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Volumn 48, Issue , 1997, Pages 1-11

Thrombopoietin: Understanding and manipulating platelet production

Author keywords

Hematopoiesis; Megakaryocytes; Mp1 ligand; Platelet production; Thrombopoiesis

Indexed keywords

CYTOKINE; HORMONE; RECEPTOR; THROMBOPOIETIN;

EID: 0031051965     PISSN: 00664219     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.med.48.1.1     Document Type: Review
Times cited : (39)

References (82)
  • 1
    • 0028302409 scopus 로고
    • Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand
    • de Sauvage FJ, Hass PE, Spencer SD, et al. 1994. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 369:533-38
    • (1994) Nature , vol.369 , pp. 533-538
    • De Sauvage, F.J.1    Hass, P.E.2    Spencer, S.D.3
  • 2
    • 0028199208 scopus 로고
    • Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo
    • Lok S, Kaushansky K, Holly R, et al. 1994. Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 369:565-68
    • (1994) Nature , vol.369 , pp. 565-568
    • Lok, S.1    Kaushansky, K.2    Holly, R.3
  • 3
    • 0028343099 scopus 로고
    • Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl
    • Bartley TD, Bogenberger J, Hunt P, et al. 1994. Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell 77:1117-24
    • (1994) Cell , vol.77 , pp. 1117-1124
    • Bartley, T.D.1    Bogenberger, J.2    Hunt, P.3
  • 4
    • 0027992924 scopus 로고
    • Molecular cloning and chromosomal localization of the human thrombopoietin gene
    • Sohma Y, Akahori H, Seki N, et al. 1994. Molecular cloning and chromosomal localization of the human thrombopoietin gene. FEBS Lett. 353:57-61
    • (1994) FEBS Lett. , vol.353 , pp. 57-61
    • Sohma, Y.1    Akahori, H.2    Seki, N.3
  • 5
    • 0028117771 scopus 로고
    • The purification of megapoietin: A physiological regulator of megakaryocyte growth and platelet production
    • Kuter DJ, Beeler DL, Rosenberg RD. 1994. The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production. Proc. Natl. Acad. Sci. USA 91:11104-8
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 11104-11108
    • Kuter, D.J.1    Beeler, D.L.2    Rosenberg, R.D.3
  • 6
    • 0023891872 scopus 로고
    • Thrombopoietin: Its biology, purification, and characterization
    • McDonald TP. 1988. Thrombopoietin: its biology, purification, and characterization. Exp. Hematol. 16:201-5
    • (1988) Exp. Hematol. , vol.16 , pp. 201-205
    • McDonald, T.P.1
  • 7
    • 0024585636 scopus 로고
    • Regulators of thrombopoiesis: Their biochemistry and physiology
    • Hill RJ, Levin J. 1989. Regulators of thrombopoiesis: their biochemistry and physiology. Blood Cells 15:141-66
    • (1989) Blood Cells , vol.15 , pp. 141-166
    • Hill, R.J.1    Levin, J.2
  • 8
    • 0013826135 scopus 로고
    • The cloning of normal mast cells in tissue culture
    • Pluznik DH, Sachs L. 1965. The cloning of normal mast cells in tissue culture. J. Cell. Physiol. 66:319-24
    • (1965) J. Cell. Physiol. , vol.66 , pp. 319-324
    • Pluznik, D.H.1    Sachs, L.2
  • 10
    • 0027136259 scopus 로고
    • Hematopoietic regulators: Redundancy or subtlety?
    • Metcalf D. 1993. Hematopoietic regulators: redundancy or subtlety? Blood 82: 3515-23
    • (1993) Blood , vol.82 , pp. 3515-3523
    • Metcalf, D.1
  • 11
    • 0027325195 scopus 로고
    • Differentiation and proliferation of hematopoietic stem cells
    • Ogawa M. 1993. Differentiation and proliferation of hematopoietic stem cells. Blood 81:2844-53
    • (1993) Blood , vol.81 , pp. 2844-2853
    • Ogawa, M.1
  • 12
    • 0019132455 scopus 로고
    • Properties of human pluripotent hemopoietic progenitors
    • Messner HA, Fauser AA, Lepine J, et al. 1980. Properties of human pluripotent hemopoietic progenitors. Blood Cells 6: 595-607
    • (1980) Blood Cells , vol.6 , pp. 595-607
    • Messner, H.A.1    Fauser, A.A.2    Lepine, J.3
  • 13
    • 0019496225 scopus 로고
    • Studies of human pluripotential hemopoietic stem cells (CFU-GEMM) in vitro
    • Ash RC, Detrick DA, Zanjani ED. 1981. Studies of human pluripotential hemopoietic stem cells (CFU-GEMM) in vitro. Blood 58:309-16
    • (1981) Blood , vol.58 , pp. 309-316
    • Ash, R.C.1    Detrick, D.A.2    Zanjani, E.D.3
  • 14
    • 0025888369 scopus 로고
    • Human burst forming units-erythroid need direct interaction with stem cell factor for further development
    • Dai CH, Krantz SB, Zsebo KM. 1991. Human burst forming units-erythroid need direct interaction with stem cell factor for further development. Blood 78: 2493-97
    • (1991) Blood , vol.78 , pp. 2493-2497
    • Dai, C.H.1    Krantz, S.B.2    Zsebo, K.M.3
  • 15
    • 0028276818 scopus 로고
    • Distinct roles of erythropoietin, insulin like growth factor I, and stem cell factor in the development of erythroid progenitor cells
    • Muta K, Krantz SB, Bondurant MC, et al. 1994. Distinct roles of erythropoietin, insulin like growth factor I, and stem cell factor in the development of erythroid progenitor cells. J. Clin. Invest. 94:34-43
    • (1994) J. Clin. Invest. , vol.94 , pp. 34-43
    • Muta, K.1    Krantz, S.B.2    Bondurant, M.C.3
  • 16
    • 0018625422 scopus 로고
    • Hereditary anemias of the mouse: A review for geneticists
    • Russell ES. 1979. Hereditary anemias of the mouse: a review for geneticists. Adv. Genet. 20:357-459
    • (1979) Adv. Genet. , vol.20 , pp. 357-459
    • Russell, E.S.1
  • 17
    • 0025093247 scopus 로고
    • Steel locus defines new multipotent growth factor
    • Witte ON. 1990. Steel locus defines new multipotent growth factor. Cell 63:5-6
    • (1990) Cell , vol.63 , pp. 5-6
    • Witte, O.N.1
  • 18
    • 0025979427 scopus 로고
    • Transmembrane form of the kit ligand growth factor is determined by alternate splicing and is missing in the Sld mutant
    • Flanagan JG, Chan DC, Leder P. 1991. Transmembrane form of the kit ligand growth factor is determined by alternate splicing and is missing in the Sld mutant. Cell 64:1025-35
    • (1991) Cell , vol.64 , pp. 1025-1035
    • Flanagan, J.G.1    Chan, D.C.2    Leder, P.3
  • 19
    • 0024246820 scopus 로고
    • Effects of recombinant erythropoietin on the concentration and cycling status of human marrow hematopoietic progenitor cells in vivo
    • Dessypris EN, Graber SE, Krantz SB, et al. 1988. Effects of recombinant erythropoietin on the concentration and cycling status of human marrow hematopoietic progenitor cells in vivo. Blood 72:2060-62
    • (1988) Blood , vol.72 , pp. 2060-2062
    • Dessypris, E.N.1    Graber, S.E.2    Krantz, S.B.3
  • 20
    • 0023204443 scopus 로고
    • Synergistic myelopoietic actions in vivo after administration to mice of combinations of purified natural murine colony-stimulating factor 1, recombinant murine interleukin 3 and recombinant murine granulocyte/macrophage colony-stimulating factor
    • Broxmeyer HE, Williams DE, Hangoc G, et al. 1987. Synergistic myelopoietic actions in vivo after administration to mice of combinations of purified natural murine colony-stimulating factor 1, recombinant murine interleukin 3 and recombinant murine granulocyte/macrophage colony-stimulating factor. Proc. Natl. Acad. Sci. USA 84:3871-75
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 3871-3875
    • Broxmeyer, H.E.1    Williams, D.E.2    Hangoc, G.3
  • 21
    • 0024553883 scopus 로고
    • Effects of human interleukin-3 on granulocytic colony-forming cells in human bone marrow
    • Bot FJ, van Ejik L, Schipper P, et al. 1989. Effects of human interleukin-3 on granulocytic colony-forming cells in human bone marrow. Blood 73:1157-60
    • (1989) Blood , vol.73 , pp. 1157-1160
    • Bot, F.J.1    Van Ejik, L.2    Schipper, P.3
  • 22
    • 0028326056 scopus 로고
    • Effects of interleukin-3 and c-kit ligand on the survival of various classes of human hematopoietic progenitor cells
    • Brandt JE, Bhalla K, Hoffman R. 1994. Effects of interleukin-3 and c-kit ligand on the survival of various classes of human hematopoietic progenitor cells. Blood 83: 1507-14
    • (1994) Blood , vol.83 , pp. 1507-1514
    • Brandt, J.E.1    Bhalla, K.2    Hoffman, R.3
  • 23
    • 0024405767 scopus 로고
    • Action of interleukin-3, G-CSF, and GM-CSF on highly enriched human hematopoietic progenitor cells: Synergistic interaction of GM-CSF plus G-CSF
    • McNiece I, Andrews R, Stewart M, et al. 1989. Action of interleukin-3, G-CSF, and GM-CSF on highly enriched human hematopoietic progenitor cells: synergistic interaction of GM-CSF plus G-CSF. Blood 74:110-14
    • (1989) Blood , vol.74 , pp. 110-114
    • McNiece, I.1    Andrews, R.2    Stewart, M.3
  • 24
    • 0027399145 scopus 로고
    • Cooperative effects of interleukin-3 (IL-3), IL-5, and granulocyte-macrophage colony-stimulating factor: A new myeloid cell line inducible to eosinophils
    • Paul CC, Tolbert M, Mahrer S, et al. 1993. Cooperative effects of interleukin-3 (IL-3), IL-5, and granulocyte-macrophage colony-stimulating factor: a new myeloid cell line inducible to eosinophils. Blood 81:1193-99
    • (1993) Blood , vol.81 , pp. 1193-1199
    • Paul, C.C.1    Tolbert, M.2    Mahrer, S.3
  • 25
    • 0019971440 scopus 로고
    • Kinetic analysis of megakaryocyte numbers and ploidy levels in developing colonies from mouse bone marrow cells
    • Williams N, Jackson H. 1982. Kinetic analysis of megakaryocyte numbers and ploidy levels in developing colonies from mouse bone marrow cells. Cell Tissue Kinet. 15:483-94
    • (1982) Cell Tissue Kinet. , vol.15 , pp. 483-494
    • Williams, N.1    Jackson, H.2
  • 26
    • 0021965733 scopus 로고
    • Phorbol diesters stimulate the development of an early murine progenitor cell: The burst-forming unit-megakaryocyte
    • Long MW, Gragowski LL, Heffner CH, et al. 1985. Phorbol diesters stimulate the development of an early murine progenitor cell: the burst-forming unit-megakaryocyte. J. Clin. Invest. 76:431-38
    • (1985) J. Clin. Invest. , vol.76 , pp. 431-438
    • Long, M.W.1    Gragowski, L.L.2    Heffner, C.H.3
  • 27
    • 0025102658 scopus 로고
    • Cytokine regulation of the human burst-forming unit-megakaryocyte
    • Briddell RA, Hoffman R. 1990. Cytokine regulation of the human burst-forming unit-megakaryocyte. Blood 76:516-22
    • (1990) Blood , vol.76 , pp. 516-522
    • Briddell, R.A.1    Hoffman, R.2
  • 28
    • 0020076263 scopus 로고
    • Two-factor requirement for murine megakaryocyte colony formation
    • Williams N, Eger RR, Jackson HM, et al. 1982. Two-factor requirement for murine megakaryocyte colony formation. J. Cell. Physiol. 110:101-4
    • (1982) J. Cell. Physiol. , vol.110 , pp. 101-104
    • Williams, N.1    Eger, R.R.2    Jackson, H.M.3
  • 29
    • 0024543050 scopus 로고
    • Multiple levels of regulation of megakaryocytopoiesis
    • Williams N, Jackson H, Walker F, et al. 1989. Multiple levels of regulation of megakaryocytopoiesis. Blood Cells 15: 123-33
    • (1989) Blood Cells , vol.15 , pp. 123-133
    • Williams, N.1    Jackson, H.2    Walker, F.3
  • 30
    • 0024270384 scopus 로고
    • Analysis of murine megakaryocyte colony size and ploidy: Effects of interleukin-3
    • Segal GM, Stueve T, Adamson JW. 1988. Analysis of murine megakaryocyte colony size and ploidy: effects of interleukin-3. J. Cell. Physiol. 137:537-44
    • (1988) J. Cell. Physiol. , vol.137 , pp. 537-544
    • Segal, G.M.1    Stueve, T.2    Adamson, J.W.3
  • 31
    • 0027241138 scopus 로고
    • Effects of the recombinant hematopoietic growth factors interleukin-3, interleukin-6, stem cell factor, and leukemia inhibitory factor on the megakaryocytic differentiation of CD34+ cells
    • Debili N, Massé J-M, Katz A, et al. 1993. Effects of the recombinant hematopoietic growth factors interleukin-3, interleukin-6, stem cell factor, and leukemia inhibitory factor on the megakaryocytic differentiation of CD34+ cells. Blood 82:84-95
    • (1993) Blood , vol.82 , pp. 84-95
    • Debili, N.1    Massé, J.-M.2    Katz, A.3
  • 32
    • 0026513085 scopus 로고
    • Effects of the stem cell factor, c-kit ligand, on human megakaryocytic cells
    • Avraham H, Vannier E, Cowley S, et al. 1992. Effects of the stem cell factor, c-kit ligand, on human megakaryocytic cells. Blood 79:365-71
    • (1992) Blood , vol.79 , pp. 365-371
    • Avraham, H.1    Vannier, E.2    Cowley, S.3
  • 33
    • 0025720196 scopus 로고
    • Effect of c-kit ligand on in vitro human megakaryocytopoiesis
    • Briddell RA, Bruno E, Cooper RJ, et al. 1991. Effect of c-kit ligand on in vitro human megakaryocytopoiesis. Blood 78: 2854-59
    • (1991) Blood , vol.78 , pp. 2854-2859
    • Briddell, R.A.1    Bruno, E.2    Cooper, R.J.3
  • 34
    • 0022495791 scopus 로고
    • Genomic cloning, characterization and multilineage growth-promoting activity of human granulocyte-macrophage colony-stimulating factor
    • Kaushansky K, O'Hara RJ, Berkner K, et al. 1986. Genomic cloning, characterization and multilineage growth-promoting activity of human granulocyte-macrophage colony-stimulating factor. Proc. Natl. Acad. Sci. USA 83:3101-5
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 3101-3105
    • Kaushansky, K.1    O'Hara, R.J.2    Berkner, K.3
  • 35
    • 0000009286 scopus 로고
    • Demonstration and some properties of human thrombopoietin in thrombocythemic sera
    • Kelemen E, Cserhati I, Tanos B. 1958. Demonstration and some properties of human thrombopoietin in thrombocythemic sera. Acta Haematol. 20:350-55
    • (1958) Acta Haematol. , vol.20 , pp. 350-355
    • Kelemen, E.1    Cserhati, I.2    Tanos, B.3
  • 36
    • 0025964231 scopus 로고
    • Multifactor stimulation of megakaryocytopoiesis: Effects of interleukin-6
    • Quesenberry PJ, McGrath HE, Williams ME, et al. 1991. Multifactor stimulation of megakaryocytopoiesis: effects of interleukin-6. Exp. Hematol. 19:35-41
    • (1991) Exp. Hematol. , vol.19 , pp. 35-41
    • Quesenberry, P.J.1    McGrath, H.E.2    Williams, M.E.3
  • 37
    • 0025104076 scopus 로고
    • Interleukin 6 is a differentiation factor for human megakaryocytes in vitro
    • Kimura H, Ishibashi T, Uchida T, et al. 1990. Interleukin 6 is a differentiation factor for human megakaryocytes in vitro. Eur. J. Immunol. 20:1927-31
    • (1990) Eur. J. Immunol. , vol.20 , pp. 1927-1931
    • Kimura, H.1    Ishibashi, T.2    Uchida, T.3
  • 38
    • 11944260623 scopus 로고
    • Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine
    • Paul SR, Bennett F, Calvetti JA, et al. 1990. Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine. Proc. Natl. Acad. Sci. USA 87:7512-16
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 7512-7516
    • Paul, S.R.1    Bennett, F.2    Calvetti, J.A.3
  • 39
    • 0026630530 scopus 로고
    • Synergistic effects of interleukin 3 and interleukin 11 on murine megakaryopoiesis in serum-free culture
    • Yonemura Y, Kawakita M, Masuda T, et al. 1992. Synergistic effects of interleukin 3 and interleukin 11 on murine megakaryopoiesis in serum-free culture. Exp. Hematol. 20:1011-16
    • (1992) Exp. Hematol. , vol.20 , pp. 1011-1016
    • Yonemura, Y.1    Kawakita, M.2    Masuda, T.3
  • 40
    • 0026640964 scopus 로고
    • Leukemia inhibitory factor and interleukin-11 promote maturation of murine and human megakaryocytes in vitro
    • Burstein SA, Mei R-L, Henthorn J, et al. 1992. Leukemia inhibitory factor and interleukin-11 promote maturation of murine and human megakaryocytes in vitro. J. Cell. Physiol. 153:305-12
    • (1992) J. Cell. Physiol. , vol.153 , pp. 305-312
    • Burstein, S.A.1    Mei, R.-L.2    Henthorn, J.3
  • 41
    • 0025783077 scopus 로고
    • Is thrombopoietin interleukin 6?
    • Williams N. 1991. Is thrombopoietin interleukin 6? Exp. Hematol. 19:714-18
    • (1991) Exp. Hematol. , vol.19 , pp. 714-718
    • Williams, N.1
  • 42
    • 0026627869 scopus 로고
    • Evidence that interleukin-6 does not play a role in the stimulation of platelet production after induction of acute thrombocytopenia
    • Hill RJ, Warren MK, Levin J. et al. 1992. Evidence that interleukin-6 does not play a role in the stimulation of platelet production after induction of acute thrombocytopenia. Blood 80:346-51
    • (1992) Blood , vol.80 , pp. 346-351
    • Hill, R.J.1    Warren, M.K.2    Levin, J.3
  • 43
    • 0026604636 scopus 로고
    • Is interleukin 6 the physiological regulator of thrombopoiesis?
    • Straneva JE, van Besien KW, Derigs G, et al. 1992. Is interleukin 6 the physiological regulator of thrombopoiesis? Exp. Hematol. 20:47-50
    • (1992) Exp. Hematol. , vol.20 , pp. 47-50
    • Straneva, J.E.1    Van Besien, K.W.2    Derigs, G.3
  • 44
    • 0027404230 scopus 로고
    • Synergism between serum factor(s) and erythropoietin in inducing murine megakaryocyte colony formation: The synergistic factor in serum is distinct from interleukin-11 and stem cell factor (c-kit ligand)
    • Tsukada J, Misago M, Ogawa R, et al. 1993. Synergism between serum factor(s) and erythropoietin in inducing murine megakaryocyte colony formation: The synergistic factor in serum is distinct from interleukin-11 and stem cell factor (c-kit ligand). Blood 81:866-67
    • (1993) Blood , vol.81 , pp. 866-867
    • Tsukada, J.1    Misago, M.2    Ogawa, R.3
  • 45
    • 0022624954 scopus 로고
    • A retrovirus complex inducing an acute myeloproliferative leukemia disorder in mice
    • Wendling F, Varlet P, Charon M, et al. 1986. A retrovirus complex inducing an acute myeloproliferative leukemia disorder in mice. Virology 149:242-46
    • (1986) Virology , vol.149 , pp. 242-246
    • Wendling, F.1    Varlet, P.2    Charon, M.3
  • 46
    • 0025674093 scopus 로고
    • A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors
    • Souyri M, Vigon I, Penciolelli J-F, et al. 1990. A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors. Cell 63:1137-47
    • (1990) Cell , vol.63 , pp. 1137-1147
    • Souyri, M.1    Vigon, I.2    Penciolelli, J.-F.3
  • 47
    • 0026684707 scopus 로고
    • Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: Identification of a member of the hematopoietic growth factor receptor superfamily
    • Vigon I, Mornon J-P, Cocault L, et al. 1992. Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily. Proc. Natl. Acad Sci. USA 89: 5640-44
    • (1992) Proc. Natl. Acad Sci. USA , vol.89 , pp. 5640-5644
    • Vigon, I.1    Mornon, J.-P.2    Cocault, L.3
  • 48
    • 0027232919 scopus 로고
    • The hematopoietin receptor superfamily
    • Cosman D. 1993. The hematopoietin receptor superfamily. Cytokine 5:95-106
    • (1993) Cytokine , vol.5 , pp. 95-106
    • Cosman, D.1
  • 49
    • 0028117163 scopus 로고
    • Cytokine signal transduction
    • Kishimoto T, Taga T, Akira S. 1994. Cytokine signal transduction. Cell 76:253-62
    • (1994) Cell , vol.76 , pp. 253-262
    • Kishimoto, T.1    Taga, T.2    Akira, S.3
  • 50
    • 0025323368 scopus 로고
    • Regulation of megakaryocyte phenotype in human erythroleukemia cells
    • Long MW, Heffner CH, Williams JL, et al. 1990. Regulation of megakaryocyte phenotype in human erythroleukemia cells. J. Clin. Invest. 85:1072-84
    • (1990) J. Clin. Invest. , vol.85 , pp. 1072-1084
    • Long, M.W.1    Heffner, C.H.2    Williams, J.L.3
  • 51
    • 0027257805 scopus 로고
    • Expression of the c-mpl proto-oncogene in human hematologic malignancies
    • Vigon I, Dreyfus F, Melle J, et al. 1993. Expression of the c-mpl proto-oncogene in human hematologic malignancies. Blood 82:877-83
    • (1993) Blood , vol.82 , pp. 877-883
    • Vigon, I.1    Dreyfus, F.2    Melle, J.3
  • 52
    • 0027225872 scopus 로고
    • Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis
    • Methia N, Louache F, Vainchenker W, et al. 1993. Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis. Blood 82:1395-401
    • (1993) Blood , vol.82 , pp. 1395-1401
    • Methia, N.1    Louache, F.2    Vainchenker, W.3
  • 53
    • 0028332474 scopus 로고
    • Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin
    • Kaushansky K, Lok S, Holly RD, et al. 1994. Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature 369: 568-71
    • (1994) Nature , vol.369 , pp. 568-571
    • Kaushansky, K.1    Lok, S.2    Holly, R.D.3
  • 54
    • 0028114123 scopus 로고
    • In vitro megakaryocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells
    • Zeigler FC, de Sauvage F, Widmer HR, et al. 1994. In vitro megakaryocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells. Blood 84:4045-52
    • (1994) Blood , vol.84 , pp. 4045-4052
    • Zeigler, F.C.1    De Sauvage, F.2    Widmer, H.R.3
  • 55
    • 0028176283 scopus 로고
    • c-Mpl ligand is a humoral regulator of megakaryocytopoiesis
    • Wendling F, Maraskovsky E, Debili N, et al. 1994. c-Mpl ligand is a humoral regulator of megakaryocytopoiesis. Nature 369: 571-74
    • (1994) Nature , vol.369 , pp. 571-574
    • Wendling, F.1    Maraskovsky, E.2    Debili, N.3
  • 56
    • 0029037953 scopus 로고
    • The Mpl igand or thrombopoietin or megakaryocyte growth and differentiative factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors
    • Debili N, Wendling F, Katz A, et al. 1995. The Mpl igand or thrombopoietin or megakaryocyte growth and differentiative factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors. Blood 86:2516-25
    • (1995) Blood , vol.86 , pp. 2516-2525
    • Debili, N.1    Wendling, F.2    Katz, A.3
  • 57
    • 0028985594 scopus 로고
    • Thrombopoietin, the Mpl-ligand, is essential for full megakaryocyte development
    • Kaushansky K, Broudy VC, Lin N, et al. 1995. Thrombopoietin, the Mpl-ligand, is essential for full megakaryocyte development. Proc. Natl. Acad. Sci. USA 92: 3234-38
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3234-3238
    • Kaushansky, K.1    Broudy, V.C.2    Lin, N.3
  • 58
    • 0028928884 scopus 로고
    • Platelets generated in vitro from pro-platelet-displaying human megakaryocytes are functional
    • Choi ES, Nichol JL, Hokom MM, et al. 1995. Platelets generated in vitro from pro-platelet-displaying human megakaryocytes are functional. Blood 85:402-13
    • (1995) Blood , vol.85 , pp. 402-413
    • Choi, E.S.1    Nichol, J.L.2    Hokom, M.M.3
  • 59
    • 0029046966 scopus 로고
    • Megakaryocyte growth and development factor: Analysis of in vitro effects on human megakaryopoiesis and endogenous serum levels during chemotherapy induced thrombocytopenia
    • Nichol J, Hokom M, Hornkohl A, et al. 1995. Megakaryocyte growth and development factor: analysis of in vitro effects on human megakaryopoiesis and endogenous serum levels during chemotherapy induced thrombocytopenia. J. Clin. Invest. 95: 2973-78
    • (1995) J. Clin. Invest. , vol.95 , pp. 2973-2978
    • Nichol, J.1    Hokom, M.2    Hornkohl, A.3
  • 60
    • 0030048887 scopus 로고    scopus 로고
    • Thrombopoietin in thrombocytopenic mice: Evidence against regulation at the mRNA level and for a direct regulatory role of platelets
    • Stoffel R, Wiestner A, Skoda R. 1996. Thrombopoietin in thrombocytopenic mice: evidence against regulation at the mRNA level and for a direct regulatory role of platelets. Blood 87:567-73
    • (1996) Blood , vol.87 , pp. 567-573
    • Stoffel, R.1    Wiestner, A.2    Skoda, R.3
  • 61
    • 0029881744 scopus 로고    scopus 로고
    • Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction
    • Emmons RVB, Reid DM, Cohen RL, et al. 1996. Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction. Blood 87:4068-71
    • (1996) Blood , vol.87 , pp. 4068-4071
    • Emmons, R.V.B.1    Reid, D.M.2    Cohen, R.L.3
  • 62
    • 8044228496 scopus 로고
    • Inappropriate elevation and loss of feedback regulation of thrombopoietin in essential thrombocythaemia
    • Taylor K, Pitcher L, Nichol J, et al. 1995. Inappropriate elevation and loss of feedback regulation of thrombopoietin in essential thrombocythaemia. Blood 86(Suppl. 1):49a
    • (1995) Blood , vol.86 , Issue.1 SUPPL.
    • Taylor, K.1    Pitcher, L.2    Nichol, J.3
  • 63
    • 0029150347 scopus 로고
    • Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy
    • Kaushansky K, Broudy VC, Grossmann A, et al. 1995. Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy. J. Clin. Invest. 96:1683-87
    • (1995) J. Clin. Invest. , vol.96 , pp. 1683-1687
    • Kaushansky, K.1    Broudy, V.C.2    Grossmann, A.3
  • 64
    • 0029027918 scopus 로고
    • Recombinant human thrombopoietin (Mpl ligand) enhances proliferation of erythroid progenitors
    • Kobayashi M, Laver JH, Kato T, et al. 1995. Recombinant human thrombopoietin (Mpl ligand) enhances proliferation of erythroid progenitors. Blood 86:2494-99
    • (1995) Blood , vol.86 , pp. 2494-2499
    • Kobayashi, M.1    Laver, J.H.2    Kato, T.3
  • 65
    • 0030039567 scopus 로고    scopus 로고
    • Thrombopoietin, the ligand for the Mpl receptor, synergy with steel factor and other early-acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice
    • Ku H, Yonemura Y, Kaushansky K, et al. 1996. Thrombopoietin, the ligand for the Mpl receptor, synergy with steel factor and other early-acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice. Blood 87:4544-51
    • (1996) Blood , vol.87 , pp. 4544-4551
    • Ku, H.1    Yonemura, Y.2    Kaushansky, K.3
  • 66
    • 0030014681 scopus 로고    scopus 로고
    • The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells
    • Sitnicka E, Lin N, Priestley GV, et al. 1996. The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells. Blood 87:4998-5005
    • (1996) Blood , vol.87 , pp. 4998-5005
    • Sitnicka, E.1    Lin, N.2    Priestley, G.V.3
  • 67
    • 0028909690 scopus 로고
    • Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and IL-11 to enhance murine MK colony growth and increases MK ploidy in vitro
    • Broudy VC, Lin NL, Kaushansky K. 1995. Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and IL-11 to enhance murine MK colony growth and increases MK ploidy in vitro. Blood 85:1719-26
    • (1995) Blood , vol.85 , pp. 1719-1726
    • Broudy, V.C.1    Lin, N.L.2    Kaushansky, K.3
  • 68
    • 0009749395 scopus 로고
    • Granulocyte colony-stimulating factor enhances interleukin 3-dependent proliferation of multipotential hemopoietic progenitors
    • Ikebuchi K, Clark SC, Ihle JN, et al. 1988. Granulocyte colony-stimulating factor enhances interleukin 3-dependent proliferation of multipotential hemopoietic progenitors. Proc. Natl. Acad. Sci. USA 85: 3445-49
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 3445-3449
    • Ikebuchi, K.1    Clark, S.C.2    Ihle, J.N.3
  • 69
    • 0027844991 scopus 로고
    • Mega karyocytic and erythrocytic cell lines share a common precursor cell
    • McDonald TP, Sullivan PS. 1993. Mega karyocytic and erythrocytic cell lines share a common precursor cell. Exp. Hematol. 21:1316-20
    • (1993) Exp. Hematol. , vol.21 , pp. 1316-1320
    • McDonald, T.P.1    Sullivan, P.S.2
  • 70
    • 0029267284 scopus 로고
    • A bipotential megakaryocyte/erythrocyte progenitor cell: The link between erythropoiesis and megakaryopoiesis becomes stronger
    • Hunt P. 1995. A bipotential megakaryocyte/erythrocyte progenitor cell: The link between erythropoiesis and megakaryopoiesis becomes stronger. J. Lab. Clin. Med. 125:303-4
    • (1995) J. Lab. Clin. Med. , vol.125 , pp. 303-304
    • Hunt, P.1
  • 71
    • 0019914177 scopus 로고
    • The effects of thrombopoietin on megakaryocyte-CFC, megakaryocytes, and thrombopoiesis: With studies of ploidy and platelet size
    • Levin J, Levin FC, Hull DF III, et al. 1982. The effects of thrombopoietin on megakaryocyte-CFC, megakaryocytes, and thrombopoiesis: with studies of ploidy and platelet size. Blood 60:989-98
    • (1982) Blood , vol.60 , pp. 989-998
    • Levin, J.1    Levin, F.C.2    Hull III, D.F.3
  • 72
    • 0023254990 scopus 로고
    • Regulation of thrombopoiesis: Effects of the degree of thrombocytopenia on megakaryocyte ploidy and platelet volume
    • Corash L, Chen HY, Levin J, et al. 1987. Regulation of thrombopoiesis: effects of the degree of thrombocytopenia on megakaryocyte ploidy and platelet volume. Blood 70:177-85
    • (1987) Blood , vol.70 , pp. 177-185
    • Corash, L.1    Chen, H.Y.2    Levin, J.3
  • 73
    • 0025177216 scopus 로고
    • Regulation of megakaryocyte ploidy in vivo in the rat
    • Kuter DJ, Rosenberg RD. 1990. Regulation of megakaryocyte ploidy in vivo in the rat. Blood 75:74-81
    • (1990) Blood , vol.75 , pp. 74-81
    • Kuter, D.J.1    Rosenberg, R.D.2
  • 74
    • 0029960265 scopus 로고    scopus 로고
    • Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietin receptor c-Mpl
    • Alexander WS, Roberts AW, Nicola NA, et al. 1996. Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietin receptor c-Mpl. Blood 87:2162-70
    • (1996) Blood , vol.87 , pp. 2162-2170
    • Alexander, W.S.1    Roberts, A.W.2    Nicola, N.A.3
  • 75
    • 0346932064 scopus 로고
    • Deficiencies in early and late stages of megakaryocytopoiesis in TPO-KO mice
    • de Sauvage FJ, Luoh S-M, Carver-Moore K, et al. 1995. Deficiencies in early and late stages of megakaryocytopoiesis in TPO-KO mice. Blood 86:255a
    • (1995) Blood , vol.86
    • Sauvage, F.J.1    Luoh, S.-M.2    Carver-Moore, K.3
  • 76
    • 0029062371 scopus 로고
    • Recombinant human megakaryocyte growth and development factor stimulates thrombocytosis in normal nonhuman primates
    • Farese AM, Hunt P, Boone T, et al. 1995. Recombinant human megakaryocyte growth and development factor stimulates thrombocytosis in normal nonhuman primates. Blood 86:54-59
    • (1995) Blood , vol.86 , pp. 54-59
    • Farese, A.M.1    Hunt, P.2    Boone, T.3
  • 77
    • 4243650211 scopus 로고
    • Recombinant thrombopoietin stimulates rapid platelet recovery in thrombocytopenic mice
    • Sprugel KH, Humes JM, Grossmann A, et al. 1994. Recombinant thrombopoietin stimulates rapid platelet recovery in thrombocytopenic mice. Blood 84(Suppl. 1): 242a
    • (1994) Blood , vol.84 , Issue.1 SUPPL.
    • Sprugel, K.H.1    Humes, J.M.2    Grossmann, A.3
  • 78
    • 0029051730 scopus 로고
    • Megakaryocyte growth and development factor ameliorates carboplatin-induced thrombocytopenia in mice
    • Ulich TR, del Castillo J, Yin S, et al. 1995. Megakaryocyte growth and development factor ameliorates carboplatin-induced thrombocytopenia in mice. Blood 86: 971-76
    • (1995) Blood , vol.86 , pp. 971-976
    • Ulich, T.R.1    Del Castillo, J.2    Yin, S.3
  • 79
    • 0028803099 scopus 로고
    • Pegylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carbo platin and irradiation in mice
    • Hokom MM, Lacey D, Kintsler OB, et al. 1995. Pegylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carbo platin and irradiation in mice. Blood 86: 4486-92
    • (1995) Blood , vol.86 , pp. 4486-4492
    • Hokom, M.M.1    Lacey, D.2    Kintsler, O.B.3
  • 80
    • 0011927810 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled phase I trial of pegylated megakaryocyte growth and development factor administered to patients with advanced cancer after chemotherapy
    • Begley G, Basser R, Clarke K, et al. 1996. Randomized, double-blind, placebo-controlled phase I trial of pegylated megakaryocyte growth and development factor administered to patients with advanced cancer after chemotherapy. Proc. ASCO 15: 271
    • (1996) Proc. ASCO , vol.15 , pp. 271
    • Begley, G.1    Basser, R.2    Clarke, K.3
  • 81
    • 1842269190 scopus 로고    scopus 로고
    • Safety and biological effects of pegylated megakaryocyte growth and development factor in lung cancer patients receiving carboplatin and paclitaxel: Randomized, placebo-controlled phase I study
    • Fannucchi M, Glaspy J, Crawford J, et al. 1996. Safety and biological effects of pegylated megakaryocyte growth and development factor in lung cancer patients receiving carboplatin and paclitaxel: randomized, placebo-controlled phase I study. Proc. ASCO 15:271
    • (1996) Proc. ASCO , vol.15 , pp. 271
    • Fannucchi, M.1    Glaspy, J.2    Crawford, J.3
  • 82
    • 0342569563 scopus 로고    scopus 로고
    • Single-dose therapy with recombinant human thrombopoietin (rhTPO) in patients receiving cytotoxic chemotherapy
    • Vadhan-Raj S, Burris H, Benjamin RS, et al. 1996. Single-dose therapy with recombinant human thrombopoietin (rhTPO) in patients receiving cytotoxic chemotherapy. Proc. ASCO 15:24
    • (1996) Proc. ASCO , vol.15 , pp. 24
    • Vadhan-Raj, S.1    Burris, H.2    Benjamin, R.S.3


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