Can the heat shock protein 90 inhibitor geldanamycin be designed to specifically inhibit HER-2 tyrosine kinase?

Drug Resistance Updates

Volumn 3, Issue 4, 2000, Pages 203-205

  Neckers, Leonard M ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GELDANAMYCIN; HEAT SHOCK PROTEIN 90; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE HER 2; UNCLASSIFIED DRUG;

DRUG ACTIVITY; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME STABILITY; PRIORITY JOURNAL; REVIEW; STRUCTURE ANALYSIS;

EID: 0033835021     PISSN: 13687646     EISSN: None     Source Type: Journal    
DOI: 10.1054/drup.2000.0149     Document Type: Article

References (22)

1. Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: Essential role for stress proteins in oncogenic transformation
2. The Hsp90 chaperone family
3. Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90
4. Polyubiquitination and proteasomal degradation of the p185c-erbB2 receptor protein tyrosine kinase induced by geldanamycin
5. Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives
6. The HER-2/neu oncogene in breast cancer: Prognostic factor, predictive factor and target for therapy
7. Therapeutic applications of anti-growth factor receptor antibodies
8. Phase II study of receptorenhanced chemosensitivity using recombinant humanized p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-over-expressing metastatic breast cancer refractory to chemotherapy treatment
9. p185erbB2 binds to Grp94 in vivo
10. Synthesis and evaluation of antiproliferative activity of a geldanamycin-Herceptin immunoconjugate
11. Identification of a geldanamycin dimer that induces the selective degradation of HER-family tyrosine kinases
12. Crystal structure of an Hsp90: Geldanamycin complex - Targeting of a protein chaperone by an anti-tumor agent
13. The amino terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation
14. The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to Hsp90 and shares important biologic activities with geldanamycin
15. Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones
16. The hsp90-related protein TRAPI is a mitochondrial protein with distinct functional properties
17. Ubiquitin ligase activity and tyrosine phosphorylation suppression of growth factor signaling by c-Cbl/Sli-I
18. Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers
19. 14C]herbimycin A and its use in the elucidation of the kinase inactivation mechanism
20. Effects of the tyrosine kinase inhibitor geldanamycin on ligand-induced Her-1/neu activation, receptor expression and proliferation of Her-2-positive malignant cell lines
21. Hsp90 as an anti-cancer target