Control of cellular phosphatidylinositol 4,5-bisphosphate levels by adhesion signals and Rho GTpases in NIH 3t3 fibroblasts: Involvement of both phosphatidylinositol-4-phosphate 5-kinase and phospholipase C

European Journal of Biochemistry

Volumn 267, Issue 16, 2000, Pages 5237-5246

  Oude Weernink, Paschal A ^a   Guo, Yuanjian ^a   Zhang, Chunyi ^a,c   Schmidt, Martina ^a   Von Eichel Streiber, Christoph ^b   Jakobs, Karl H ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

Adhesion; Clostridial toxins; Phosphatidylinositol 4,5 bisphosphate; Phospholipase C; Rho proteins

Indexed keywords

CLOSTRIDIUM DIFFICILE TOXIN B; GUANOSINE TRIPHOSPHATASE; INOSITOL PHOSPHATE; PHOSPHATIDYLINOSITOL 4 PHOSPHATE KINASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOLIPASE C; RHO FACTOR;

ANIMAL CELL; ARTICLE; CELL ADHESION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME REGULATION; FIBROBLAST; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

3T3 CELLS; ANIMALS; BACTERIAL PROTEINS; BACTERIAL TOXINS; CALCIUM; CELL ADHESION; CYTOTOXINS; KINETICS; MICE; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHOLIPASE C; PHOSPHORIC DIESTER HYDROLASES; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RAC1 GTP-BINDING PROTEIN; RECOMBINANT PROTEINS; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 0033892140     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2000.01599.x     Document Type: Article

References (58)

1. The synthesis and cellular roles of phosphatidylinositol 4,5-bisphosphate
2. Regulation of phosphoinositide-specific phospholipase C isozymes
3. The role of phosphoinositide 3-kinase lipid products in cell function
4. Phosphoinositides and calcium as regulators of cellular actin assembly and disassembly
5. Regulation of vinculin binding to talin and actin by phosphatidylinositol-4,5-bisphosphate
6. Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase
7. Functional interaction of ADP-ribosylation factor 1 with phosphatidylinositol 4,5-bisphosphate
8. Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate
9. Phosphoinosifide kinases
10. Glucosylation of Rho proteins by Clostridium difficile toxin B
11. A role for Rho in receptor- and G protein-stimulated phospholipase C. Reduction in phosphafidylinositol 4,5-bisphosphate by Clostridium difficile toxin B
12. Tyrosine-phosphorylation-dependent and Rho-protein-mediated control of cellular phosphatidylinositol 4,5-bisphosphate levels
13. Inhibition by toxin B of inositol phosphate formation induced by G protein-coupled and tyrosine kinase receptors in N1E-I15 neuroblastoma cells: Involvement of Rho proteins
14. Rho GTPases and the actin cytoskeleton
15. Signal transduction and signal modulation by cell adhesion receptors: The role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins
16. Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown
17. + antiporter by platelet-derived growth factor
18. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
19. Transformation by Rho exchange factor oncogenes is mediated by activation of an integrin-dependent pathway
20. Large clostridial cytotoxins: A family of glycosyltransferases modifying small GTP-binding proteins
21. Specific inhibition of phorbol ester-stimulated phospholipase D by Clostridium sordellii lethal toxin and Clostridium difficile toxin B-1470 in HEK-293 cells
22. Purification of two high molecular weight toxins of Clostridium difficile which are antigenically related
23. Closing in on the toxic domain through analysis of a variant Clostridium difficile cytotoxin B
24. A role for Rho-kinase in Rho-controlled phospholipase D stimulation by the m3 muscarinic acetylcholine receptor
25. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
26. Protein kinase cross-talk: Membrane targeting of the β-adrenergic receptor kinase by protein kinase C
27. The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells
28. Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands
29. Guanosine 5'-[gamma-thio]triphosphate-stimulated hydrolysis of phosphatidylinositol 4,5-bisphosphate in HL-60 granulocytes: Evidence that the guanine nucleotide acts by relieving phospholipase C from an inhibitory constraint
30. Clostridium difficile toxin B acts on the GTP-binding protein Rho
31. Inhibition of receptor signaling to phospholipase D by Clostridium difficile toxin B
32. Restoration of Clostridium difficile toxin B-inhibited phospholipase D by phosphatidylinositol 4,5-bisphosphate
33. Phosphatidic acid is a specific activator of phosphatidylinositol-4-phosphate kinase
34. Type I phosphatidylinositol 4-phosphate 5-kinase isoforms are specifically stimulated by phosphatidic acid
35. Rho family GTPases bind to phosphoinositide kinases
36. Physical association of the small GTPase Rho with a 68-kDa phosphatidylinositol 4-phosphate 5-kinase in Swiss 3T3 cells
37. Regulation of inositol lipid kinases by Rho and Rac
38. Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets
39. Aggregation-dependent, integrin-mediated increases in cytoskeletally associated PtdlnsP2 (4,5) levels in human platelets are controlled by translocation of PtdIns 4-P 5-kinase C to the cytoskeleton
40. Convergence of integrin and growth factor receptor signalling pathways within the focal adhesion complex
41. Phosphatidylinositol 4-phosphate 5-kinase α is a downstream effector of the small G protein ARF6 in membrane raffle formation
42. 2 on the Golgi complex
43. Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family
44. Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol-4-phosphate 5-kinase
45. Type I phosphatidylinositol-4-phosphate 5-kinases
46. Massive actin polymerization induced by phosphatidylinositol-4-phosphate 5-kinase in vivo
47. Type Iα phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly
48. The mammalian G protein RhoC is ADP-ribosylated by Clostridium botulinum C3 and affects actin microfilaments in Veto cells
49. Clostridium difficile toxin B activates calcium influx required for actin disassembly during cytotoxicity
50. Role of the cytoskeleton in calcium signaling in NIH 3T3 cells
51. A dual functional signal mediator showing RhoGAP and phospholipase C-δ stimulating activities
52. Stimulation of phospholipase C-β2 by the Rho GTPase: Cdc42Hs and Racl
53. 3/calcium pathway in RBL-2H3 mast cells
54. The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases
55. Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton
56. Requirement for Rho in integrin signaling
57. Activation of Rac and Cdc42 by integrins mediates cell spreading
58. Integrin-mediated signals regulated by members of the Rho family of GTPases