Genetic analysis of growth cone migrations in Caenorhabditis elegans

Journal of Neurobiology

Volumn 44, Issue 2, 2000, Pages 281-288

  Suter, Daniel M ^a   Forscher, Paul ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

Caenorhabditis elegans; Growth cone; Signal transduction; UNC 73

Indexed keywords

CYTOPLASM PROTEIN; GUANOSINE TRIPHOSPHATASE; RAC PROTEIN; RHO FACTOR;

CAENORHABDITIS ELEGANS; CELL MOTILITY; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; GENETIC ANALYSIS; GROWTH CONE; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

ANIMAL; CAENORHABDITIS ELEGANS; CELL MOVEMENT; GROWTH CONES; HELMINTH PROTEINS; MUTATION; NERVE TISSUE PROTEINS; NEURONS; SUPPORT, NON-U.S. GOV'T;

EID: 0033859520     PISSN: 00223034     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4695(200008)44:2<281::AID-NEU16>3.0.CO;2-4     Document Type: Review

References (39)

1. Kalirin, a cytosolic protein with spectrin-like and GDP/GTP exchange factor-like domains that interacts with peptidylglycine alpha-amidating monooxygenase, an integral membrane peptide-processing enzyme
2. Cell and growth cone migrations in C. elegans. II
3. Ankyrins: Adaptors between diverse plasma membrane proteins and cytoplasm
4. The genetics of Caenorhabditis elegans
5. Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance
6. UNC-40, a C. elegans homolog of DCC (deleted in colorectal cancer), is required in motile cells responding to UNC-6 netrin cues
7. Genetic enhancers of sem-5 define components of the gonad-independent guidance mechanism controlling sex myoblast migration in Caenorhabditis elegans hermaphrodites
8. Suppressors of ectopic UNC-5 growth cone steering identify eight genes involved in axon guidance in Caenorhabditis elegans
9. Pioneer axon guidance by UNC-129, a C. elegans TGF-beta
10. The multidomain protein Trio binds the LAR transmembrane protein-tyrosine phosphatase contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains
11. Genes necessary for C. elegans cell and growth cone migrations
12. Hams and egls: Genetic analysis of cell migration in Caenorhabditis elegans
13. Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally
14. The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis of C. elegans
15. Genetics of cell and axon migrations in Caenorhabditis elegans
16. The death domain motif found in Fas (Apo-1) and TNF receptor is present in proteins involved in apoptosis and axonal guidance
17. UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans
18. Duet is a novel serine/threonine kinase with Dbl-Homology (DH) and Pleckstrin-Homology (PH) domains
19. Deleted in Colorectal Cancer (DCC) encodes a netrin receptor
20. Slit is the midline repellent for the robo receptor in Drosophila
21. Growth cones stall and collapse during axon outgrowth in Caenorhabditis elegans
22. Regulatory recruitment of signalling molecules to the cell membrane by pleckstrin-homolgy domains
23. Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors
24. Unc-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans
25. Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons
26. Genes necessary for directed axonal elongation or fasciculation in C. elegans
27. Coupling of ras and rac guanosine triphophatases through the ras exchanger sos
28. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
29. An ankyrin-related gene (unc-44) is necessary for proper axonal guidance in Caenorhabditis elegans
30. SMART: Identification and annotation of domains from signalling and extracellular protein sequences
31. mab-20 encodes Semaphorin-2A and is required to prevent ectopic cell contacts during epidermal morphogenesis in C. elegans
32. UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C elegans
33. Regulation of the UNC-5 netrin receptor initiates the first re-orientation of migrating distal tip cells in C. elegans
34. Neuroglia and pioneer neurons express UNC-6 to provide global and local netrin cues for guiding migrations in C. elegans
35. The structure of the nervous system of the nematode Caenorhabditis elegans
36. Caenorhabditis elegans LET-502 is related to Rho-binding kinases and human myotonic dystrophy kinase and interacts genetically with a homolog of the regulatory subunit of smooth muscle myosin phosphatase to affect cell shape
37. The Caenorhabditis elegans mel-11 myosin phosphatase regulatory subunit affects tissue contraction in the somatic gonad and the embryonic epidermis and genetically interacts with the rac signaling pathway
38. The conserved immunoglobulin superfamily member SAX-3/Robo directs multiple aspects of axon guidance in C. elegans
39. Role of a new rho family member in cell migration and axon guidance in C. elegans