Recent aspects of gonadal hormone and neurotransmitter interactions with synovial and immune cells: Implications in rheumatoid arthritis

Annals of the Rheumatic Diseases

Volumn 59, Issue 9, 2000, Pages 657-661

  Cutolo, Maurizio ^a   Straub, Rainer H ^b  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY HOSPITAL REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; ESTROGEN; INTERLEUKIN 6; NEUROTRANSMITTER; SEX HORMONE;

ARTICLE; CYTOKINE RELEASE; HYPOPHYSIS GONAD SYSTEM; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; INFLAMMATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVIOCYTE; T LYMPHOCYTE;

ARTHRITIS, RHEUMATOID; AUTOIMMUNE DISEASES; GONADAL STEROID HORMONES; HUMANS; IMMUNITY, CELLULAR; NEUROTRANSMITTER AGENTS; SYNOVIAL MEMBRANE;

EID: 0033832238     PISSN: 00034967     EISSN: None     Source Type: Journal    
DOI: 10.1136/ard.59.9.657     Document Type: Article

References (69)

1. 1 Bijlsma JWJ, Cutolo M, Masi AT, Chikanza I. Neuroendocrine immune basis of the rheumatic diseases. Immunol Today 1999;20:298-301.
2. 2 Masi AT, Bijlsma JWJ, Chikanza IC, Pitzalis C, Cutolo M. Neuroendocrine, immunological, and microvascular systems interactions in rheumatoid arthritis; physiopathogenetic and therapeutic perspectives. Semin Arthritis Rheum 1999;29:65-81.
3. 3 Cutolo M, Prete C, Walker J. Is stress a factor in the pathogenesis in autoimmune rheumatic diseases? Clin Exp Rheumatol 1999;17:515-18.
4. 4 Walker JG, Littlejohn G, McMurray NE, Cutolo M. Stress system activation in rheumatoid arthritis: a multilevel approach. Rheumatology 1999;38; 1050-7.
5. 5 Cutolo M, Castagnetta L. Immunomodulatory mechanisms mediated by sex hormones in rheumatoid arthritis. Ann N Y Acad Sci 1996;784:534-41.
6. 6 Masi AT, da Silva JAP, Cutolo M. Perturbations of the hypothalamic pituitary gonadal axis in rheumatoid arthritis. In: Chikanza IC, ed. Neuroendocrine immune mechanisms of rheumatic diseases. Ballieres Clin Rheumatol 1996;10:295-331.
7. 7 Cutolo M. Do sex hormones modulate synovial macrophages in rheumatoid arthritis? Ann Rheum Dis 1997;56:281-4.
8. 8 Matucci-Cerinic M, Konttinen Y, Generini S, Cutolo M. Neuropeptides and steroid hormones in arthritis. Curr Opin Rheumatol 1998;10:220-35.
9. 9 Cutolo M, Sulli A, Barone A, Seriolo B, Accardo S. Macrophages, synovial tissue and rheumatoid arthritis. Clin Exp Rheumatol 1993;11:331-9.
10. 10 Zvaifler NJ. Macrophages and the synovial lining. Scand J Rheumatol 1995; 24(suppl 101):67-75.
11. 11 Cutolo M, Accardo S, Villaggio B, Barone A, Sulli A, Coviello DA, et al. Androgen and estrogen receptors are present in primary cultures of human synovial macrophages. J Clin Endocrinol Metab 1996;81:820-7.
12. 12 Burmester GR, Stuhlmuller B, Keyszer G, Kinne RW. Mononuclear phagocytes and rheumatoid synovitis. Arthritis Rheum 1997;40:5-18.
13. 13 Van Lent PELM, Holthuysen AEM, Van der Berselaar L, Van Rooijen N, Van de Putte LBA, Van der Berg WB. Role of macrophage-like synovial lining cells in localization and expression of experimental arthritis. Scand J Rheumatol 1995;24(suppl 101):83-9.
14. 14 Mulherim D, Fitzgerald O, Bredniham B. Synovial tissue macrophage populations and articular damage in rheumatoid arthritis. Arthritis Rheum 1996;39:115-24.
15. 15 Cutolo M. Macrophages as effectors of the immunoendocrinologic interactions in autoimmune rheumatic diseases. Ann N Y Acad Sci 1999;876:32-43.
16. 16 Wilder RL. Neuroendocrine-immune system interactions and autoimmunity. Annu Rev Immunol 1995;13:307-38.
17. 17 Cutolo M. The role of the hypothalamus-pituitary-adrenocortical and -gonadal axis in rheumatoid arthritis. Clin Exp Rheumatol 1998;16:3-6.
18. 18 Chrousos GP. The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Med 1995;332:1351-62.
19. 19 De LaTorre B, Hedman M, Olesen E, Thorner A. Relationship between blood and joint tissue DHEAS levels in rheumatoid arthritis and osteoarthritis. Clin Exp Rheumatol 1993;11:597-601.
20. 20 Cutolo M, Masi AT. Do androgens influence the pathophysiology of rheumatoid arthritis? Ann Rheum Dis 1997;56:281-4.
21. 21 Straub RH, Zeuner M, Antiniou E, Schölmerich J, Lang B. Dehydroepiandrosterone sulfate is positively correlated with soluble interleukin 2 receptor and soluble intercellular adhesion molecule in systemic lupus erythematosus. J Rheumatol 1996;23:856-61.
22. 22 Straub RH, Zeuner M, Lock G, Schölmerich J, Lang B. High prolactin and low dehydroepiandrosterone sulfate serum levels in patients with severe systemic sclerosis. Br J Rheumatol 1997;36:426-32.
23. 23 Cutolo M, Accardo S, Villaggio B, Barone A, Sulli A, Balleari E, et al. Androgen metabolism and inhibition of interleukin-1 synthesis in primary cultures of human synovial macrophages. Mediators of Inflammation 1995;4:138-43.
24. 24 Kanda N, Tsuchida T, Tamaki K. Testosterone inhibits immunoglobulin production by human peripheral blood mononuclear cells. Clin Exp Immunol 1996;106:410-19.
25. 25 Polan ML, Loukides J, Nelson P, Carding S, Diamond M, Walsh A, et al. Progesterone and estradiol modulate interleukin-1β messenger ribonucleic acid levels in cultured human peripheral monocytes. J Clin Endocrinol Metab 1989;69:1200-6.
26. 26 Da Silva JAP, Pinto A, Cutolo M, Porto A. Gender differences in adrenal and gonadal responses in inflammatory aggression. Ann N Y Acad Sci 1999;876:148-51.
27. 27 Cutolo M. Do sex hormones modulate synovial macrophages in rheumatoid arthritis? Facts and hypotheses. J Rheumatol 1998;25:1041-7.
28. 28 Castagnetta L, Cutolo M, Granata O, Di Falco M, Bellavia V, Carruba G. Endocrine end-points in rheumatoid arthritis. Ann N Y Acad Sci 1999;876:180-92.
29. 29 Nestler JE. Interleukin-1 stimulates aromatase activity of human placental cytotrophoblasts. Endocrinology 1993;132:566-70.
30. 30 Macdiarmid F, Wang D, Duncan LG, Purohit A, Ghilchick MW, Reed MJ. Stimulation of aromatase activity in breast fibroblasts by tumor necrosis factor α. Mol Cell Endocrinol 1994;106:17-21.
31. 31 Purohit A, Ghilchick MW, Duncan L, Wang DY, Singh A, Walker MM, et al. Aromatase activity and interleukin-6 production by normal and malignant breast tissues. J Clin Endocrinol Metab 1995;80:3052-8.
32. 32 Speirs V, Adams EF, White MC. The anti-estrogen tamoxifen blocks the stimulatory effects of interleukin-6 on 17β-hydroxysteroid dehydrogenase activity in MCF-7 cells. J Steroid Biochem Molec Biol 1993;46:605-11.
33. 33 Suenaga R, Evans ME, Mitamura KO, Rider V, Abdou NI. Peripheral blood T cells and monocytes and B cell lines derived from patients with systemic lupus erythematosus express estrogen receptor transcripts similar to those of normal cells. J Rheumatol 1998;25:1305-10.
34. 34 Sthoeger ZM, Chiorazzi N, Lahita RG. Regulation of the immune response by sex hormones. In vitro effects of estradiol and testosterone on pokeweed mitogen-induced human B cell differentiation. J Immunol 1988; 141:91-9.
35. 35 Kanda N, Tamaki K. Estrogen enhances immunoglobulin production by human PBMCs. J Allergy Clin Immunol 1999;103:282-9.
36. 36 Kanda N, Tsuchida T, Tamaki K. Estrogen enhancement of anti-double-stranded DNA antibody and immunoglobulin G production in peripheral blood mononuclear cells from patients with systemic lupus erythematosus. Arthritis Rheum 1999;42:328-35.
37. 37 Kanda N, Tuschida T, Tamaki K. Testosterone suppresses anti-DNA antibody production in peripheral blood mononuclear cells from patients with systemic lupus erythematosus. Arthritis Rheum 1997;40:1703-9.
38. 38 Cutolo M, Accardo S, Villaggio B, Clerico P, Bagnasco M, Coviello D, et al. Presence of estrogen binding sites in macrophage-like synoviocytes and CD8+CD29+ CD45RO+ T lymphocytes in normal and rheumatoid synovia. Arthritis Rheum 1993;36:1087-95.
39. 39 Ushiyama T, Inoue K, Nishioka J. Expression of estrogen receptor related protein (p29) and estradiol binding in human arthritis synovia. J Rheumatol 1995;22:421-9.
40. 40 Araneo BA, Dowell T, Diegel M, Daynes RA. Dihydrotestosterone exerts a depressive influence on the production of interleukin-4 (IL-4), IL-5, and IFNγ, but not IL-2 by activated murine T cells. Bood 1991;78:688-705.
41. 41 Dalal M, Kim S, Voskuhl R. Testosterone ameliorates experimental autoimmune encephalomyelitis and induces a T helper 2 bias in autoantigen-specific T lymphocyte response. J Immunol 1997;159:3-15.
42. 42 Goldie I, Wellisch M. The presence of nerves in original and regenerated synovial tissue in patients synovectomised for rheumatoid arthritis. Acta Orthop Scand 1969;40:143-52.
43. 43 Dick WC, Porter B, Whaley K, Nuki G, Downie WW, Buchanan WW. Sympathetic control of synovial blood vessels. Ann Rheum Dis 1970; 29:691-9.
44. 44 Sneddon P. Co-transmission. In: Powis DA, Bunn SJ, eds. Neurotransmitter release and its modulation. Cambridge: Cambridge University Press, 1995:22-37.
45. 45 Riches DW, Watkins JL, Henson PM, Stanworth DR. Regulation of macrophage lysosomal secretion by adenosine, adenosine phosphate esters, and related structural analogues of adenosine. J Leukoc Biol 1985; 37:545-57.
46. 46 Gronblad M, Korkala O, Liesi P, Karaharju E. Innervation of synovial membrane and meniscus. Acta Orthop Scand 1985;56:484-6.
47. 47 Abramovici A, Daizade I, Yosipovitch Z, Gibson SJ, Polak JM. The distribution of peptide-containing nerves in the synovia of the cat knee joint. Histol Histopathol 1991;6:469-76.
48. 48 Lotz M, Vaughan JH, Carson DA. Effect of neuropeptides on production of inflammatory cytokines by human monocytes. Science 1988;241:1218-21.
49. 49 Calvo CF, Chavanel G, Senik A. Substance P enhances IL-2 expression in activated human T cells. J Immunol 1992;148:3498-504.
50. 50 Serra MC, Calzetti F, Ceska M, Cassatella MA. Effect of substance P on superoxide anion and IL-8 production by human PMNL. Immunology 1994;82:63-9.
51. 51 Lieb K, Fiebich BL, Berger M, Bauer J, Schulze-Osthoff K. The neuropeptide substance P activates transcription factor NF-kappa B and kappa B-dependent gene expression in human astrocytoma cells. J Immunol 1997;159:4952-8.
52. 52 Tanabe T, Otani H, Mishima K, Ogawa R, Inagaki C. Mechanisms of oxyradical production in substance P stimulated rheumatoid synovial cells. Rheumatol Int 1996;16:159-67.
53. 53 Levine JD, Clark R, Devor M, Helms C, Moskowitz MA, Basbaum AI. Intraneuronal substance P contributes to the severity of experimental arthritis. Science 1984;226:547-9.
54. 54 Lam FY, Ferrell WR. Inhibition of carrageenan induced inflammation in the rat knee joint by substance P antagonist. Ann Rheum Dis 1989; 48:928-32.
55. 55 Wiedermann CJ, Wiedermann FJ, Apperl A, Kieselbach G, Konwalinka G, Braunsteiner H. In vitro human polymorphonuclear leukocyte chemokinesis and human monocyte chemotaxis are different activities of aminoterminal and carboxyterminal substance P. Naunyn Schmiedebergs Arch Pharmacol 1989;340:185-90.
56. 56 Heppelmann B, Pawlak M. Sensitisation of articular afferents in normal and inflamed knee joints by substance P in the rat. Neurosci Lett 1997;223:97-100.
57. 57 Watling KJ. The RBI handbook of receptor classification and signal transduction. 3rd ed. Natick: RBI, 1998.
58. 58 Renz H, Gong JH, Schmidt A, Nain M, Gemsa D. Release of tumor necrosis factor-alpha from macrophages. Enhancement and suppression are dose-dependently regulated by prostaglandin E2 and cyclic nucleotides. J Immunol 1988;141:2388-93.
59. 59 Spengler RN, Chensue SW, Giacherio DA, Blenk N, Kunkel SL. Endogenous norepinephrine regulates tumor necrosis factor-alpha production from macrophages in vitro. J Immunol 1994;152:3024-31.
60. 60 Elenkov IJ, Papanicolaou DA, Wilder RL, Chrousos GP. Modulatory effects of glucocorticoids and catecholamines on human interleukin-12 and interleukin-10 production: clinical implications. Proc Assoc Am Physicians 1996;108:374-81.
61. 61 Sanders VM, Baker RA, Ramer-Quinn DS, Kasprowicz DJ, Fuchs BA, Street NE. Differential expression of the beta2-adrenergic receptor by Th1 and Th2 clones: implications for cytokine production and B cell help. J Immunol 1997;158:4200-10.
62. 62 Spengler RN, Allen RM, Remick DG, Strieter RM, Kunkel SL. Stimulation of alpha-adrenergic receptor augments the production of macrophage-derived tumor necrosis factor. J Immunol 1990;145:1430-4.
63. 63 Miller LE, Wessinghage D, Jüsten H-P, Schölmerich J, Straub RH. The loss of sympathetic nerve fibers in the synovial membrane of patients with rheumatoid arthritis is accompanied by increased norepinephrine release from synovial macrophages. FASEB J (in press).
64. 64 DiBattista JA, Martel-Pelletier J, Cloutier JM, Pelletier JP. Modulation of glucocorticoid receptor expression in human articular chondrocytes by cAMP and prostaglandins. J Rheumatol Suppl 1991;27:102-5.
65. 65 Cotecchia S, De Blasi A. Glucocorticoids increase beta-adrenoceptors on human intact lymphocytes in vitro. Life Sci 1984;35:2359-64.
66. 66 Cutolo M. Sex hormone adjuvating therapy in rheumatoid arthritis. Rheum Dis Clin North Am (in press).
67. 67 Straub RH, Glück T, Cutolo M, Georgi J, Helme K, Shölmerich J, et al. The adrenal steroid status in relation to inflammatory cytokines IL-6 and TNF in polymyalgia rheumatica. Rheumatogy (in press).
68. 68 Cutolo M, Villaggio B, Sulli A, Seriolo B, Giusti M. CYP17 gene polymorphisms and androgen levels in postmenopausal patients with rheumatoid arthritis. Clin Exp Rheumatol 2000;18:420-1.
69. 69 Schmidt M, Kreutz M, Löffler G, Schölmerich G, Straub RH. Conversion of dehydroepiandrosterone to downstream steroid hormones in macrophages. J Endocrinol 2000;164:161-9.