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Volumn 15, Issue 11, 1999, Pages 1059-1078

Hansenula polymorpha Pex1p and Pex6p are peroxisome-associated AAA proteins that functionally and physically interact

Author keywords

AAA protein family; Methylotrophic yeast; Microbody; Peroxisome biogenesis; PEX gene

Indexed keywords

ADENOSINE TRIPHOSPHATASE; FUNGAL PROTEIN; MATRIX PROTEIN; MEMBRANE PROTEIN;

EID: 0032789622     PISSN: 0749503X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0061(199908)15:11<1059::AID-YEA434>3.0.CO;2-I     Document Type: Article
Times cited : (71)

References (49)
  • 3
    • 0030659441 scopus 로고    scopus 로고
    • Deviant Pex3p levels affect normal peroxisome formation in Hansenula polymorpha: High steady state levels of the protein fully abolish matrix protein import
    • Baerends, R. J. S., Salomons, F. A., Faber, K. N., Kiel, J. A. K. W., van der Klei, I. J. and Veenhuis, M. (1997a). Deviant Pex3p levels affect normal peroxisome formation in Hansenula polymorpha: high steady state levels of the protein fully abolish matrix protein import. Yeast 13, 1437-1448.
    • (1997) Yeast , vol.13 , pp. 1437-1448
    • Baerends, R.J.S.1    Salomons, F.A.2    Faber, K.N.3    Kiel, J.A.K.W.4    Van Der Klei, I.J.5    Veenhuis, M.6
  • 4
    • 0030656970 scopus 로고    scopus 로고
    • Deviant Pex3p levels affect normal peroxisome formation in Hansenula polymorpha: A sharp increase of the protein level induces the proliferation of numerous, small protein-import competent peroxisomes
    • Baerends, R. J. S., Salomons, F. A., Kiel, J. A. K. W., van der Klei, I. J. and Veenhuis, M. (1997b). Deviant Pex3p levels affect normal peroxisome formation in Hansenula polymorpha: a sharp increase of the protein level induces the proliferation of numerous, small protein-import competent peroxisomes. Yeast 13, 1449-1463.
    • (1997) Yeast , vol.13 , pp. 1449-1463
    • Baerends, R.J.S.1    Salomons, F.A.2    Kiel, J.A.K.W.3    Van Der Klei, I.J.4    Veenhuis, M.5
  • 5
    • 0029328549 scopus 로고
    • A 200-amino-acid ATPase module in search of a basic function
    • Confalonieri, F. and Duguet, M. (1995). A 200-amino-acid ATPase module in search of a basic function. BioEssays 17, 639-650.
    • (1995) BioEssays , vol.17 , pp. 639-650
    • Confalonieri, F.1    Duguet, M.2
  • 7
    • 0022382166 scopus 로고
    • Dihydroxy-acetone synthase is localized in the peroxisomal matrix of methanol grown Hansenula polymorpha
    • Douma, A. C., Veenhuis, M., de Koning, W., Evers, M. and Harder, W. (1985). Dihydroxy-acetone synthase is localized in the peroxisomal matrix of methanol grown Hansenula polymorpha. Arch. Microbiol. 143, 237-243.
    • (1985) Arch. Microbiol. , vol.143 , pp. 237-243
    • Douma, A.C.1    Veenhuis, M.2    De Koning, W.3    Evers, M.4    Harder, W.5
  • 8
    • 0025965277 scopus 로고
    • PAS1, a yeast gene required for peroxisome biogenesis, encodes a member of a novel family of putative ATPases
    • Erdmann, R., Wiebel, F. F., Flessau, A., Rytka, J., Beyer, A., Fröhlich, K-U. and Kunau, W-H. (1991). PAS1, a yeast gene required for peroxisome biogenesis, encodes a member of a novel family of putative ATPases. Cell 64, 499-510.
    • (1991) Cell , vol.64 , pp. 499-510
    • Erdmann, R.1    Wiebel, F.F.2    Flessau, A.3    Rytka, J.4    Beyer, A.5    Fröhlich, K.-U.6    Kunau, W.-H.7
  • 10
    • 0027487375 scopus 로고
    • Watermelon glyoxysomal malate dehydrogenase is sorted to peroxisomes of the methylotrophic yeast Hansenula polymorpha
    • Faber, K. N., van der Klei, I. J., Keizer-Gunnink, I., Gietl, C., Harder, W. and Veenhuis, M. (1993). Watermelon glyoxysomal malate dehydrogenase is sorted to peroxisomes of the methylotrophic yeast Hansenula polymorpha. FEBS Lett. 334, 128-132.
    • (1993) FEBS Lett. , vol.334 , pp. 128-132
    • Faber, K.N.1    Van Der Klei, I.J.2    Keizer-Gunnink, I.3    Gietl, C.4    Harder, W.5    Veenhuis, M.6
  • 11
    • 0028217090 scopus 로고
    • Highly efficient electrotransformation of the yeast Hansenula polymorpha
    • Faber, K. N., Haima, P., Harder, W., Veenhuis, M. and AB, G. (1994). Highly efficient electrotransformation of the yeast Hansenula polymorpha. Curr. Genet. 25, 305-310.
    • (1994) Curr. Genet. , vol.25 , pp. 305-310
    • Faber, K.N.1    Haima, P.2    Harder, W.3    Veenhuis, M.4    Ab, G.5
  • 12
    • 0031930956 scopus 로고    scopus 로고
    • Two AAA family peroxins, PpPex1p and PpPex6p, interact with each other in an ATP-dependent manner and are associated with different subcellular membranous structures distinct from peroxisomes
    • Faber, K. N., Heyman, J. A. and Subramani, S. (1998). Two AAA family peroxins, PpPex1p and PpPex6p, interact with each other in an ATP-dependent manner and are associated with different subcellular membranous structures distinct from peroxisomes. Mol. Cell. Biol. 18, 936-943.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 936-943
    • Faber, K.N.1    Heyman, J.A.2    Subramani, S.3
  • 13
    • 0024406857 scopus 로고
    • A novel genetic system to detect protein-protein interactions
    • Fields, S. and Song, O. (1989). A novel genetic system to detect protein-protein interactions. Nature 340, 245-247.
    • (1989) Nature , vol.340 , pp. 245-247
    • Fields, S.1    Song, O.2
  • 15
    • 0032555273 scopus 로고    scopus 로고
    • Disruption of the PEX1-PEX6 interaction is the most common cause of the neurological disorders Zellweger syndrome, neonatal adrenoleukodystrophy, and infantile Refsum disease
    • Geisbrecht, B. V., Collins, C. S., Reuber, B. E. and Gould, S. J. (1998). Disruption of the PEX1-PEX6 interaction is the most common cause of the neurological disorders Zellweger syndrome, neonatal adrenoleukodystrophy, and infantile Refsum disease. Proc. Natl Acad. Sci. U S A 95, 8630-8635.
    • (1998) Proc. Natl Acad. Sci. U S A , vol.95 , pp. 8630-8635
    • Geisbrecht, B.V.1    Collins, C.S.2    Reuber, B.E.3    Gould, S.J.4
  • 16
    • 0028180512 scopus 로고
    • Mutational analysis of the N-terminal topogenic signal of watermelon glyoxysomal malate dehydrogenase using the heterologous host Hansenula polymorpha
    • Gietl, C., Faber, K. N., van der Klei, I. J. and Veenhuis, M. (1994). Mutational analysis of the N-terminal topogenic signal of watermelon glyoxysomal malate dehydrogenase using the heterologous host Hansenula polymorpha. Proc. Natl Acad. Sci. USA 91, 3151-3155.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 3151-3155
    • Gietl, C.1    Faber, K.N.2    Van Der Klei, I.J.3    Veenhuis, M.4
  • 17
    • 84990723635 scopus 로고
    • Genetic analysis in the methylotrophic yeast Hansenula polymorpha
    • Gleeson, M. A. and Sudbery, P. E. (1988). Genetic analysis in the methylotrophic yeast Hansenula polymorpha. Yeast 4, 293-303.
    • (1988) Yeast , vol.4 , pp. 293-303
    • Gleeson, M.A.1    Sudbery, P.E.2
  • 18
    • 0028043638 scopus 로고
    • Role of the PAS1 gene of Pichia pastoris in peroxisome biogenesis
    • Heyman, J. A., Monosov, E. and Subramani, S. (1994). Role of the PAS1 gene of Pichia pastoris in peroxisome biogenesis. J. Cell Biol. 127, 1259-1273.
    • (1994) J. Cell Biol. , vol.127 , pp. 1259-1273
    • Heyman, J.A.1    Monosov, E.2    Subramani, S.3
  • 19
    • 0031023643 scopus 로고    scopus 로고
    • The Hansenula polymorpha PEX14 gene encodes a novel peroxisomal membrane protein essential for peroxisome biogenesis
    • Komori, M., Rasmussen, S. W., Kiel, J. A. K. W., Baerends, R. J. S., Cregg, J. M., van der Klei, I. J. and Veenhuis, M. (1997). The Hansenula polymorpha PEX14 gene encodes a novel peroxisomal membrane protein essential for peroxisome biogenesis. EMBO J. 16, 44-53.
    • (1997) EMBO J. , vol.16 , pp. 44-53
    • Komori, M.1    Rasmussen, S.W.2    Kiel, J.A.K.W.3    Baerends, R.J.S.4    Cregg, J.M.5    Van Der Klei, I.J.6    Veenhuis, M.7
  • 20
    • 0028588987 scopus 로고
    • Effect of site-directed mutagenesis of conserved lysine residues upon Pasl protein function in peroxisome biogenesis
    • Krause, T., Kunau, W-H. and Erdmann, R. (1994). Effect of site-directed mutagenesis of conserved lysine residues upon Pasl protein function in peroxisome biogenesis. Yeast 10, 1613-1620.
    • (1994) Yeast , vol.10 , pp. 1613-1620
    • Krause, T.1    Kunau, W.-H.2    Erdmann, R.3
  • 21
    • 0032559985 scopus 로고    scopus 로고
    • Peroxisome biogenesis: Back to the endoplasmic reticulum?
    • Kunau, W-H. and Erdmann, R. (1998). Peroxisome biogenesis: back to the endoplasmic reticulum? Curr. Biol. 8, R299-302.
    • (1998) Curr. Biol. , vol.8
    • Kunau, W.-H.1    Erdmann, R.2
  • 23
    • 0027371995 scopus 로고
    • Cloning and sequencing of the URA3 locus of the methylotrophic yeast Hansenula polymorpha and its use for the generation of a deletion by gene replacement
    • Merckelbach, A., Gödecke, S., Janowicz, Z. A. and Hollenberg, C. P. (1993). Cloning and sequencing of the URA3 locus of the methylotrophic yeast Hansenula polymorpha and its use for the generation of a deletion by gene replacement. Appl. Microbiol. Biotechnol. 40, 361-364.
    • (1993) Appl. Microbiol. Biotechnol. , vol.40 , pp. 361-364
    • Merckelbach, A.1    Gödecke, S.2    Janowicz, Z.A.3    Hollenberg, C.P.4
  • 25
    • 0028012453 scopus 로고
    • PAY4, a gene required for peroxisome assembly in the yeast Yarrowia lipolytica, encodes a novel member of a family of putative ATPases
    • Nuttley, W. M., Brade, A. M., Eitzen, G. A., Veenhuis, M., Aitchison, J. D., Szilard, R. K., Glover, J. R. and Rachubinski, R. A. (1994). PAY4, a gene required for peroxisome assembly in the yeast Yarrowia lipolytica, encodes a novel member of a family of putative ATPases. J. Biol. Chem. 269, 556-566.
    • (1994) J. Biol. Chem. , vol.269 , pp. 556-566
    • Nuttley, W.M.1    Brade, A.M.2    Eitzen, G.A.3    Veenhuis, M.4    Aitchison, J.D.5    Szilard, R.K.6    Glover, J.R.7    Rachubinski, R.A.8
  • 26
    • 0030720859 scopus 로고    scopus 로고
    • Human PEX1 is mutated in complementation group 1 of the peroxisome biogenesis disorders
    • Portsteffen, H., Beyer, A., Becker, E., Epplen, C., Pawlak, A., Kunau, W. H. and Dodt, G. (1997). Human PEX1 is mutated in complementation group 1 of the peroxisome biogenesis disorders. Nature Genet. 17, 449-452.
    • (1997) Nature Genet. , vol.17 , pp. 449-452
    • Portsteffen, H.1    Beyer, A.2    Becker, E.3    Epplen, C.4    Pawlak, A.5    Kunau, W.H.6    Dodt, G.7
  • 27
    • 0029146098 scopus 로고
    • Identification of peroxisomal membrane ghosts with an epitopetagged integral membrane protein in yeast mutants lacking peroxisomes
    • Purdue, P. E. and Lazarow, P. B. (1995). Identification of peroxisomal membrane ghosts with an epitopetagged integral membrane protein in yeast mutants lacking peroxisomes. Yeast 11, 1045-1060.
    • (1995) Yeast , vol.11 , pp. 1045-1060
    • Purdue, P.E.1    Lazarow, P.B.2
  • 28
    • 0027414074 scopus 로고
    • The multicatalytic and 26 S proteases
    • Rechsteiner, M., Hoffman, L. and Dubiel, W. (1993). The multicatalytic and 26 S proteases. J. Biol. Chem. 268, 6065-6068.
    • (1993) J. Biol. Chem. , vol.268 , pp. 6065-6068
    • Rechsteiner, M.1    Hoffman, L.2    Dubiel, W.3
  • 29
    • 0007827843 scopus 로고    scopus 로고
    • Peroxisomes: Biology and their role in toxicology and disease
    • Reddy, J. K., Suga, T., Mannaerts, G. P., Lazarow, P. B. and Subramani, S. (eds) (1996). Peroxisomes: biology and Their Role in Toxicology and Disease. Ann. NY Acad. Sci., Vol. 804.
    • (1996) Ann. NY Acad. Sci. , vol.804
    • Reddy, J.K.1    Suga, T.2    Mannaerts, G.P.3    Lazarow, P.B.4
  • 32
    • 0027420719 scopus 로고
    • Cloning and characterization of PAS5: A gene required for peroxisome biogenesis in the methylotrophic yeast Pichia pastoris
    • Spong, A. P. and Subramani, S. (1993). Cloning and characterization of PAS5: A gene required for peroxisome biogenesis in the methylotrophic yeast Pichia pastoris. J. Cell Biol. 123, 535-548.
    • (1993) J. Cell Biol. , vol.123 , pp. 535-548
    • Spong, A.P.1    Subramani, S.2
  • 33
    • 0032515992 scopus 로고    scopus 로고
    • Human PEX1 cloned by functional complementation of a CHO cell mutant is responsible for peroxisome-deficient Zellweger syndrome of complementation group I
    • Tamura, S., Okumoto, K., Toyama, R., Shimozawa, N., Tsukamoto, T., Suzuki, Y., Osumi, T., Kondo, N. and Fujiki, Y. (1998a). Human PEX1 cloned by functional complementation of a CHO cell mutant is responsible for peroxisome-deficient Zellweger syndrome of complementation group I. Proc. Natl Acad. Sci. U S A 95, 4350-4355.
    • (1998) Proc. Natl Acad. Sci. U S A , vol.95 , pp. 4350-4355
    • Tamura, S.1    Okumoto, K.2    Toyama, R.3    Shimozawa, N.4    Tsukamoto, T.5    Suzuki, Y.6    Osumi, T.7    Kondo, N.8    Fujiki, Y.9
  • 35
    • 0028911539 scopus 로고
    • The Hansenula polymorpha PER8 gene encodes a novel peroxisomal integral membrane protein involved in proliferation
    • Tan, X., Waterham, H. R., Veenhuis, M. and Cregg, J. M. (1995). The Hansenula polymorpha PER8 gene encodes a novel peroxisomal integral membrane protein involved in proliferation. J. Cell Biol. 128, 307-319.
    • (1995) J. Cell Biol. , vol.128 , pp. 307-319
    • Tan, X.1    Waterham, H.R.2    Veenhuis, M.3    Cregg, J.M.4
  • 36
    • 0027290724 scopus 로고
    • Peroxisome biogenesis in the yeast Hansenula polymorpha is controlled by a complex set of interacting gene products
    • Titorenko, V. I., Waterham, H. R. W., Cregg, J. M., Harder, W. and Veenhuis, M. (1993). Peroxisome biogenesis in the yeast Hansenula polymorpha is controlled by a complex set of interacting gene products. Proc. Natl Acad. Sci. U S A 90, 7470-7474.
    • (1993) Proc. Natl Acad. Sci. U S A , vol.90 , pp. 7470-7474
    • Titorenko, V.I.1    Waterham, H.R.W.2    Cregg, J.M.3    Harder, W.4    Veenhuis, M.5
  • 37
    • 0031858109 scopus 로고    scopus 로고
    • The endoplasmic reticulum plays an essential role in peroxisome biogenesis
    • Titorenko, V. I. and Rachubinski, R. A. (1998). The endoplasmic reticulum plays an essential role in peroxisome biogenesis. Trends Biol. Sci. 23, 231-233.
    • (1998) Trends Biol. Sci. , vol.23 , pp. 231-233
    • Titorenko, V.I.1    Rachubinski, R.A.2
  • 40
    • 3042732458 scopus 로고    scopus 로고
    • A molecular analysis of peroxisome biogenesis and function in Hansenula polymorpha: A structural and functional analysis
    • Reddy, J. K., Suga, T., Mannaerts, G. P., Lazarow, P. B. and Subramani, S. (Eds), Peroxisomes: Biology and Their Role in Toxicology and Diseasel.
    • Van der Klei, I. J. and Veenhuis, M. (1996). A molecular analysis of peroxisome biogenesis and function in Hansenula polymorpha: a structural and functional analysis. In Reddy, J. K., Suga, T., Mannaerts, G. P., Lazarow, P. B. and Subramani, S. (Eds), Peroxisomes: Biology and Their Role in Toxicology and Diseasel. Ann. NY Acad. Sci., Vol. 804, pp. 47-59.
    • (1996) Ann. NY Acad. Sci. , vol.804 , pp. 47-59
    • Van Der Klei, I.J.1    Veenhuis, M.2
  • 41
    • 0032127487 scopus 로고    scopus 로고
    • The ubiquitin-conjugating enzyme Pex4p of Hansenula polymorpha is required for efficient functioning of the PTS1 import machinery
    • Van der Klei, I. J., Hilbrands, R. E., Kiel, J. A. K. W., Rasmussen, S. W., Cregg, J. M. and Veenhuis, M. (1998a). The ubiquitin-conjugating enzyme Pex4p of Hansenula polymorpha is required for efficient functioning of the PTS1 import machinery. EMBO J. 17, 3608-3618.
    • (1998) EMBO J. , vol.17 , pp. 3608-3618
    • Van Der Klei, I.J.1    Hilbrands, R.E.2    Kiel, J.A.K.W.3    Rasmussen, S.W.4    Cregg, J.M.5    Veenhuis, M.6
  • 42
    • 0031819848 scopus 로고    scopus 로고
    • The Hansenula polymorpha per6 mutant is affected in two adjacent genes which encode dihydroxyacetone kinase and a novel protein, Pak1p, involved in peroxisome integrity
    • Van der Klei, I. J., Van der Heide, M., Baerends, R. J. S., Rechinger, K. B., Nicolay, K., Kiel, J. A. K. W. and Veenhuis, M. (1998b). The Hansenula polymorpha per6 mutant is affected in two adjacent genes which encode dihydroxyacetone kinase and a novel protein, Pak1p, involved in peroxisome integrity. Curr. Genet. 34, 1-11.
    • (1998) Curr. Genet. , vol.34 , pp. 1-11
    • Van Der Klei, I.J.1    Van Der Heide, M.2    Baerends, R.J.S.3    Rechinger, K.B.4    Nicolay, K.5    Kiel, J.A.K.W.6    Veenhuis, M.7
  • 43
    • 0017151579 scopus 로고
    • Growth of Hansenula polymorpha in a methanollimited chemostat. Physiological responses due to the involvement of methanol oxidase as a key enzyme in methanol metabolism
    • Van Dijken, J. P., Otto, R. and Harder, W. (1976). Growth of Hansenula polymorpha in a methanollimited chemostat. Physiological responses due to the involvement of methanol oxidase as a key enzyme in methanol metabolism. Arch. Microbiol. 111, 137-144.
    • (1976) Arch. Microbiol. , vol.111 , pp. 137-144
    • Van Dijken, J.P.1    Otto, R.2    Harder, W.3
  • 44
    • 0000369467 scopus 로고
    • Microbodies
    • Rose, A. (Ed.), Academic Press, New York
    • Veenhuis, M. and Harder, W. (1991). Microbodies. In Rose, A. (Ed.), The Yeasts, Vol. 4. Academic Press, New York, pp. 601-653.
    • (1991) The Yeasts , vol.4 , pp. 601-653
    • Veenhuis, M.1    Harder, W.2
  • 46
    • 0027488612 scopus 로고
    • Sequence of the PAS8 gene, the product of which is essential for biogenesis of peroxisomes in Saccharomyces cerevisiae
    • Voorn-Brouwer, T., van der Leij, I., Hemrika, W., Distel, B. and Tabak, H. F. (1993). Sequence of the PAS8 gene, the product of which is essential for biogenesis of peroxisomes in Saccharomyces cerevisiae. Biochim. Biophys. Acta 1216, 325-328.
    • (1993) Biochim. Biophys. Acta , vol.1216 , pp. 325-328
    • Voorn-Brouwer, T.1    Van Der Leij, I.2    Hemrika, W.3    Distel, B.4    Tabak, H.F.5
  • 47
    • 0028061714 scopus 로고
    • The Hansenula polymorpha PER1 gene is essential for peroxisome biogenesis and encodes a peroxisomal matrix protein with both carboxy- and aminoterminal targeting sequences
    • Waterham, H. R., Titorenko, V. I., Haima, P., Cregg, J. M., Harder, W. and Veenhuis, M. (1994). The Hansenula polymorpha PER1 gene is essential for peroxisome biogenesis and encodes a peroxisomal matrix protein with both carboxy-and aminoterminal targeting sequences. J. Cell Biol. 127, 737-749.
    • (1994) J. Cell Biol. , vol.127 , pp. 737-749
    • Waterham, H.R.1    Titorenko, V.I.2    Haima, P.3    Cregg, J.M.4    Harder, W.5    Veenhuis, M.6
  • 48
    • 0029888487 scopus 로고    scopus 로고
    • The peroxisome biogenesis disorder group 4 gene, PXAAA1, encodes a cytoplasmic ATPase required for stability of the PTS1 receptor
    • Yahraus, T., Braverman, N., Dodt, G., Kalish, J. E., Morrell, J. C., Moser, H. W., Valle, D. and Gould, S. J. (1996). The peroxisome biogenesis disorder group 4 gene, PXAAA1, encodes a cytoplasmic ATPase required for stability of the PTS1 receptor. EMBO J. 15, 2914-2923.
    • (1996) EMBO J. , vol.15 , pp. 2914-2923
    • Yahraus, T.1    Braverman, N.2    Dodt, G.3    Kalish, J.E.4    Morrell, J.C.5    Moser, H.W.6    Valle, D.7    Gould, S.J.8
  • 49
    • 0021943518 scopus 로고
    • Improved M13 phage cloning vectors and host strains: Nucleotide sequence of the M13mp18 and pUC19 vectors
    • Yanisch-Perron, C., Vieira, J. and Messing, J. (1985). Improved M13 phage cloning vectors and host strains: nucleotide sequence of the M13mp18 and pUC19 vectors. Gene 33, 103-119.
    • (1985) Gene , vol.33 , pp. 103-119
    • Yanisch-Perron, C.1    Vieira, J.2    Messing, J.3


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