Adhesion proteins in the biology of breast cancer: Contribution of CD44

Experimental and Molecular Pathology

Volumn 66, Issue 2, 1999, Pages 149-156

  Herrera Gayol, A ^a   Jothy, S ^b,c  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c SUNNYBROOK RESEARCH INSTITUTE   (Canada)

Author keywords

Breast cancer; Cell adhesion; Diagnosis; Prognosis; Tumor marker; Tumorigenesis

Indexed keywords

CELL ADHESION MOLECULE; HERMES ANTIGEN;

ANTIGEN EXPRESSION; BREAST CANCER; BREAST EPITHELIUM; CANCER INVASION; CELL MOTILITY; EXON; EXTRACELLULAR MATRIX; GENE OVEREXPRESSION; HUMAN; MALIGNANT TRANSFORMATION; METASTASIS; PROGNOSIS; REVIEW; TUMOR GROWTH;

EID: 0032791736     PISSN: 00144800     EISSN: None     Source Type: Journal    
DOI: 10.1006/exmp.1999.2251     Document Type: Review

References (63)

1. Arch R., Wirth K., Hofmann M., Ponta H., Matzku S., Herrlich P., Zöller M. Participation in normal immune response of a metastasis-inducing splice variant of CD44. Science. 257:1992;682-685.
2. Aruffo A., Stamenkovic I., Melnick M., Underhill C. B., Seed B. CD44 is the principal cell surface receptor for hyaluronate. Cell. 61:1990;1303-1313.
3. Auvinen P. K., Parkkinen J. J., Johansson R. T., Agren U. M., Tammi R. H., Eskelinen M. J., Kosma V. M. Expression of hyaluronan in benign and malignant breast lesions. Int. J. Cancer. 74:1997;477-481.
4. Bae S-N., Arand G., Azzam H., Pavasant P., Torri J., Frandsen T. L., Thompson E. W. Molecular and cellular analysis of basement membrane invasion by human breast cancer cells in Matrigel-based in vitro assays. Breast Cancer Res. Treat. 24:1993;241-255.
5. Babaï F. Etude ultrastructurale sur la pathogenie de l'invasion du muscle strie par des tumeurs transplantables. J. Ultrastruct. Res. 56:1976;287-303.
6. Bajorath J., Greenfield B., Munro S. B., Day A. J., Aruffo A. Identification of CD44 residues important for hyaluronan binding and delineation of the binding site. J. Biol. Chem. 273:1998;338-343.
7. Bankfalvi A., Terpe H. J., Breukelmann D., Bier B., Rempe D., Pschadka G., Krech R., Bocker W. Gains and losses of CD44 expression during breast carcinogenesis and tumour progression. Histopathology. 33:1998;107-116.
8. Bartolazzi A., Peach R., Aruffo A., Stamenkovic I. Interaction between CD44 and hyaluronate is directly implicated in the regulation of tumor development. J. Exp. Med. 180:1994;53-66.
9. Bertrand P., Girard N., Delpech B., Duval C., D'Anjou J., Dauce J. P. Hyaluronan (hyaluronic acid) and hyaluronectin in the extracellular matrix of human breast carcinomas: Comparison between invasive and non-invasive areas. Int. J. Cancer. 52:1992;1-6.
10. Bourguignon L. Y. W., Lokeshwar V. B., He J., Chen X., Bourguignon G. J. A CD44-like endothelial cell transmembrane glycoprotein (GP116) interacts with extracellular matrix and ankyrin. Mol. Cell. Biol. 12:1992;4464-4471.
11. Carter W. G., Wayner E. A. Characterization of the class III collagen receptor, a phosphorylated transmembrane glycoprotein expressed in nucleated human cells. J. Biol. Chem. 263:1988;4193-4201.
12. Catzavelos C., Bhattacharya N., Ung Y. C., Wilson J. A., Roncari L., Sandhu C., Shaw P., Yeger H., Morava-Protzner I., Kapusta L., Franssen E., Pritchard K. I., Slingerland J. M. Decreased levels of the cell-cycle inhibitor p27Kip1 protein: Prognostic implications in primary breast cancer. Nature Med. 3:1997;227-230.
13. Chambers A. F., Schmidt E. E., MacDonald I. C., Morris V. L., Groom A. C. Early steps in hematogenous metastasis of B16F1 melanoma cells in chick embryos studied by high-resolution intravital videomicroscopy. J. Natl. Cancer Inst. 84:1992;797-803.
14. Charpin C., Garcia S., Bouvier C., Devictor B., Andrac L., Choux R., Lavaut M. N., Allasia C. Automated and quantitative immunohistochemical assays of CD44v6 in breast carcinomas. Hum. Pathol. 28:1997;289-296.
15. Culty M., Shizari M., Thompson E. W., Underhill C. B. Binding and degradation of hyaluronan by human breast cancer cell lines expressing different forms of CD44: Correlation with invasive potential. J. Cell. Physiol. 160:1994;275-286.
16. Dall P., Heider K. H., Sinn H. P., Skroch-Angel P., Adolf G., Kaufmann M., Herrlich P., Ponta H. Comparison of immunohistochemistry and RT-PCR for detection of CD44v-expression, a new prognostic factor in human breast cancer. Int. J. Cancer. 60:1995;471-477.
17. De la Torre M., Wells A. F., Bergh J., Lindgren A. Localization of hyaluronan in normal breast tissue, radial scar and tubular breast carcinoma. Hum. Pathol. 24:1993;1294-1297.
18. Eckhardt S. G., Pluda J. M. Development of angiogenesis inhibitors for cancer therapy. Invest. New Drugs. 15:1997;1-3.
19. Friedrichs K., Franke F., Lisboa B. W., Kugler G., Gille I., Terpe H. J., Holzel F., Maass H., Günthert U. CD44 isoforms correlate with cellular differentiation but not with prognosis in human breast cancer. Cancer Res. 55:1995;5424-5433.
20. Goebeler M., Kaufmann D., Bröcker E-B., Klein C. E. Migration of highly aggressive melanoma cells on hyaluronic acid is associated with functional changes, increased turnover and shedding of CD44 receptors. J. Cell Sci. 109:1996;1957-1964.
21. Güthert U., Hofmann M., Rudy W., Reber S., Zöauller M., Hau;βmann I., Matzku S., Wenzel A., Ponta H., Herrlich P. A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell. 65:1991;13-24.
22. Guriec N., Marcellin L., Gairard B., Calderoli H., Wilk A., Renaud R., Bergerat J. P., Oberling F. CD44 exon 6 expression as a possible early prognostic factor in primary node negative breast carcinoma. Clin. Exp. Metast. 14:1996;434-439.
23. Haddon C. M., Lewis J. H. Hyaluronan as a propellant for epithelial movement: The development of semicircular canals in the inner ear of Xenopus. Development. 112:1991;541-550.
24. Haynes B. F., Telen M. J., Hale L. P., Denning S. M. CD44-A molecule involved in leukocyte adherence and T-cell activation. Immunol. Today. 10:1989;423-428.
25. Herrera-Gayol A., Jothy S. CD44 modulates Hs578T human breast cancer cell adhesion, migration and invasiveness. Exp. Mol. Pathol. 1999.
26. Ishii S., Ford R., Thomas P., Nachman A., Steele G. Jr., Jessup J. M. CD44 participates in the adhesion of human colorectal carcinoma cells to laminin and type IV collagen. Surg. Oncol. 2:1993;255-264.
27. Jansen R. H., Joosten-Achjanie S. R., Arends J. W., Volovics A., Hupperets P. S., Schouten H. C., Hillen H. F. CD44v6 is not a prognostic factor in primary breast cancer. Ann. Oncol. 9:1998;109-111.
28. Jalkanen S., Jalkanen M. Lymphocyte CD44 binds the COOH-terminal heparin-binding domain of fibronectin. J. Cell Biol. 116:1992;817-825.
29. Joensuu H., Klemi P. J., Toikkanen S., Jalkanen S. Glycoprotein CD44 expression and its association with survival in breast cancer. Am. J. Pathol. 143:1993;867-874.
30. Kaufmann M., Heider K-H., Sinn H-P., von Minckwitz G., Ponta H., Herrlich P. CD44 variant exon epitopes in primary breast cancer and lenght of survival. Lancet. 345:1995;615-619.
31. Knudson C. B., Knudson W. Hyaluronan-binding proteins in development, tissue homeostasis, and disease. FASEB J. 7:1993;1233-1241.
32. Laurent T. C., Fraser J. R. Hyaluronan. FASEB J. 6:1992;2397-2404.
33. Legg J. W., Isacke C. M. Identification and functional analysis of the ezrin-binding site in the hyaluronan receptor, CD44. Curr. Biol. 8:1998;705-708.
34. Liotta L. A. Tumor invasion and metastases - Role of the extracellular matrix: Rhodes Memorial Award lecture. Cancer Res. 46:1986;1-7.
35. Liotta L. A., Kleinerman J., Saidel G. M. The significance of hematogenous tumor cell clumps in the metastatic process. Cancer Res. 36:1976;889-894.
36. Lipponen P., Saarelainen E., Ji H., Aaltomaa S., Syrjänen K. Expression of E-cadherin (E-CD) as related to other prognos tic factors and survival in breast cancer. J. Pathol. 174:1994;101-109.
37. Lokeshwar V. B., Fregien N., Bourguignon L. Y. W. Ankyrin-binding domain of CD44(GP85) is required for the expression of hyaluronic acid-mediated function. J. Cell Biol. 126:1994;1099-1109.
38. Matsumura Y., Tarin D. Significance of CD44 gene prod ucts for cancer diagnosis and disease evaluation. Lancet. 340:1992;1053-1058.
39. Merzak A., Koocheckpour S., Pilkington G. J. CD44 mediates human glioma cell adhesion and invasion. Cancer Res. 54:1994;3988-3992.
40. Neame S. J., Isacke C. M. The cytoplasmic tail of CD44 is required for basolateral localization in epithelial MDCK cells but does not mediate association with the detergent-insoluble cytoskele ton of fibroblasts. J. Cell Biol. 121:1993;1299-1310.
41. Peach R. J., Hollenbaugh D., Stamenkovic I., Aruffo A. Identification of hyaluronic acid binding sites in the extracellular domain of CD44. J. Cell Biol. 122:1993;257-264.
42. Press M. F., Pike M. C., Chazin V. R., Hung G., Udove J. A., Markowicz M., Danyluk J., Godolphin W., Sliwkowski M., Akita R., Paterson M. C., Slamon D. J. Her-2/neu expression in node-negative breast cancer: Direct tissue quantitation by compu terized image analysis and association of overexpression with in creased risk of recurrent disease. Cancer Res. 53:1993;4960-4970.
43. Rodriguez C., Monges G., Rouanet P., Dutrillaux B., Lefrançois D., Theillet C. CD44 expression patterns in breast and colon tumors: A PCR-based study of splice variants. Int. J. Cancer. 64:1995;347-354.
44. Rudzki Z., Jothy S. CD44 and the adhesion of neoplastic cells. J. Clin. Pathol.: Mol. Pathol. 50:1997;57-71.
45. Ruiz P., Schwärzler C., Günthert U. CD44 isoforms during differentiation and development. BioEssays. 17:1995;17-24.
46. Schumacher U., Horny H.-P., Horst H.-A., Herrlich P., Kaiserling E. A CD44 variant exon 6 epitope as a prognostic indicator in breast cancer. Eur. J. Surg. Oncol. 22:1996;259-261.
47. Screaton G. R., Bell M. V., Jackson D. G., Cornelis F. B., Gerth U., Bell J. I. Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons. Proc. Natl. Acad. Sci. USA. 89:1992;12160-12164.
48. Sinn H. P., Heider K. H., Skroch-Angel P., von Minckwitz G., Kaufmann M., Herrlich P., Ponta H. Human mammary carcinomas express homologues of rat metastasis-associated variants of CD44. Breast Cancer Res. Treat. 36:1995;307-313.
49. Sleeman J. P., Kondo K., Moll J., Ponta H., Herrlich P. Variant exons v6 and v7 together expand the repertoire of glycosaminoglycans bound by CD44. J. Biol. Chem. 272:1997;31837-31844.
50. Sommers C. L., Byers S. W., Thompson E. W., Torri J. A., Gelmann E. P. Differentiation state and invasiveness of human breast cancer cell lines. Breast Cancer Res. Treat. 31:1994;325-335.
51. Tempfer C., Losch A., Heinzl H., Hausler G., Hanzal E., Kolbl H., Breitenecker G., Kainz C. Prognostic value of immunohistochemically detected CD44 isoforms CD44v5, CD44v6 and CD44v7-8 in human breast cancer. Eur. J. Cancer. 32A:1996;2023-2025.
52. Thomas L., Byers H. R., Vink J., Stamenkovic I. CD44H regulates tumor cell migration on hyaluronate-coated substrate. J. Cell Biol. 118:1992;971-977.
53. Thompson E. W., Paik S., Brünner N., Sommers C. L., Zugmaier G., Clark R., Shima T. B., Torri J., Donahue S., Lippman M. E., Martin G. R., Dickson R. B. Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines. J. Cell Physiol. 150:1992;534-544.
54. Toi M., Kashitani J., Tominaga T. Tumor angiogenesis is an independent prognostic indicator in primary breast carcinoma. Int. J. Cancer. 55:1993;371-374.
55. Tokue Y., Matsumura Y., Katsumata N., Watanabe T., Tarin D., Kakizoe T. CD44 variant isoform expression and breast cancer prognosis. Jpn. J. Cancer Res. 89:1998;283-290.
56. Trochon V., Mabilat C., Bertrand P., Legrand Y., Smadja-Joffe F., Soria C., Delpech B., Lu H. Evidence of involvement of CD44 in endothelial cell proliferation, migration and angiogenesis in vitro. Int. J. Cancer. 66:1996;664-668.
57. Tsukita S., Oishi K., Sato N., Sagara J., Kawai A., Tsukita S. ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons. J. Cell Biol. 126:1994;391-401.
58. Weber G. F., Ashkar S., Glimcher M. J., Cantor H. Receptor-ligand interaction between CD44 and osteopontin (ETA-1). Science. 271:1996;509-512.
59. West D. C., Hampson I. N., Arnold F. Angiogenesis induced by degradation products of hyaluronic acid. Science. 228:1985;324-326.
60. Wheatley S. C., Isacke C. M., Crossley P. H. Restricted expression of hyaluronan receptor, CD44, during postimplantation mouse embryogenesis suggests key roles in tissue formation and patterning. Development. 119:1993;295-306.
61. Yamashita J., Ogawa M., Yamashita S., Nomura M., Saishoji T., Shin S. Immunoreactive hepatocyte growth factor is a strong and independent predictor of recurrence and survival in human breast cancer. Cancer Res. 54:1994;1630-1633.
62. Yeo T. K., Nagy J. A., Yeo K. T., Dvorak H. F., Toole B. P. Increased hyaluronan at sites of attachment to mesentery by CD44-positive mouse ovarian and breast tumor cells. Am. J. Pathol. 148:1996;1733-1740.
63. Yonemura S., Hirao M., Doi Y., Tahashi N., Kondo T., Tsukita S. Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the yuxta-membrane cytoplasmic do main of CD44, CD43 and ICAM-2. J. Cell Biol. 140:1998;885-895.