Differential A1-adenosine receptor reserve for inhibition of cyclic AMB accumulation and G-protein activation in DDT1 MF-2 cells

British Journal of Pharmacology

Volumn 130, Issue 5, 2000, Pages 1156-1164

  Baker, Stephen P ^a   Scammells, Peter J ^b   Belardinelli, Luiz ^a,c  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b DEAKIN UNIVERSITY   (Australia)

^c CV THERAPEUTICS INC   (United States)

Author keywords

8 Cyclopentyl 3 3 4(fluorosulphonyl)benzoyl oxy propyl 1 propylxanthine (FSCPX); Cyclic AMP; G protein; Irreversible antagonist; Receptor reserve

Indexed keywords

ADENOSINE A1 RECEPTOR; ADENYLATE CYCLASE; CYCLIC AMP; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); ISOPRENALINE; MEMBRANE RECEPTOR; XANTHINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; ISOTOPE LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SCATCHARD PLOT;

EID: 0033922489     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703405     Document Type: Article

References (43)

1. 1B receptor expression system. Mol. Pharmacol., 43, 427-433.
2. 35S]thio)triphosphate binding by endogenous opioids acting at a cloned Mu receptor. J. Pharmacol. Exp. Ther., 286, 282-288.
3. BAKER, S.B. & DEYRUP, M.D. (1994). Development of novel irreversible antagonists. Neuroprotocols, 4, 66-75.
4. BOKOCH, G.M., KATADA, T., NORTHUP, J.K., UI, M. & GILMAN, A.G. (1984). Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. J. Biol. Chem., 259, 3560-3567.
5. BRADFORD, M.M. (1976). A rapid and sensitive method for the quantitation of microgram quanties of protein utilizing the principle of protein dye binding. Anal. Biochem., 72, 248-254.
6. 35S]GTPγS binding to rat cerebellar membranes correlates with agonist-induced decreases in GDP affinity. J. Biol. Chem., 273, 16865-16873.
7. BREIVOGEL, C.S., SIM, L.J. & CHILDERS, S.R. (1997). Regional differences in cannabinoid receptor/G-protein coupling in rat brain. J. Pharmacol. Exp. Ther., 282, 1632-1642.
8. BROWN, L., DEIGHTON, N.M., BALS, S., SOHLMANN, W., ZERKOWSKI, H.-R., MICHEL, M.C. & BRODDE, O.-E. (1992). Spare receptors for β-adrenoceptor-mediated positive inotropic effects of catecholamines in the human heart. J. Cardiovasc. Pharmacol., 19, 222-232.
9. BROWN, J.H. & GOLDSTEIN, D. (1986). Differences in muscarinic receptor reserve for inhibition of adenylate cyclase and stimulation of phosphoinositide hydrolysis in chick heart cells. Mol. Pharmacol., 30, 566-570.
10. 1-adenosine receptors in guinea pig atrioventricular node. Am. J. Physiol., 262, H661-H671.
11. FURCHGOTT, R.F. & BURSZTYN, P. (1967). Comparison of dissociation constants and of relative efficacies of selected agonists acting on parasympathetic receptors. Ann. New York Acad. Sci., 144, 882-899.
12. 1 MF-2 smooth muscle cells. Mol. Pharmacol., 40, 149-155.
13. 1 MF-2 smooth muscle cells. Proc. Natl. Acad. Sci. U.S.A., 89, 7330-7334.
14. 1 MF-2 smooth muscle cells. Mol. Pharmacol., 38, 660-666.
15. GIERSCHIK, P., MOGHTADER, R., STRAUB, C., DIETERICH, K. & JAKOBS, K.H. (1991). Signal amplification in HL-60 granulocytes. Evidence that the chemotactic peptide receptor catalytically activates guanine-nucleotide-binding regulatory proteins in native plasma membranes. Eur. J. Biochem., 197, 725-732.
16. GILMAN, A.G. (1987). G proteins: transducers of receptor-generated signals. Ann. Rev. Biochem., 56, 615-649.
17. HARPER, J.F. & BROOKER, G. (1975). Femtomole sensitive radio-immunoassay for cyclic AMP and cyclic GMP after 2′O acetylation by acetic anhydride in aqueous solution. J. Cyclic Nucleotide Res., 1, 207-218.
18. HILF, G., GIERSCHIK, P. & JAKOBS, K.H. (1989). Muscarinic acetylcholine receptor-stimulated binding of guanosine 5′-O-(3-thiophosphate) to guanine-nucleotide-binding proteins in cardiac membranes. Eur. J. Biochem., 186, 725-731.
19. 1 adenosine receptors. J. Med. Chem., 32, 1043-1051.
20. JASPER, J.R.M., MOTULSKY, H.J. & INSEL, P.A. (1988). Characterization of a bromoacetylated derivative of pindolol as a high affinity, irreversible beta adrenergic antagonist in cultured cells. J. Pharmacol. Exp. Ther., 244, 820-824.
21. KEEN, M. & NAHORSKI, S.R. (1988). Muscarinic acetylcholine receptors linked to the inhibition of adenylate cyclase activity in membranes from the rat striatum and myocardium can be distinguished on the basis of agonist efficacy. Mol. Pharmacol., 34, 769-778.
22. KENAKIN, T. (1993). Pharmacologic Analysis of Drug-Receptor Interaction, pp. 44-57. New York: Raven Press.
23. 1 adenosine receptor from rat brain membranes. J. Neurochem., 46, 1528-1534.
24. 35S]thio)triphosphate binding. Mol. Pharmacol., 44, 115-123.
25. 1 adenosine receptor with receptor/G protein complexes in rat brain membranes. Mol. Pharmacol., 49, 915-926.
26. MELLER, E., BOHMAKER, K., NAMBA, Y., FRIEDHOFF, A.J. & GOLDSTEIN, M. (1987). Relationship between receptor occupancy and response at striatal dopamine autoreceptors. Mol. Pharmacol., 31, 592-598.
27. 1-adenosine receptor reserve in guinea-pig atrium. Br. J. Pharmacol., 123, 1425-1433.
28. 1 adenosine receptor/G protein coupling: identification of a membrane protein that stabilizes the association of the receptor/G protein complex. Mol. Pharmacol., 48, 806-817.
29. NEUBIG, R.R. (1994). Membrane organization in G-protein mechanisms. FASEB J., 8, 939-946.
30. 2-receptor affinity and decreased receptor reserve in rat isolated coronary arteries. Br. J. Pharmacol., 102, 282-286.
31. 125I-labeled succinyl cyclic nucleotide tyrosine methyl esters by high-performance liquid chromatography. Anal. Biochem., 168, 417-420.
32. PFEUFFER, T. & HELMREICH, E.J.M. (1975). Activation of pigeon erythrocyte membrane adenylate cyclase by guanyl nucleotide analogues and separation of a nucleotide binding protein. J. Biol. Chem., 250, 867-876.
33. 1 MF-2 smooth muscle cells. Mol. Pharmacol., 37, 149-156.
34. 2-adrenoceptors, for respective vasopressor effects of cirazoline and B-HT 933 in the pithed rat. J. Cardiovasc. Pharmacol., 6, 1011-1019.
35. 1 adenosine receptors. J. Med. Chem., 37, 2704-2712.
36. SCATCHARD, G. (1949). The attractions of proteins for small molecules and ions. Ann. NY Acad. Sci., 51, 660-672.
37. SIM, L.J., SELLEY, D.E., XIAO, R. & CHILDERS, S.R. (1996). Differences in G-protein activation by μ-and δ-opioid, and cannabinoid receptors in rat striatum. Eur. J. Pharmacol. 307, 97-105.
38. 1 adenosine receptor reserve for two actions of adenosine on guinea pig atrial myocytes. Mol. Pharmacol., 52, 683-691.
39. 1-adenosine receptor. Mol. Pharmacol., 50, 196-205.
40. 1 adenosine receptor-G protein coupling in bovine brain membranes: effects of guanine nucleotides, salt and solubilization. J. Neurochem., 51, 1592-1598.
41. 35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells. Mol. Pharmacol., 47, 848-854.
42. YANG, Q. & LANIER, S.M. (1999). Influence of G protein type on agonist efficacy. Mol. Pharmacol., 56, 651-656.
43. 1 MF-2 cells and in guinea pig heart. Mol. Pharmacol., 52, 491-498.