Bcl-2 targeted overexpression into the erythroid lineage of transgenic mice delays but does not prevent the apoptosis of erythropoietin-deprived erythroid progenitors

Blood

Volumn 90, Issue 8, 1997, Pages 3050-3056

  Lacronique, V ^b   Varlet, P ^b   Mayeux, P ^b   Porteu, A ^b   Gisselbrecht, S ^b   Kahn, A ^b   Lacombe, C ^a  

^a INSERM   (France)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; ERYTHROPOIETIN; PROTEIN BCL 2;

ANIMAL CELL; ARTICLE; BONE MARROW; BURST FORMING UNIT E; CELL DIFFERENTIATION; COLONY FORMING UNIT E; CONTROLLED STUDY; ERYTHROID CELL; ERYTHROPOIESIS; GENE EXPRESSION; HEMATOPOIETIC STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE;

EID: 0030769518     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v90.8.3050     Document Type: Article

References (30)

1. Koury MJ, Bondurant MC: Erythropoietin retards DNA breakdown and prevents programmed cell death in erythroid progenitor cells. Science 248:378, 1990
2. Yu H, Bauer B, Lipke GK, Phillips RL, Van Zant G: Apoptosis and hematopoiesis in murine fetal liver. Blood 81:373, 1993
3. Boyer S, Bishop T, Rogers O, Noyes A, Frelin L, Hobbs S: Roles of erythropoietin, insulin-like growth factor 1, and unidentified serum factors in promoting maturation of purified murine erythroid colony-forming units. Blood 80:2503, 1992
4. Muta K, Krantz S: Apoptosis of human erythroid colony-forming cells is decreased by stem cell factor and insulin-like growth factor-1 as well as erythropoietin. J Cell Physiol 156:264, 1993
5. Spivak J, Pham T, Isaacs M, Hankins W: Erythropoietin is both a mitogen and a survival factor. Blood 77:1228, 1991
6. Koury MJ: Programmed cell death (apoptosis) in hematopoiesis. Exp Hematol 20:391, 1992
7. Yang E, Korsmeyer SJ: Molecular thanatopsis: A discourse on the Bcl-2 family and cell death. Blood 88:386, 1996
8. Silva M, Grillot D, Benito A, Richard C, Nuñez G, Fernandez-Luna JL: Erythropoietin can promote erythroid progenitor survival by repressing apoptosis through Bcl-XL and Bcl-2. Blood 88:1576, 1996
9. Lacronique V, Lopez S, Miquerol L, Porteu A, Kahn A, Raymondjean M: Identification and functional characterization of an erythroid-specific enhancer in the L-type pyruvate kinase gene. J Biol Chem 270:14989, 1995
10. Chirgwyn JM, Przybuyla AZ, MacDonald RY, Rutter WJ: Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294, 1979
11. McLeod D, Shreeve M, Axelrad A: Improved plasma culture system for production of erythrocytic colonies in vitro. Quantitative assay method for CFU-E. Blood 44:517, 1974
12. Nijhof W, Wierenga PK, Staal GEJ, Jansen G: Changes in activities and isozyme pattern of glycolytic enzymes during erythroid differentiation in vitro. Blood 64:607, 1984
13. Lacronique V, Mignon A, Fabre M, Viollet B, Rouquet N, Molina T, Porteu A, Henrion A, Bouscary D, Varlet P, Joulin V, Kahn A: Bcl-2 protects from lethal hepatic apoptosis induced by an anti-Fas antibody in mice. Nat Med 2:80, 1996
14. McDonnell TJ, Deane N, Platt FM, Nuñez G, Jaeger U, McKearn JP, Korsmeyer J: bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell 57:79, 1989
15. Kirby SL, Cook DN, Walton W, Smithies O: Proliferation of multipotent hematopoietic cells controlled by a truncated erythropoietin receptor transgene. Proc Natl Acad Sci USA 93:9402, 1996
16. Strasser A, Harris AW, Bath ML, Cory S: Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. Nature 348:331, 1990
17. Fairbairn LJ, Cowling GJ, Reipert BM, Dexter TM: Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors. Cell 74:823, 1993
18. Collins MKL, Perkins GR, Rodriguez-Tarduchy G, Nieto MA, Lopez-Rivas A: Growth factors as survival factors: Regulation of apoptosis. Bioessays 16:133, 1994
19. Rodel JE, Link DC: Suppression of apoptosis during cytokine deprivation of 32D cells is not sufficient to induce complete granulocytic differentiation. Blood 87:858, 1996
20. Kelley LL, Koury MJ, Bondurant MC, Koury ST, Sawyer ST, Wickrema A: Survival or death of individual proerythroblasts results from differing erythropoietin sensitivities: A mechanism for controlled rates of erythrocyte production. Blood 82:2340, 1993
21. Nuñez G, London L, Hockenbery D, Alexander M, McKearn JP, Korsmeyer SJ: Disregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hematopoietic cell lines. J Immunol 144:3602, 1990
22. Boise LH, Gonzales-Garcia M, Postema CE, Ding L, Lindsten T, Turka LA, Mao X, Nuñez G, Thompson CB: bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74:597, 1993
23. Wang HG, Miyashita T, Takayama S, Sato T, Torigoe T, Krajewski S, Tanaka S, Hovey L, Troppmair J, Rapp UR, Reed JC: Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase. Oncogene 9:2751, 1994
24. Hockenbery DM, Zutter M, Hickey W, Nahm M, Korsmeyer SJ: BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci USA 88:6961, 1991
25. Otani H, Erdos M, Leonard WJ: Tyrosine kinase(s) regulate apoptosis and bcl-2 expression in a growth factor-dependent cell line. J Biol Chem 268:22733, 1993
26. L. Blood 87:3837, 1996
27. Nuñez G, Clarke M: The bcl-2 family of proteins: Regulators of cell death and survival. Trends Cell Biol 4:399, 1994
28. Park J, Bernstein I, Hockenbery D: Primitive human hematopoietic precursors express Bcl-x but not Bcl-2. Blood 86:868, 1995
29. Motoyama N, Wang F, Roth KA, Sawa H, Nakayama KI, Nakayama K, Negishi I, Senju S, Zhang Q, Fujii S, Loh DY: Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science 267:1506, 1995
30. Veis DJ, Sorenson CM, Shutter JR, Korsmeyer SJ: Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 75:229, 1993