Mutational definition of functional domains within the Rev homolog encoded by human endogenous retrovirus K

Journal of Virology

Volumn 74, Issue 20, 2000, Pages 9353-9361

  Bogerd, H P ^a   Wlegand, H L ^a   Yang, J ^a   Cullen, B R ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MUTANT PROTEIN; NUCLEAR RNA; PROTEIN INHIBITOR; REV PROTEIN; VIRUS PROTEIN; VIRUS RNA;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; GENE INACTIVATION; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN RNA BINDING; RETROVIRUS; RNA SPLICING; RNA TRANSPORT; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; CARRIER PROTEINS; ENDOGENOUS RETROVIRUSES; GENE PRODUCTS, REV; HIV-1; HUMAN; MOLECULAR SEQUENCE DATA; MUTATION; PHENOTYPE; RNA;

EID: 0033819512     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.20.9353-9361.2000     Document Type: Article

References (45)

1. Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans
2. Recruitment of a protein complex containing Tat and cyclin T1 to TAR governs the species specificity of HIV-1 Tat
3. Inhibition of human immunodeficiency virus Rev and human T-cell leukemia virus Rex function, but not Mason-Pfizer monkey virus constitutive transport element activity, by a mutant human nucleoporin targeted to Crm1
4. Protein sequence requirements for function of the human T-cell leukemia virus type 1 Rex nuclear export signal delineated by a novel in vivo randomization-selection assay
5. Genetic evidence that the Tat proteins of human immunodeficiency virus types 1 and 2 can multimerize in the eukaryotic cell nucleus
6. Dominant negative mutants of human T-cell leukemia virus type 1 Rex and human immunodeficiency virus type 1 Rev fail to multimerize in vivo
7. Transdominant repressors for human T-cell leukemia virus type 1 Rex and human immunodeficiency virus type 1 Rev function
8. Retroviruses as model systems for the study of nuclear RNA export pathways
9. A novel genetic system to detect protein-protein interactions
10. The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs
11. CRM1 is an export receptor for leucine-rich nuclear export signals
12. The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88
13. A nuclear role for the fragile X mental retardation
14. Nuclear export of late HIV-1 mRNAs occurs via a cellular protein export pathway
15. Amphibian transcription factor IIIA proteins contain a sequence element functionally equivalent to the nuclear export signal of human immunodeficiency virus type 1
16. In vitro binding of human T-cell leukemia virus Rex proteins to the Rex-response element of viral transcripts
17. A novel exogenous retrovirus sequence identified in humans
18. Involvement of human CRM1 (exportin 1) in the export and multimerization of the Rex protein of human T-cell leukemia virus type I
19. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclindependent kinases
20. Titration of cellular export factors, but not heteromultimerization, is the molecular mechanism of trans-dominant HTLV-1 Rex mutants
21. Post-transcriptional regulator (Rex) of HTLV-1 initiates expression of viral structural proteins but suppresses expression of regulatory proteins
22. Effector domains of human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex are functionally interchangeable and share an essential peptide motif
23. Steroid-receptor fusion of the human immunodeficiency virus type 1 Rev transactivator: Mapping cryptic functions of the arginine-rich motif
24. The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences
25. Characterization of the nuclear export signal of human T-cell lymphotropic virus type 1 Rex reveals that nuclear export is mediated by position-variable hydrophobic interactions
26. Sequence requirements for Rev multimerization in vivo
27. cORF and RcRE, the Rev/Rex and RRE/RxRE homologues of the human endogenous retrovirus family HTDV/HERV-K
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29. The HIV-1 Rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA
30. Mutational definition of the human immunodeficiency virus type 1 Rev activation domain
31. The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export
32. PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation
33. Importin β can mediate the nuclear import of an arginine-rich nuclear localization signal in the absence of importin α
34. The HIV-1 Rev protein
35. Trans-dominant inactivation of HTLV-I and HIV-1 gene expression by mutation of the HTLV-1 Rex transactivator
36. A three-hybrid system to detect RNA-protein interactions in vivo
37. The HIV-1 Tat protein activates transcription from an upstream DNA-binding site: Implications for Tat function
38. Exportin 1 (Crm1p) is an essential nuclear export factor
39. Identification and characterization of novel human endogenous retrovirus families by phylogenetic screening of the human genome mapping project database
40. The arginine-rich domains present in human immunodeficiency virus type I Tat and Rev function as direct importin β-dependent nuclear localization signals
41. Definition of the human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex protein activation domain by functional exchange
42. Identification of a signal for rapid export of proteins from the nucleus
43. An ancient family of human endogenous retroviruses encodes a functional homolog of the HIV-1 Rev protein
44. Oligomerization and RNA binding domains of the type I human immunodeficiency virus Rev protein: A dual function for an arginine-rich binding motif