Studies on cerebral protective agents. X. Synthesis and evaluation of anticonvulsant activities for novel 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and related compounds

Chemical and Pharmaceutical Bulletin

Volumn 44, Issue 4, 1996, Pages 778-784

  Ohkubo, Mitsuru ^a   Kuno, Atsushi ^a   Katsuta, Kiyotaka ^a   Ueda, Yoshiko ^a   Shirakawa, Kiyoharu ^a   Nakanishi, Hajime ^a   Kinoshita, Takayoshi ^a   Takasugi, Hisashi ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Anticonvulsant; FR115427; N methyl D aspartate; Structure activity relationship; Tetrahydroisoquinoline; Tetrahydrothieno 3,2 c pyridine

Indexed keywords

1,2,3,4 TETRAHYDRO 1 METHYL 1 (2 THIENYL)ISOQUINOLINE; 4,5,6,7 TETRAHYDRO 4 METHYL 4 (2 THIENYL)THIENO[3,2 C]PYRIDINE; 4,5,6,7 TETRAHYDRO 4 METHYL 4 PHENYLTHIENO[3,2 C]PYRIDINE; ANTICONVULSIVE AGENT; N METHYL DEXTRO ASPARTIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; BRAIN PROTECTION; CONFORMATIONAL TRANSITION; CONVULSION; DRUG CONFORMATION; DRUG SYNTHESIS; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANOXIA; ANTICONVULSANTS; CONVULSANTS; EXCITATORY AMINO ACID AGONISTS; INJECTIONS, INTRAVENTRICULAR; MALE; MICE; MICE, INBRED ICR; N-METHYLASPARTATE; PYRIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES; X-RAY DIFFRACTION;

EID: 0029967563     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.44.778     Document Type: Review

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