Altered hepatic mRNA expression of apoptotic genes during dimethylnitrosamine exposure

Toxicological Sciences

Volumn 57, Issue 2, 2000, Pages 240-249

  Horn, Thomas L ^a   Bhattacharjee, Arindam ^a   Schook, Lawrence B ^a   Rutherford, Mark S ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Apoptosis; Bax; Bcl X(L); Dimethylnitrosamine (DMN); Fas (CD95 APO 1); Hepatotoxicity; TNF

Indexed keywords

DIMETHYLNITROSAMINE; DNA; FAS ANTIGEN; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL X; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR;

ADOLESCENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA DEGRADATION; GENE EXPRESSION; KNOCKOUT MOUSE; LIVER TOXICITY; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0033800178     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/57.2.240     Document Type: Article

References (56)

1. The Bcl-2 protein family: Arbiters of cell survival
2. Mechanisms controlling cellular suicide: Role of Bcl-2 and caspases
3. Death receptors: Signaling and modulation
4. Molecular dissection of dimethylnitrosamine (DMN)-induced hepatotoxicity by mRNA differential display
5. Refinements in re-amplification and cloning of DDRT-PCR products
6. Role of proinflammatory cytokines in acetaminophen hepatotoxicity
7. Bcl-x, a bcl-2 related gene that functions as a dominant regulator of apoptotic cell death
8. Bcl-x(L) can inhibit apoptosis in cells that have undergone Fas-induced protease activation
9. Induction of early-immediate genes by tumor necrosis factor α contribute to liver repair following chemical-induced hepatotoxicity
10. A biochemical hallmark of apoptosis: Internucleosomal degradation of the genome
11. Expression of tumor necrosis factor-α and transforming growth factor-β1 in acute liver injury
12. A matter of life and cell death
13. Mitochondria and apoptosis
14. TNF receptors TR60 and TR80 can mediate apoptosis via induction of distinct signal pathways
15. Cadmium-induced apoptosis in mouse liver
16. Bcl-2 protein is topographically restricted in tissues characterized by apoptotic cell death
17. Acute hepatotoxicant exposure induces TNFR-mediated hepatic injury and cytokine/apoptotic gene expression
18. TNF-α is not required for hepatic metallothionein expression during endotoxin or dimethylnitrosamine exposure in vivo
19. Effect of bcl-2 on Fas antigen-mediated cell death
20. Role of tumor necrosis factor-or in cadmium-induced hepatotoxicity
21. Modulation of apoptosis-associated genes bcl-2, bcl-x, and bax during rat liver regeneration
22. Disparate roles for TNF-α and Fas ligand in concanavalin A-induced hepatitis
23. Induction of two different modes of cell death, apoptosis and necrosis, in rat liver after a single dose of thioacetamide
24. Rapid induction of apoptosis in rat liver by cyclohexamide
25. Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models
26. Activation of the 55 kDa TNF receptor is necessary and sufficient for TNF-induced liver failure, hepatocyte apoptosis, and nitrite release
27. Tumor necrosis factor-induced apoptosis during the poisoning of mice with hepatotoxins
28. Transcriptional changes in macrophage TNF-α expression following dimethylnitrosamine exposure in vivo
29. Induction of hepatic acute-phase protein transcripts: Differential effects of acute and subchronic dimethylnitrosamine exposure in vivo
30. Endotoxin-induced cytokine gene expression and excretion in the liver
31. Immunotoxicity of nitrosamines
32. The Fas death factor
33. Lethal effect of the anti-Fas antibody in mice
34. Studies on the mechanism of dimethylnitrosamine-induced acute liver injury in mice
35. Caspase-9, Bcl-X(L), and Apaf-1 form a ternary complex
36. TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation
37. Apoptosis - The mechanism of cell death in dimethylnitrosamine-induced hepatotoxicity
38. ++-endonuclease and poly(ADP-ribose) polymerase inhibitors in mice
39. 1,1-Dichloroethylene: An apoptotic hepatotoxin?
40. Tumour necrosis factor α (TNFα) suppresses apoptosis and induces DNA synthesis in rodent hepatocytes: A mediator of the hepatocarcinogenicity of peroxisome proliferators?
41. A simple and rapid method for detection of apoptosis in human cells
42. Analysis of genomic DNA by Southern hybridization
43. Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system
44. Dimethylnitrosamine (DMN)-induced IL-1β, TNF-α, and IL-6 inflammatory cytokine expression
45. Necrosis and apoptosis: Distinct modes of cell death with fundamentally different significance
46. Multiple Bcl-2 family members demonstrate selective dimerizations with Bax
47. Monoclonal antibodies specific for murine p55 and p75 tumor necrosis factor receptors: Identification of a novel in vivo role for p75
48. Evidence of hepatocyte apoptosis in rat liver after the administration of carbon tetrachloride
49. DNA adducts, mutant frequencies and mutation spectra in λlacZ transgenic mice treated with N-nitrosodimethylamine
50. Delayed Fas-mediated hepatocyte apoptosis during liver regeneration in mice: Hepatoprotective role of TNFα
51. Two TNF receptors
52. Ligand passing: The 75-kDa tumor necrosis factor (TNF) receptor recruits TNF for signaling by the 55-kDa TNF receptor
53. Depressed Langerhans cell migration and reduced contact hypersensitivity response in mice lacking TNF receptor p75
54. Tumour necrosis factor receptor II (p75) signalling is required for the migration of Langerhans' cells
55. Cell death: The significance of apoptosis
56. Induction of apoptosis in mature T cells by tumor necrosis factor