Genotypes with the apolipoprotein ε4 allele are predictors of coronary heart disease mortality in a longitudinal study of elderly Finnish men

Human Genetics

Volumn 97, Issue 5, 1996, Pages 677-684

  Stengård, Jari H ^a,b   Pekkanen, Juha ^a   Ehnholm, Christian ^a   Nissinen, Aulikki ^c   Sing, Charles F ^b  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E4; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; APOLIPOPROTEIN E;

AGED; ALLELE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DEATH; ENVIRONMENTAL EXPOSURE; FINLAND; GENOTYPE; HUMAN; HUMAN CELL; ISCHEMIC HEART DISEASE; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; RISK; SMOKING; STATISTICAL ANALYSIS; AGE; BLOOD; BLOOD PRESSURE; BODY MASS; COHORT ANALYSIS; COMPARATIVE STUDY; CORONARY ARTERY DISEASE; DEMOGRAPHY; GENETICS; GEOGRAPHY; PATHOPHYSIOLOGY; PROGNOSIS; REPRODUCIBILITY;

AGE FACTORS; AGED; AGED, 80 AND OVER; ALLELES; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; BLOOD PRESSURE; BODY MASS INDEX; CHOLESTEROL; COHORT STUDIES; CORONARY DISEASE; DEMOGRAPHY; FINLAND; GENOTYPE; GEOGRAPHY; HUMANS; LONGITUDINAL STUDIES; MALE; PROGNOSIS; REPRODUCIBILITY OF RESULTS; SMOKING;

EID: 85047680650     PISSN: 03406717     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02281882     Document Type: Article

References (46)

1. Andrade M. Thandi I. Brown S. Gotto A Jr. Patsch W. Boerwinkle E (1995) Relationship of the apolipoprotein E polymorphism with carotid artery atherosclerosis. Am J Hum Genet 56: 1379-1390
2. Assmann G, Schulte H (1989) Diabetes mellitus and hypertension in the elderly: concomitant hyperlipidemia and coronary heart disease risk. Am J Cardiol 63 : 33H-37H
3. Badimon JJ, Fuster V, Chesebro JH, Badimon L (1993) Coronary atherosclerosis: a multifactorial disease. Circulation 87 [Suppl 2] : 3-16
4. Barrett-Connor E, Suarez L, Khaw K-T, Criqui MH, Wingard DL (1984) Ischemic heart disease risk factors after age 50. J Chronic Dis 37 : 903-908
5. Cooper R, Rotimi C (1994) Hypertension in populations of West African origin: is there a genetic predisposition? J Hypertens 12 : 215-227
6. Dawber TR (1980) The Framingham study. Harvard University Press. Cambridge
7. Davignon J (1993) Apolipoprotein E polymorphism and atherosclerosis. In: Born GVR, Schwartz CJ (eds) New horizons in coronary heart disease. Science Press, London, pp 5.1-5.21
8. Davignon J. Gregg RE, Sing CF (1988) Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis 8 : 1-21
9. Davignon J, Roederer G, Trudeau P, Dallongeville J, Sing CF (1989) Atherogenic dyslipidemias: disorders of apolipoprotein E isoforms. In: Crepaldi G, Gotto AM, Manzato E, Gaggio G, (eds) Atherosclerosis VIII. Elsevier, Amsterdam, pp 389-393
10. Ehnholm C, Lukka M, Kuusi T, Nikkilä E, Utermann G (1986) Apolipoprotein E polymorphism in the Finnish population: gene frequencies and relation to lipoprotein concentrations. J Lipid Res 27 : 227-235
11. Ferrannini E (1991) Metabolic abnormalities of hypertension: a lesson in complexity of hypertension 18 : 636-639
12. Ferrières J, Sing CF, Roy M, Davignon J. Lussier-Cacan S (1994) Apolipoprotein E polymorphism and heterozygous familial hypercholesterolemia: sex-specific effects. Arterioscler Thromb 14 : 1553-1560
13. Gerdes LU, Klausen IC. Sihm I. Faergeman O (1992) Apolipoprotein E polymorphism in a Danish population compared to findings in 45 other study populations around the world. Genet Epidemiol 9 : 155-167
14. Gordon T, Kannel WB (1982) Multiple risk functions for predicting coronary heart disease: the concept, accuracy, and application. Am Heart J 103 : 1031-1039
15. Harris T, Cook EF, Kannel WB, Goldman L (1988) Proportional hazards analysis of risk factors for coronary heart disease in individuals aged 65 or older. J Am Geriatr Soc 36 : 1023-1028
16. Havekes LM, et al (1987) A rapid micromethod for apolipoprotein E phenotyping directly in serum. J Lipid Res 28 : 455-463
17. Haviland MB, Lussier-Cacan S, Davignon J, Sing CF (1995) Impact of apolipoprotein E genotype variation on means, variances and correlations of plasma lipid, lipoprotein and apolipoprotein traits in octogenarians. Am J Med Genet 58 : 315-331
18. Heliövaara M, Karvonen MJ, Punsar S, Rautanen Y, Haapakoski J (1981) Serum thiocyanate concentration and cigarette smoking in relation to overall mortality and to deaths from coronary heart disease and lung cancer. J Chronic Dis 34 : 305-311
19. Hosmer DW, Lemeshow S (1989) Applied logistic regression. Wiley, Toronto
20. Jacobsen SJ, et al (1992) Cholesterol and coronary artery disease: age as an effect modifier. J Clin Epidemiol 45 : 1053-1059
21. Kahn HA (1983) An introduction to epidemiologic methods. Oxford University Press, New York
22. Kaprio J, Ferrell RE, Kottke BA, Kamboh MI, Sing CF (1991) Effects of polymorphisms in apolipoproteins E, A-IV, and H on quantitative traits related to risk for cardiovascular disease. Arterioscler Thromb 11 : 1330-1348
23. Karvonen MJ, et al (1970) VI. Five-year experience in Finland. Circulation 41/42 [Suppl 1] : I-52-I-62
24. Keys A (1970) Coronary heart disease in seven countries. Circulation 41 : 1-211
25. Keys A, et al (1967) Epidemiological studies related to coronary heart disease: characteristics of men aged 40-59 in seven countries. Acta Med Scand 460 [Suppl] : 1-392
26. Kostner GM (1976) Enzymatic determination of cholesterol in HDL fractions prepared by polyanion precipitation. Clin Chem 22 : 695
27. Kuusi T, et al (1989) Apoprotein E polymorphism and coronary artery disease: increased prevalence of apolipoprotein E-4 in angiographically verified coronary patients. Arteriosclerosis 9: 237-241
28. Lehtimäki T, et al (1990) Apolipoprotein E phenotypes in Finnish youths: a cross-sectional and 6-year follow-up study. J Lipid Res 31 : 487-495
29. Lewontin RC (1974) The genetic basis of evolutionary change. Columbia University Press. New York
30. Mänttäri M, Koskinen P, Ehnholm C, Huttunen JK, Manninen V (1991) Apolipoprotein E polymorphism influences the serum cholesterol response to dietary intervention. Metabolism 40 : 217-221
31. Nestruck AC, Bouthillier D, Sing CF, Davignon J (1987) Apolipoprotein E polymorphism and plasma cholesterol response to probucol . Metabolism 36 : 743-747
32. Nieminen MS, et al (1992) Lipoproteins and their genetic variation in subjects with and without angiographically verified coronary artery disease. Arterioscler Thromb 12 : 58-69
33. Nissinen A, et al (1986) Levels of some biological risk indicators among elderly men in Finland. Age Aging 15 : 203-211
34. Nissinen A, et al (1993) Prevalence and change of cardiovascular risk factors among men born 1900-1919: the Finnish cohorts of the Seven Countries Study. Age Ageing 22 : 365-376
35. Pekkanen J (1987) Coronary heart disease during a 25-year followup: risk factors and their secular trends in the Finnish cohorts of the Seven Countries Study. Thesis, University of Helsinki
36. Reilly SL, Ferrell RE, Kottke BA, Kamboh MI. Sing CF (1991) The gender-specific apolipoprotein E genotype influence on the distribution of lipids and apolipoproteins in the population of Rochester, MN. I. Pleiotropic effects on means and variances. Am J Hum Genet 49 : 1155-1166
37. Reiuy SL, Ferrell RE, Sing CF (1994) The gender-specific apolipoprotein E genotype influence on the distribution of plasma lipids and apolipoproteins in the population of Rochester, MN. III. Correlations and covariances. Am J Hum Genet 55 : 1001-1018
38. SAS Institute (1985) SAS user's guide: statistics. SAS Institute, Cary, NC
39. Sins CF, Moll PP (1989) Genetics of variability of CHD risk. Int J Epidemiol 18 [Suppl 1] : S183-S195
40. Sing CF, Zerba KE, Reilly SL (1994) Traversing the biological complexity in the hierarchy between genome and CAD end-points in the population at large. Clin Genet 46 : 6-14
41. Stavenow L, et al (1990) Eighty-year-old men without cardiovascular disease in the community of Malmö. I. Social and medical factors, with special reference to the lipoprotein pattern. J Intern Med 228 : 9-15
42. Stengård JH, et al (1995) Apolipoprotein E polymorphism predicts death from coronary heart disease in a longitudinal study of elderly Finnish men. Circulation 91 : 265-269
43. Wahlsten D (1990) Insensitivity of the analysis of variance to heredity-environment interaction. Behav Brain Sci 13 : 109-161
44. Weiss KM (1993) Genetic variation and human disease: principles and evolutionary approaches. Cambridge University Press. Cambridge, UK
45. Wilson PWF, et al (1994) Apolipoprotein E alleles, dyslipidemia, and coronary heart disease: the Framingham offspring study. JAMA 272 : 1666-1671
46. Xhignesse M, Lussier-Cacan S, Sing CF, Kessling AM, Davignon J (1991) Influences of common variants of apolipoprotein E on measures of lipid metabolism in a sample selected for health. Arterioscler Thromb 11 : 1100-1110