The development of bleomycin-induced pulmonary fibrosis in mice deficient for components of the fibrinolytic system

American Journal of Pathology

Volumn 157, Issue 1, 2000, Pages 177-187

  Swaisgood, Carmen M ^a   French, Esther L ^a   Noga, Chris ^a   Simon, Richard H ^b   Ploplis, Victoria A ^c  

^a LERNER RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; PLASMINOGEN; PLASMINOGEN ACTIVATOR; TISSUE PLASMINOGEN ACTIVATOR; UROKINASE; UROKINASE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG INDUCED DISEASE; FEMALE; FIBRIN DEPOSITION; FIBRINOLYSIS; GENE OVEREXPRESSION; LUNG FIBROSIS; LUNG HEMORRHAGE; LUNG INJURY; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL;

EID: 0033872052     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64529-4     Document Type: Article

References (58)

1. Pathology of pulmonary fibrosis
2. Interstitial pulmonary fibrosis: Which cell is the culprit?
3. On the regulation and control of fibrinolysis
4. Effects of disruption of the plasminogen gene in mice on thrombosis, growth, and health
5. Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction
6. Impaired wound healing in mice with a disrupted plasminogen gene
7. Plasminogen deficiency differentially affects recruitment of inflammatory cell populations in mice
8. Studies of mice lacking plasminogen activator gene function suggest that plasmin production prior to ovulation exceeds the amount needed for optimal ovulation efficiency
9. Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation
10. Growth and dissemination of Lewis lung carcinoma in plasminogen-deficient mice
11. Polyoma middle T-induced vascular tumor formation: The role of the plasminogen activator/plasmin system
12. Physiological consequences of loss of plasminogen activation gene function in mice
13. Restoration of thrombolytic potential in plasminogen-deficient mice by bolus administration of plasminogen
14. Chemotaxis for human monocytes by fibrinogen-derived peptides
15. The role of fibrin degradation products in neutrophil recruitment to the lung
16. Plasmin is a potent and specific chemoattractant for human peripheral monocytes acting via a cyclic guanosine monophosphate-dependent pathway
17. Activation mechanisms of matrix metalloproteinases
18. Matrix metalloproteinases: A review
19. Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene
20. Partial reversal of established bleomycin-induced pulmonary fibrosis by rh-urokinase in a rat model
21. Treatment of bleomycin-induced pulmonary fibrosis by transfer of urokinase-type plasminogen activator genes
22. Generation and characterization of urokinase receptor-deficient mice
23. The receptor for urokinase-type plasminogen activator is not essential for mouse development or fertility
24. Pulmonary inflammation induced by incomplete or inactivated adenoviral particles
25. Stepwise activation of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl) mercurin acetate
26. Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase
27. Abnormalities of pathways of fibrin turnover in lung lavage of rats with oleic acid and bleomycin-induced lung injury support alveolar fibrin deposition
28. Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome
29. Local abnormalities of coagulation and fibrinolytic pathways that promote alveolar fibrin deposition in the lungs of baboons with diffuse alveolar damage
30. Bleomycin-induced pulmonary fibrosis: Effects of steroid on lung collagen metabolism
31. The pathogenesis of bleomycin-induced pulmonary fibrosis
32. Urokinase is required for the pulmonary inflammatory response to Cryptococcus neoformans
33. Urokinase receptor (CD87) regulates leukocyte recruitment via beta 2 integrins in vivo
34. Early detection of bleomycin-induced lung injury in rat using indium-111-labeled antibody directed against intercellular adhesion molecule-1
35. Immunochemical study of metallo-proteinases and their tissue inhibitors in the lungs of patients with diffuse alveolar damage and idiopathic pulmonary fibrosis
36. Differential expression of extracellular matrix remodeling genes in a murine model of bleomycin-induced pulmonary fibrosis
37. Proteinases and proteinase inhibitors during the development of pulmonary fibrosis in rats
38. Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice
39. Elastolytic metalloproteinases produced by human mononuclear phagocytes: Potential roles in destructive lung disease
40. Role of urokinase in the fibrogenic response of the lung to mineral particles
41. Monocyte-macrophage release of IL-1 is inhibited by type-1 plasminogen activator inhibitors
42. The role of cell-associated interleukin-1 in bleomycin-induced pulmonary fibrosis
43. Endogenously produced urokinase amplifies tumor necrosis factor-alpha secretion by THP-1 mononuclear phagocytes
44. Polymerization of fibrinogen in murine bleomycin-induced lung injury
45. Fibroblast migration in fibrin gel matrices
46. Aα and Bβ chains of fibrinogen stimulate proliferation of human fibroblasts