    Broudy, V.C.3
  • 40
    • 0032191612 scopus 로고    scopus 로고
    • Expression and regulation of the thrombopoietin receptor variants MPLP and MPLK in PBMC
    • Rollinger-Holzinger I, Griesser U, Pollak V, Zwierzina H (1998) Expression and regulation of the thrombopoietin receptor variants MPLP and MPLK in PBMC. Cytokine 10:795-802.
    • (1998) Cytokine , vol.10 , pp. 795-802
    • Rollinger-Holzinger, I.1    Griesser, U.2    Pollak, V.3    Zwierzina, H.4
  • 41
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival
    • Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival. J Immunol Methods 65:55-63.
    • (1983) J Immunol Methods , vol.65 , pp. 55-63
    • Mosmann, T.1


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