The -491A/T apolipoprotein E promoter polymorphism association with Alzheimer's disease: Independent risk and linkage disequilibrium with the known APOE polymorphism

Neuroscience Letters

Volumn 252, Issue 2, 1998, Pages 95-98

  Town, Terrence ^a   Paris, Daniel ^a   Fallin, Danielle ^a   Duara, Ranjan ^b   Barker, William ^b   Gold, Michael ^c   Crawford, Fiona ^a   Mullan, Michael ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

491A T polymorphism; Alzheimer's disease; Apolipoprotein E; Genetic association; Independent risk; Linkage disequilibrium

Indexed keywords

APOLIPOPROTEIN E;

AGED; ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION;

AGED; ALLELES; ALZHEIMER DISEASE; APOLIPOPROTEINS E; FEMALE; GENE FREQUENCY; HAPLOTYPES; HUMANS; LINKAGE (GENETICS); LOGISTIC MODELS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); RISK FACTORS;

EID: 0032563366     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)00567-9     Document Type: Article

References (13)

1. Bullido M.J., Artiga M.J., Recuero M., Sastre I., Garcia M.A., Aldudo J., Lendon C., Han S.W., Morris J.C., Frank A., Vazquez J., Goate A., Valdivieso F. A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia. Nature Genet. 18:1998;69-71.
2. Lambert J.C., Perez-Tur J., Dupire M.J., Galasko D., Mann D., Amouyel P., Hardy J., Delacourte A., Chartier-Harlin M.C. Distortion of allelic expression of apolipoprotein E in Alzheimer's disease. Hum. Mol. Genet. 6:1997;2151-2154.
3. Poirier J., Davignon J., Bouthillier D., Kogan S., Bertrand P., Gauthier S. Apolipoprotein E Polymorphism and Alzheimer's Disease. Lancet. 342:1993;697-699.
4. Poirier J. Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease. Trends Neurosci. 17:1994;525-530.
5. Poirier J., Delisle M.C., Quirion R., Aubert I., Farlow M., Lahiri D., Hui S., Bertrand P., Nalbantoglu J., Gilfix B.M. Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer's disease. Proc. Natl. Acad. Sci. USA. 92:1995;12260-12264.
6. Rebeck G.W., Reiter J.S., Strickland D.K., Hyman B.T. Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions. Neuron. 11:1993;575-580.
7. Saunders A.M., Schmader K., Breitner J.C., Benson M.D., Brown W.T., Goldfarb L., Goldgaber D., Manwaring M.G., Szymanski M.H., McCown N. Apolipoprotein E E4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases. Lancet. 342:1993;710-711.
8. Strittmatter W.J., Saunders A.M., Schmechel D., Pericak-Vance M., Enghild J., Salvesen G.S., Roses A.D. Apolipoprotein E: high activity binding to B-amyloid and to increased frequency of type 4 allele in late-onset familial Alzheimer's disease. Proc. Natl. Acad. Sci. USA. 90:1993;1977-1981.
9. Strittmatter W.J., Saunders A.M., Goedert M., Weisgraber K.H., Dong L.M., Jakes R., Huang D.Y., Pericak-Vance M., Schmechel D., Roses A.D. Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer's disease. Proc. Natl. Acad. Sci. USA. 91:1994;11183-11186.
10. Terwilliger, J. and Ott, J., Handbook of Human Genetic Linkage, Johns Hopkins University Press, Baltimore, 1994.
11. Whenham P.R., Price W.H., Blundell G. Apolipoprotein E genotyping by one-stage PCR. Lancet. 337:1991;1158-1159.
12. Brzustowicz L.M., Merette C., Xie X., Townsend L., Gilliam T.C., Ott J. Molecular and statistical approaches to the detection and correction of errors in genotype databases. Am. J. Hum. Genet. 53:1993;1137-1145.
13. Zhou Z., Smith J.D., Greengard P., Gandy S. Alzheimer amyloid-(peptide forms denaturant-resistant complex with type ε3 but not type ε4 isoform of native apolipoprotein E. Mol. Med. 2:1996;175-180.