Deletion of a silencer element disrupts H19 imprinting independently of a DNA methylation epigenetic switch

Development

Volumn 127, Issue 16, 2000, Pages 3419-3428

  Drewell, R A ^a   Brenton, J D ^a   Ainscough, J F X ^a   Barton, S C ^a   Hilton, K J ^a   Arney, K L ^a   Dandolo, L ^a   Surani, M A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

DNA methylation; Epigenetic; Genomic imprinting; H19; Igf2; Silencer

Indexed keywords

CIS ACTING ELEMENT; DNA;

ALLELE; ARTICLE; CONTROLLED STUDY; DNA METHYLATION; DNA REPLICATION; DROSOPHILA; ENDODERM; ENHANCER REGION; EXTRACHROMOSOMAL INHERITANCE; GENE DELETION; GENE EXPRESSION; GENOME IMPRINTING; MOUSE; NONHUMAN; PRIORITY JOURNAL; SILENCER GENE;

ANIMALS; DNA METHYLATION; DNA REPLICATION; FEMALE; GENE DELETION; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; GENOMIC IMPRINTING; INSULIN-LIKE GROWTH FACTOR II; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED CBA; MUSCLE PROTEINS; RNA, UNTRANSLATED;

EID: 0033832962     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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16. Chromatin conformation of the H19 epigenetic mark
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18. Biallelic transcription of Igf2 and H19 in individual cells suggests a post-transcriptional contribution to genomic imprinting
19. Parental allele-specific chromatin configuration in a boundary-imprinting-control element upstream of the mouse H19 gene
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22. An enhancer deletion affects both H19 and Igf2 expression
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34. Asynchronous replication of imprinted genes is established in the gametes and maintained during development
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45. A novel cis-regulatory element, the PTS, mediates an anti-insulator activity in the Drosophila embryo