메뉴 건너뛰기




Volumn 17, Issue 13, 1998, Pages 3608-3618

The ubiquitin-conjugating enzyme Pex4p of Hansenula polymorpha is required for efficient functioning of the PTS1 import machinery

Author keywords

Peroxisome deficient mutant; Protein import; PTS1 receptor; Yeast

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING); MALATE SYNTHASE; MATRIX PROTEIN; MEMBRANE RECEPTOR; UBIQUITIN CONJUGATING ENZYME;

EID: 0032127487     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.13.3608     Document Type: Article
Times cited : (88)

References (41)
  • 1
    • 0029989855 scopus 로고    scopus 로고
    • FtsH (HflB) is an ATP-dependent protease selectively acting on SecY and some other membrane proteins
    • Akiyama, Y., Kihara, A., Tokuda, H. and Ito, K. (1996) FtsH (HflB) is an ATP-dependent protease selectively acting on SecY and some other membrane proteins. J. Biol. Chem., 271, 31196-31201.
    • (1996) J. Biol. Chem. , vol.271 , pp. 31196-31201
    • Akiyama, Y.1    Kihara, A.2    Tokuda, H.3    Ito, K.4
  • 3
    • 15844391797 scopus 로고    scopus 로고
    • The Hansenula polymorpha PER9 gene encodes a peroxisomal membrane protein, essential for peroxisome assembly and integrity
    • Baerends, R.J.S. et al. (1996) The Hansenula polymorpha PER9 gene encodes a peroxisomal membrane protein, essential for peroxisome assembly and integrity. J. Biol. Chem., 271, 8887-8894.
    • (1996) J. Biol. Chem. , vol.271 , pp. 8887-8894
    • Baerends, R.J.S.1
  • 4
    • 0030659441 scopus 로고    scopus 로고
    • Deviant Pex3p levels affect normal peroxisome formation in Hansenula polymorpha; high steady state levels of the protein fully abolish matrix protein import
    • Baerends, R.J.S., Salomons, F.A., Faber, K.N., Kiel, J.A.K.W., van der Klei, I.J. and Veenhuis, M. (1997a) Deviant Pex3p levels affect normal peroxisome formation in Hansenula polymorpha; high steady state levels of the protein fully abolish matrix protein import. Yeast, 13, 1437-1448.
    • (1997) Yeast , vol.13 , pp. 1437-1448
    • Baerends, R.J.S.1    Salomons, F.A.2    Faber, K.N.3    Kiel, J.A.K.W.4    Van Der Klei, I.J.5    Veenhuis, M.6
  • 5
    • 0030656970 scopus 로고    scopus 로고
    • Deviant Pex3p levels affect normal peroxisome formation in Hansenula polymorpha; a sharp increase of the protein level induces the proliferation of numerous, small protein-import competent peroxisomes
    • Baerends, R.J.S., Salomons, F.A., Kiel, J.A.K.W., van der Klei, I.J. and Veenhuis, M. (1997b) Deviant Pex3p levels affect normal peroxisome formation in Hansenula polymorpha; a sharp increase of the protein level induces the proliferation of numerous, small protein-import competent peroxisomes. Yeast, 13, 1449-1463.
    • (1997) Yeast , vol.13 , pp. 1449-1463
    • Baerends, R.J.S.1    Salomons, F.A.2    Kiel, J.A.K.W.3    Van Der Klei, I.J.4    Veenhuis, M.5
  • 6
    • 0026201547 scopus 로고
    • Characterization of the integral membrane polypeptides of rat liver peroxisomes isolated from untreated and clofibrate-treated rats
    • Bodnar, A.G. and Rachubinski, R.A. (1991) Characterization of the integral membrane polypeptides of rat liver peroxisomes isolated from untreated and clofibrate-treated rats. Biochem. Cell. Biol. 69, 499-508.
    • (1991) Biochem. Cell. Biol. , vol.69 , pp. 499-508
    • Bodnar, A.G.1    Rachubinski, R.A.2
  • 7
    • 0030004897 scopus 로고    scopus 로고
    • Site-specific phosphorylation of IkBα by a novel ubiquitination-dependent protein kinase activity
    • Chen, Z.J., Parent, L. and Maniatis, T. (1996) Site-specific phosphorylation of IkBα by a novel ubiquitination-dependent protein kinase activity. Cell, 84, 853-862.
    • (1996) Cell , vol.84 , pp. 853-862
    • Chen, Z.J.1    Parent, L.2    Maniatis, T.3
  • 8
    • 0028110821 scopus 로고
    • The Pichia pastoris PAS4 gene encodes a ubiquitin-conjugating enzyme required for peroxisome assembly
    • Crane, D.I., Kalish, J.E. and Gould, G.J. (1994) The Pichia pastoris PAS4 gene encodes a ubiquitin-conjugating enzyme required for peroxisome assembly. J. Biol. Chem., 269, 21835-21844.
    • (1994) J. Biol. Chem. , vol.269 , pp. 21835-21844
    • Crane, D.I.1    Kalish, J.E.2    Gould, G.J.3
  • 9
    • 0026767701 scopus 로고
    • Import of proteins into peroxisomes and other microbodies
    • de Hoop, M.J. and AB, G. (1992) Import of proteins into peroxisomes and other microbodies. Biochem. J., 286, 657-669.
    • (1992) Biochem. J. , vol.286 , pp. 657-669
    • De Hoop, M.J.1    Ab, G.2
  • 10
    • 0030459304 scopus 로고    scopus 로고
    • Multiple PEX genes are required for proper subcellular distribution and stability of Pex5p, the PTS1 receptor: Evidence that PTS1 protein import is mediated by a cycling receptor
    • Dodt, G. and Gould, S.J. (1996) Multiple PEX genes are required for proper subcellular distribution and stability of Pex5p, the PTS1 receptor: evidence that PTS1 protein import is mediated by a cycling receptor. J. Cell Biol., 135, 1763-1774.
    • (1996) J. Cell Biol. , vol.135 , pp. 1763-1774
    • Dodt, G.1    Gould, S.J.2
  • 11
    • 0022382166 scopus 로고
    • Dihydroxy-acetone synthase is localized in the peroxisomal matrix of methanol grown Hansenula polymorpha
    • Douma, A.C., Veenhuis, M., de Koning, W., Evers, M. and Harder, W. (1985) Dihydroxy-acetone synthase is localized in the peroxisomal matrix of methanol grown Hansenula polymorpha. Arch. Microbiol., 143, 237-243.
    • (1985) Arch. Microbiol. , vol.143 , pp. 237-243
    • Douma, A.C.1    Veenhuis, M.2    De Koning, W.3    Evers, M.4    Harder, W.5
  • 12
    • 0029879509 scopus 로고    scopus 로고
    • The sorting sequence of the peroxisomal integral membrane protein PMP47 is contained within a short hydrophilic loop
    • Dyer, J.M., McNew, J.A. and Goodman, J.M. (1996) The sorting sequence of the peroxisomal integral membrane protein PMP47 is contained within a short hydrophilic loop. J. Cell Biol., 133, 269-280.
    • (1996) J. Cell Biol. , vol.133 , pp. 269-280
    • Dyer, J.M.1    McNew, J.A.2    Goodman, J.M.3
  • 13
    • 0030870711 scopus 로고    scopus 로고
    • Peroxisomes: Organelles at the crossroads
    • Erdmann, R., Veenhuis, M. and Kunau, W.H. (1997) Peroxisomes: organelles at the crossroads. Trends Cell Biol., 7, 400-407.
    • (1997) Trends Cell Biol. , vol.7 , pp. 400-407
    • Erdmann, R.1    Veenhuis, M.2    Kunau, W.H.3
  • 14
    • 0027933654 scopus 로고
    • Assembly of alcohol oxidase in peroxisomes of the yeast Hansenula polymorpha requires the cofactor flavin adenine dinucleotide
    • Evers, M.E., Titorenko, V.I., van der Klei, I.J., Harder, W. and Veenhuis, M. (1994) Assembly of alcohol oxidase in peroxisomes of the yeast Hansenula polymorpha requires the cofactor flavin adenine dinucleotide. Mol. Biol. Cell, 5, 829-837.
    • (1994) Mol. Biol. Cell , vol.5 , pp. 829-837
    • Evers, M.E.1    Titorenko, V.I.2    Van Der Klei, I.J.3    Harder, W.4    Veenhuis, M.5
  • 16
    • 0028217090 scopus 로고
    • Highly efficient electrotransformation of the yeast Hansenula polymorpha
    • Faber, K.N., Haima, P., Harder, W., Veenhuis, M. and AB, G. (1994) Highly efficient electrotransformation of the yeast Hansenula polymorpha. Curr: Genet., 25, 305-310.
    • (1994) Curr: Genet. , vol.25 , pp. 305-310
    • Faber, K.N.1    Haima, P.2    Harder, W.3    Veenhuis, M.4    Ab, G.5
  • 17
    • 0028180512 scopus 로고
    • Mutational analysis of the N-terminal topogenic signal of watermelon glyoxisomal malate dehydrogenase using the heterologous host Hansenula polymorpha
    • Gietl, C., Faber, K.N., van der Klei, I.J. and Veenhuis, M. (1994) Mutational analysis of the N-terminal topogenic signal of watermelon glyoxisomal malate dehydrogenase using the heterologous host Hansenula polymorpha. Proc. Natl Acad. Sci. USA, 91, 3151-3155.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 3151-3155
    • Gietl, C.1    Faber, K.N.2    Van Der Klei, I.J.3    Veenhuis, M.4
  • 19
    • 0026706469 scopus 로고
    • Development of the yeast Pichia pastoris as a model organism for a genetic and molecular analysis of peroxisome assembly
    • Gould, S.J., McCollum, D., Spong, A.P., Heyman, J.A. and Subramani, S. (1992) Development of the yeast Pichia pastoris as a model organism for a genetic and molecular analysis of peroxisome assembly. Yeast, 8, 613-628.
    • (1992) Yeast , vol.8 , pp. 613-628
    • Gould, S.J.1    McCollum, D.2    Spong, A.P.3    Heyman, J.A.4    Subramani, S.5
  • 20
    • 0029870836 scopus 로고    scopus 로고
    • Protein degradation of regulation: Ub the judge
    • Hochstrasser, M. (1996) Protein degradation of regulation: Ub the judge. Cell. 84, 813-815.
    • (1996) Cell , vol.84 , pp. 813-815
    • Hochstrasser, M.1
  • 21
    • 0031023643 scopus 로고    scopus 로고
    • The Hansenula polymorpha PEX14 gene encodes a novel peroxisomal membrane protein essential for peroxisome biogenesis
    • Komori, M., Rasmussen, S.W., Kiel, J.A.K.W., Baerends, R.J.S., Cregg, J.M., van der Klei, I.J. and Veenhuis, M. (1997) The Hansenula polymorpha PEX14 gene encodes a novel peroxisomal membrane protein essential for peroxisome biogenesis. EMBO J., 16, 44-53.
    • (1997) EMBO J. , vol.16 , pp. 44-53
    • Komori, M.1    Rasmussen, S.W.2    Kiel, J.A.K.W.3    Baerends, R.J.S.4    Cregg, J.M.5    Van Der Klei, I.J.6    Veenhuis, M.7
  • 22
    • 0021678736 scopus 로고
    • Electroblotting of multiple gels: A simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose
    • Kyhse-Andersen, J. (1984) Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose. J. Biochem. Biophys. Methods. 10, 203-209.
    • (1984) J. Biochem. Biophys. Methods. , vol.10 , pp. 203-209
    • Kyhse-Andersen, J.1
  • 23
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 227, 680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 24
    • 0002191974 scopus 로고
    • Catalase
    • Bergmeyer, H.U. (ed.). Academic Press, New York
    • Lück, H. (1963) Catalase. In Bergmeyer, H.U. (ed.). Methods of Enzymatic Analysis. Academic Press, New York, pp. 885-894.
    • (1963) Methods of Enzymatic Analysis , pp. 885-894
    • Lück, H.1
  • 25
    • 85047669202 scopus 로고    scopus 로고
    • The targeting and assembly of peroxisomal proteins: Some old rules do not apply
    • McNew, J.A. and Goodman, J.M. (1996) The targeting and assembly of peroxisomal proteins: some old rules do not apply. Trends Biochem. Sci., 21, 54-58.
    • (1996) Trends Biochem. Sci. , vol.21 , pp. 54-58
    • McNew, J.A.1    Goodman, J.M.2
  • 26
    • 0027371995 scopus 로고
    • Cloning and sequencing of the URA3 locus of the methylotrophic yeast Hansenula polymorpha and its use for the generation of a deletion by gene replacement
    • Merckelbach, A., Gödecke, S., Janowicz, Z.A. and Hollenberg, C.P. (1993) Cloning and sequencing of the URA3 locus of the methylotrophic yeast Hansenula polymorpha and its use for the generation of a deletion by gene replacement. Appl. Microbiol. Biotechnol., 40, 361-364.
    • (1993) Appl. Microbiol. Biotechnol. , vol.40 , pp. 361-364
    • Merckelbach, A.1    Gödecke, S.2    Janowicz, Z.A.3    Hollenberg, C.P.4
  • 27
    • 0028783455 scopus 로고
    • How proteins penetrate peroxisomes?
    • Rachubinski, R. and Subramani, S. (1995) How proteins penetrate peroxisomes? Cell, 83, 525-528.
    • (1995) Cell , vol.83 , pp. 525-528
    • Rachubinski, R.1    Subramani, S.2
  • 29
    • 0027333416 scopus 로고
    • Protein import into peroxisomes and biogenesis of the organelle
    • Subramani, S. (1993) Protein import into peroxisomes and biogenesis of the organelle. Annu. Rev. Cell Biol., 9, 445-478.
    • (1993) Annu. Rev. Cell Biol. , vol.9 , pp. 445-478
    • Subramani, S.1
  • 30
    • 0030222363 scopus 로고    scopus 로고
    • Convergence of model systems for peroxisome biogenesis
    • Subramani, S. (1996) Convergence of model systems for peroxisome biogenesis. Curr. Opin. Cell Biol., 8, 513-518.
    • (1996) Curr. Opin. Cell Biol. , vol.8 , pp. 513-518
    • Subramani, S.1
  • 31
    • 0028911539 scopus 로고
    • The Hansenula polymorpha PER8 gene encodes a novel peroxisomal integral membrane protein involved in proliferation
    • Tan, X., Waterham, H.R., Veenhuis, M. and Cregg, J.M. (1995) The Hansenula polymorpha PER8 gene encodes a novel peroxisomal integral membrane protein involved in proliferation. J. Cell Biol., 128, 307-319.
    • (1995) J. Cell Biol. , vol.128 , pp. 307-319
    • Tan, X.1    Waterham, H.R.2    Veenhuis, M.3    Cregg, J.M.4
  • 32
    • 0027290724 scopus 로고
    • Peroxisome biogenesis in the yeast Hansenula polymorpha is controlled by a complex set of interacting gene products
    • Titorenko, V.I., Waterham, H.R.W., Cregg, J.M., Harder, W. and Veenhuis, M. (1993) Peroxisome biogenesis in the yeast Hansenula polymorpha is controlled by a complex set of interacting gene products. Proc. Natl Acad. Sci. USA, 90, 7470-7474.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 7470-7474
    • Titorenko, V.I.1    Waterham, H.R.W.2    Cregg, J.M.3    Harder, W.4    Veenhuis, M.5
  • 34
    • 0017151579 scopus 로고
    • Growth of Hansenula polymorpha in a methanol-limited chemostat. Physiological responses due to the involvement of methanol oxidase as a key enzyme in methanol metabolism
    • van Dijken, J.P., Otto, R. and Harder, W. (1976) Growth of Hansenula polymorpha in a methanol-limited chemostat. Physiological responses due to the involvement of methanol oxidase as a key enzyme in methanol metabolism. Arch. Microbiol., 111, 137-144.
    • (1976) Arch. Microbiol. , vol.111 , pp. 137-144
    • Van Dijken, J.P.1    Otto, R.2    Harder, W.3
  • 35
    • 3042732458 scopus 로고    scopus 로고
    • A molecular analysis of peroxisome biogenesis and function in Hansenula polymorpha: A structural and functional analysis
    • van der Klei, I.J. and Veenhuis, M. (1996) A molecular analysis of peroxisome biogenesis and function in Hansenula polymorpha: a structural and functional analysis. Ann. NY Acad. Sci., 804, 47-59.
    • (1996) Ann. NY Acad. Sci. , vol.804 , pp. 47-59
    • Van Der Klei, I.J.1    Veenhuis, M.2
  • 37
    • 0031819848 scopus 로고    scopus 로고
    • The Hansenula polymorpha per6 mutant is affected in two adjacent genes which encode dihydroxyacetone kinase and a novel protein, Pak1p, involved in peroxisome integrity
    • in press
    • van der Klei, I.J., van der Heide, M., Baerends, R.J.S., Rechinger, K.B., Nicolay, K., Kiel, J.A.K.W. and Veenhuis, M. (1998) The Hansenula polymorpha per6 mutant is affected in two adjacent genes which encode dihydroxyacetone kinase and a novel protein, Pak1p, involved in peroxisome integrity. Curr. Genet., in press
    • (1998) Curr. Genet.
    • Van Der Klei, I.J.1    Van Der Heide, M.2    Baerends, R.J.S.3    Rechinger, K.B.4    Nicolay, K.5    Kiel, J.A.K.W.6    Veenhuis, M.7
  • 38
    • 0017820576 scopus 로고
    • Development of crystalline peroxisomes in methanol-grown cells of the yeast Hansenula polymorpha and its relation to environmental conditions
    • Veenhuis, M., van Dijken, J.P., Pilon, S.A.F. and Harder, W. (1978) Development of crystalline peroxisomes in methanol-grown cells of the yeast Hansenula polymorpha and its relation to environmental conditions. Arch. Microbiol., 117, 153-163.
    • (1978) Arch. Microbiol. , vol.117 , pp. 153-163
    • Veenhuis, M.1    Van Dijken, J.P.2    Pilon, S.A.F.3    Harder, W.4
  • 40
    • 0028061714 scopus 로고
    • The Hansenula polymorpha PER1 gene is essential for peroxisome biogenesis and encodes a peroxisomal matrix protein with both carboxy- and amino-terminal targeting signals
    • Waterham, H.R., Titorenko, V.I., Haima, P., Cregg, J.M., Harder, W. and Veenhuis, M. (1994) The Hansenula polymorpha PER1 gene is essential for peroxisome biogenesis and encodes a peroxisomal matrix protein with both carboxy-and amino-terminal targeting signals. J. Cell Biol., 127, 737-749.
    • (1994) J. Cell Biol. , vol.127 , pp. 737-749
    • Waterham, H.R.1    Titorenko, V.I.2    Haima, P.3    Cregg, J.M.4    Harder, W.5    Veenhuis, M.6
  • 41
    • 0026782393 scopus 로고
    • The Pas2 protein essential for peroxisome biogenesis is related to ubiquitin-conjugating enzymes
    • Wiebel, F.F. and Kunau, W.H. (1992) The Pas2 protein essential for peroxisome biogenesis is related to ubiquitin-conjugating enzymes. Nature, 359, 73-76.
    • (1992) Nature , vol.359 , pp. 73-76
    • Wiebel, F.F.1    Kunau, W.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.