Activity of the Na+/H+ exchanger contributes to cardiac damage following ischaemia and reperfusion

Clinical and Experimental Pharmacology and Physiology

Volumn 27, Issue 9, 2000, Pages 727-733

  Allen, Dg ^a   Xiao, X H ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Ischaemia; Na+ H+ exchanger; NHE1; Preconditioning; Reperfusion

Indexed keywords

2 [2 METHYL 5 METHYLSULFONYL 4 (1 PYRROLYL)BENZOYL]GUANIDINE; 5 (N ETHYL N ISOPROPYL)AMILORIDE; 5 (N ISOBUTYL N METHYL)AMILORIDE; AMILORIDE; CALCIUM ION; CARIPORIDE; HOE 692; PROTON; SODIUM ION; UNCLASSIFIED DRUG;

CONFERENCE PAPER; DRUG EFFECT; DRUG SCREENING; HEART INFARCTION PREVENTION; HEART INJURY; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; HYPERCALCEMIA; IC 50; NONHUMAN; PROTON SODIUM EXCHANGE; SODIUM CALCIUM EXCHANGE;

ANIMALS; HUMANS; ISCHEMIC PRECONDITIONING; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; MYOCARDIAL STUNNING; SODIUM-HYDROGEN ANTIPORTER;

EID: 0033844250     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1681.2000.03329.x     Document Type: Conference Paper

References (73)

1. Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium
2. + exchange
3. The myocardial Na(+)-H(+) exchange: Structure, regulation, and its role in heart disease
4. + exchanger during ischemia and preconditioning in the isolated rat heart
5. Myocardial calcium and magnesium in acute ischemic injury
6. 2+ overload in reperfused ischemic myocardium
7. Mechanisms of acute ischemic contractile failure of the heart: Role of intracellular calcium
8. Mechanism of myocardial 'stunning'
9. Stress proteins and myocardial protection
10. Apoptosis in ischemic and reperfused rat myocardium
11. 2+ activation of contraction as a consequence of reperfusion-induced cellular calcium overload in ferret hearts
12. Role of troponin I proteolysis in the pathogenesis of stunned myocardium
13. 2+-dependent proteolysis?
14. 2+-sensitizing property of xanthine oxidase inhibitors
15. Hydrogen peroxide induced impairment of post-ischemic ventricular function is prevented by the sodium-hydrogen exchange inhibitor HOE642 (cariporide)
16. + exchanger
17. + antiporter
18. + exchangers
19. The regulation of the intracellular pH in cells from vertebrates
20. Regulation of intracellular pH in cardiac muscle
21. The sodium/hydrogen exchange system in cardiac cells: Its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH
22. + exchange in the sheep cardiac Purkinje fibre
23. Alpha 1-adrenergic stimulation of Na-H exchange in cardiac myocytes
24. Alpha 1-adrenoceptor and purinoceptor agonists modulate Na-H antiport in single cardiac cells
25. Endothelin and increased contractility in adult rat ventricular myocytes. Role of intracellular alkalosis induced by activation of the protein kinase C-dependent Na(+)-H(+) exchanger
26. Angiotensin II stimulates sodium-dependent proton extrusion in perfused ferret heart
27. Thrombin activates the sarcolemmal Na(+)-H(+) exchanger. Evidence for a receptor-mediated mechanism involving protein kinase C
28. Stretch-induced alkalinization of feline papillary muscle: An autocrine-paracrine system
29. 1- and β-adrenoreceptors
30. Neurohumoral modulation of intracellular pH in the heart
31. Na(+)-H(+) exchange inhibition protects against mechanical, ultrastructural, and biochemical impairment induced by low concentrations of lysophosphatidylcholine in isolated rat hearts
32. + exchanger in the mammalian myocardium
33. + antiport
34. + antiporter. Analysis of phosphorylation and subcellular localization
35. Amiloride and its analogs as tools in the study of ion transport
36. + exchange inhibitor and its effects in cardiac ischaemia
37. Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion
38. A new sodium/hydrogen exchange inhibitor, EMD 85131, limits infarct size in dogs when administered before or after coronary artery occlusion
39. +-exchange inhibitor Hoe 642 on intracellular pH, calcium and sodium in isolated rat ventricular myocytes
40. Studies of acidosis in the ischaemic heart by phosphorus nuclear magnetic resonance
41. Metabolic changes during ischaemia and their role in contractile failure in isolated ferret hearts
42. 2+ exchange
43. Amiloride delays the ischemia-induced rise in cytosolic free calcium
44. + exchange
45. 87Rb NMR spectroscopic study
46. Sodium channel blockade reduces hypoxic sodium loading and sodium-dependent calcium loading
47. + exchange is not operative under low-flow ischemic conditions
48. + exchanger
49. Changes in myoplasmic pH and calcium concentration during exposure to lactate in isolated rat ventricular myocytes
50. Changes in myoplasmic sodium concentration during exposure to lactate in perfused rat heart
51. Sodium regulation during ischemia versus reperfusion and its role in injury
52. Mechanisms of pH(i) recovery after global ischemia in the perfused heart
53. Mechanism of preconditioning: Ionic alterations
54. + during myocardial ischemia: Consequences for post-ischemic recovery
55. Ischemic preconditioning: Effects on pH, Na and Ca in newborn rabbit hearts during ischemia/reperfusion
56. 2+] during ischemia and reperfusion
57. Rational basis for use of sodium-hydrogen exchange inhibitors in myocardial ischemia
58. Inhibition of sodium-hydrogen exchange reduces infarct size in the isolated rat heart: A protective additive to ischaemic preconditioning
59. Influence of perfusate pH on the postischemic recovery of cardiac contractile function: Involvement of sodium-hydrogen exchange
60. + exchange immediately during reperfusion
61. + exchange and reperfusion arrhythmias: Protection by intracoronary infusion of a novel inhibitor
62. Ischaemic preconditioning: Present position and future directions
63. Protein kinase C: Its role in ischemic preconditioning in the rat
64. Preconditioning of isolated rat heart is mediated by protein kinase C
65. Preconditioning protects ischemic rabbit heart by protein kinase C activation
66. Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs
67. + currents by protein kinase C and adenosine. Implications for ischemic preconditioning
68. Mitochondrial ATP-dependent potassium channels: Novel effectors of cardioprotection?
69. Activation of mitochondrial K(ATP) channel elicits late preconditioning against myocardial infarction via protein kinase C signaling pathway
70. Ischemic pre-conditioning slows energy metabolism and delays ultrastructural damage during a sustained ischemic episode
71. Hypoxia increases persistent sodium current in rat ventricular myocytes
72. Role of Na(+)-H(+) exchange in mediating effects of endothelin-1 on normal and ischemic/reperfused hearts
73. Guard during ischemia against necrosis (GUARDIAN) trial in acute coronary syndromes