Immunization of healthy adults with a single recombinant pneumococcal surface protein A (PspA) variant stimulates broadly cross-reactive antibodies to heterologous PspA molecules

Vaccine

Volumn 18, Issue 17, 2000, Pages 1743-1754

  Nabors, Gary S ^a   Braun, Patricia A ^a   Herrmann, Diane J ^a   Heise, Martha L ^a   Pyle, Derek J ^a   Gravenstein, Stefan ^b   Schilling, Margot ^b   Ferguson, Laura M ^a   Hollingshead, Susan K ^c   Briles, David E ^c   Becker, Robert S ^a  

^a SANOFI PASTEUR   (France)

^b EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Pneumococcus; PspA; Streptococcus

Indexed keywords

BACTERIAL PROTEIN; CROSS REACTING ANTIBODY; EPITOPE; PNEUMOCOCCUS SURFACE PROTEIN A; PNEUMOCOCCUS VACCINE; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ADULT; ANTIBODY RESPONSE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNIZATION; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; STREPTOCOCCUS INFECTION; STREPTOCOCCUS PNEUMONIAE;

ADOLESCENT; ADULT; ANIMALS; ANTIBODIES, BACTERIAL; ANTIBODY FORMATION; ANTIBODY SPECIFICITY; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BINDING, COMPETITIVE; CROSS REACTIONS; DOUBLE-BLIND METHOD; HUMANS; IMMUNOGLOBULIN G; INJECTIONS, INTRAMUSCULAR; MIDDLE AGED; RABBITS; RECOMBINANT PROTEINS; STREPTOCOCCUS PNEUMONIAE; VACCINES, SYNTHETIC;

EID: 0034002412     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(99)00530-7     Document Type: Article

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