The single neurofilament subunit of the lamprey forms filaments and regulates axonal caliber and neuronal size in vivo

Cell Motility and the Cytoskeleton

Volumn 46, Issue 3, 2000, Pages 166-182

  Hall, Garth F ^a   Chu, Boyang ^c   Lee, Sangmook ^a   Liu, Yu ^b   Yao, Jun ^a  

^a University of Massachusetts Lowell   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c NONE

Author keywords

Identified neuron; Microinjection; Microtubule; Neurofilament spacing; Neurofilament transport; Plasmid

Indexed keywords

NEUROFILAMENT PROTEIN; PROTEIN SUBUNIT;

ANIMAL TISSUE; ARTICLE; CELL SIZE; CONTROLLED STUDY; ELECTRON MICROSCOPY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; LAMPREY; MOTOR NEURON DISEASE; NERVE CELL; NERVE FIBER; NERVE FIBER TRANSECTION; NEUROFILAMENT; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

ANIMALS; AXONS; CELL SIZE; CYTOSKELETON; DNA MUTATIONAL ANALYSIS; GENE DELETION; GENE EXPRESSION; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; INDICATORS AND REAGENTS; LAMPREYS; LUMINESCENT PROTEINS; MICE; MICROINJECTIONS; MICROSCOPY, ELECTRON; NEUROBLASTOMA; NEUROFILAMENT PROTEINS; NEURONS; PHOSPHORYLATION; PLASMIDS; PROTEIN STRUCTURE, TERTIARY; TRANSFECTION; TUMOR CELLS, CULTURED;

ANIMALIA; MAMMALIA; PETROMYZONTIDAE; VERTEBRATA;

EID: 0033841994     PISSN: 08861544     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0169(200007)46:3<166::AID-CM2>3.0.CO;2-8     Document Type: Article

References (67)

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11. Neuropathological abnormalities in transgenic mice harbouring a phosphorylation mutant neurofilament transgene
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13. Co-alignment of vimentin intermediate filaments with microtubules depends on kinesin
14. Extensive dendritic sprouting induced by close axotomy of central neurons in the lamprey
15. The pattern of dendritic sprouting and retraction induced by axotomy of lamprey central neurons
16. Sprouts emerging from the dendrites of axotomized lamprey central neurons have axonlike ultrastructure
17. Axotomy-induced neurofilament phosphorylation is inhibited in situ by microinjection of PKA and PKC inhibitors into identified lamprey neurons
18. Neurofilament sidearm proteolysis is a prominent early effect of axotomy in lamprey giant central neurons
19. Microtubule destabilization and neurofilament phosphorylation precede dendritic sprouting after close axotomy of lamprey central neurons
20. Tau overexpressed in identified lamprey neurons in situ is spatially segregated by phosphorylation state, forms hyperphosphorylated, dense aggregations and induces neurodegeneration
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22. The rod domain of NF-L determines neurofilament architecture, whereas the end domains specify filament assembly and network formation
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27. Changes in neurofilament transport coincide temporally with alteration in the caliber of axons in regenerating motor fibers
28. Neurofilament gene expression: A major determinant of axonal caliber
29. The single lamprey neurofilament subunit lacks multiphosphorylation repeats and is expressed selectively in projection neurons
30. Developmental increases in expression of neurofilament mRNA selectively in projection neurons of the lamprey CNS
31. NF subunits can undergo axonal transport without incorporation into insoluble structures
32. Neurofilaments are obligate heteropolymers in vivo
33. Novel monoclonal antibodies provide evidence for the in situ existence of a non phosphorylated form of the largest neurofilament subunit
34. Multiple phosphorylated variants of the high molecular mass subunit of neurofilaments in axons of retinal cell neurons: Characterization and evidence for their differential association with stationary and moving neurofilaments
35. Phosphorylation-dependent neurofilament epitopes are reduced at the node of Ranvier
36. Ultrastructural analysis of early changes following axotomy in giant spinal axons of the lamprey
37. Slow transport rates of cytoskeletal proteins change during regeneration of axotomized retinal neurons in adult rats
38. Dephosphorylation suppresses the activity of neurofilament to promote tubulin polymerization
39. Interaction of the tail domain of high molecular weight subunits of neurofilaments with the COOH-terminal region of tubulin and its regulation by tau protein kinase II
40. Expression of NF-L in both neuronal and nonneuronal cells of transgenic mice: Increased neurofilament density in axons without affecting caliber
41. Two distinct functions of the carboxyl-terminal tail domain of NF-M upon neurofilament assembly: Cross-bridge formation and longitudinal elongation of filaments
42. Neurofilament phosphorylation: A new look at regulation and function
43. Phosphorylation on carboxyl terminus domains of neurofilament proteins in retinal ganglion cell neurons in vivo: Influences on regional neurofilament accumulation, interneurofilament spacing, and axon caliber
44. Axotomy-induced alterations in the synthesis and transport of neurofilaments and microtubules in dorsal root ganglion cells
45. Axotomy-induced changes in the expression of a type III neuronal intermediate filament gene
46. Neurofilament spacing, phosphorylation, and axon diameter in regenerating and uninjured lamprey axons
47. Lamprey neurofilaments combine in one subunit the features of each mammalian NF triplet protein but are highly phosphorylated only in large axons
48. Rapid movement of vimentin on microtubule tracks: Kinesin dependent assembly of intermediate folament networks
49. Neurofilaments are spaced randomly in the radial dimension of axons
50. Internal axonal cytoarchitecture is shaped locally by external compressive forces
51. Reduced diameter and conduction velocity of myelinated fibers in the sciatic nerve of a neurofilament deficient mutant quail
52. Phosphate dependent and independent neurofilament epitopes in the axonal swellings of patients with motoneuron disease and controls
53. The electron microscopy of the lamprey spinal cord
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56. Monoclonal antibodies distinguish phosphorylated and non-phosphorylated forms of neurofilaments in situ
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59. Visualization of slow axonal transport in vivo
60. Changes in cytoskeletal proteins in the rat facial nucleus following axotomy
61. Aluminum intoxication: A disorder of neurofilament transport in motor neurons
62. Physiological and anatomical characteristics of reticulospinal neurones in lamprey
63. Increasing neurofilament subunit NF-M expression reduces axonal NF-H, inhibits radial growth, and results in neurofilamentous accumulation in motor neurons
64. Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease
65. Subunit composition of neurofilaments specifies axonal diameter
66. Kinesin-mediated transport of neurofilament protein oligomers in growing axons