Molecular dissection of dimethylnitrosamine (DMN)-induced hepatotoxicity by mRNA differential display

Toxicology and Applied Pharmacology

Volumn 150, Issue 1, 1998, Pages 186-195

  Bhattacharjee, Arindam ^a   Lappi, Victoria R ^a   Rutherford, Mark S ^a   Schook, Lawrence B ^a,b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Cholesterol 7 hydroxylase; Differential display; Dimethylnitrosamine; Hepatotoxicity; Major urinary protein; Serum amyloid A

Indexed keywords

AMYLOID A PROTEIN; CHOLESTEROL 7ALPHA MONOOXYGENASE; COMPLEMENT COMPONENT C3; CYTOCHROME P450 ISOENZYME; DIMETHYLNITROSAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; FEMALE; GENETIC TRANSCRIPTION; IN SITU HYBRIDIZATION; LIVER TOXICITY; MOUSE; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS;

ANIMALIA;

EID: 0031807998     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1998.8392     Document Type: Article

References (32)

1. Appel, K. E., Ruhl, C. S., and Hildebrandt, A. G. (1984). Metabolic activation of N-nitrosamines by cytochrome P450 in vitro and in vivo. IARC Sci. Publ. 57, 443-455.
2. Bartsch, H. (1981). Detection of N-nitroso compounds as bacterial mutagens-past experience. In Safety Evaluation of Nitrosatable Drugs and Chemicals (G. G. Gibson and C. Ionnides, Eds.), pp. 185-197, Taylor and Francis, London, UK.
3. Belgrader, P., and Maquat, L. E. (1994). Nonsense but not missense mutations can decrease the abundance of nuclear mRNA for the mouse major urinary protein, while both types of mutations can facilitate exon skipping. Mol. Cell. Biol. 14, 6326-6336.
4. Bennett, A. L., Paulson, K. R., Miller, R. E., and Darnell, J. E. (1987). Aquisition of antigens characteristic of adult pericentral hepatocytes by differentiating fetal hepatoblast in vitro. J. Cell Biol. 105, 1073-1085.
5. Bhattacharjee, A., Rutherford, M. S., Abrahamsen, M. S., Lappi, V. R., and Schook, L. B. (1997). Refinements in re-amplification and cloning of DDRT-PCR products. BioTechniques 22, 1048-1051.
6. Crestani, M., Karam, W. G., and Chiang, Y. L. (1994). Effects of bile acids and steroid/thyroid hormones on the expression of cholesterol 7α-hydroxylase mRNA and the CYP7 gene in HepG2 cells. Biochem. Biophys. Res. Commun. 198, 546-553.
7. Guengerich, F. P. (1987). Mammalian Cytochrome P-450. CRC Press, Boca Raton, FL.
8. Haggerty, H. G., and Holsapple, M. P. (1990). Role of metabolism in dimethyl nitrosamine-induced immunosuppression. A review. Toxicologist 63, 1-23.
9. Hirata, K., Ogata, I., Ohta, Y., and Fujiwara, K. (1989). Hepatic sinusoidal cell destruction in the development of intravascular coagulation in acute liver failure in rats. J. Pathol. 158, 157-165.
10. Horn, T. L., O'Brien, T. D., Fraser, D. G., Rutherford, M. S., and Schook, L. B. (1997). Liver histopathology of TNF receptor knockout mice during dimethylnitrosamine (DMN) exposure in vivo. Toxicologist 36, 8.
11. Horn, T. L., Rutherford, M. S., and Schook, L. B. (1996). Alteration of proinflammatory gene expression and hepatic macrophage populations following dimethylnitrosamine exposure in vivo. Toxicologist 30, 327.
12. Kayama, F., Yoshida, T., Elwell, M. R., and Luster, M. I. (1995). Role of tumor necrosis factor-α in cadmium induced hepatotoxicity. Toxicol. Appl. Pharmacol. 131, 224-234.
13. Koop, D. R. (1992). Oxidative and reductive metabolism by cytochrome P450 2E1. FASEB J. 6, 724-730.
14. Kuhn, N. J., Woodwort-Gutai, M., Gross, K. W., and Held, W. A. (1984). Subfamilies of the mouse major urinary protein (MUP) multi-gene family: Sequence analysis of cDNA clones and dfferential regulation in the liver. Nucleic Acids Res. 12, 6073-6090.
15. Laskin, D. L. (1994). Nonparenchymal cells, inflammatory mediators, and hepatotoxicity. In Xenobiotics and Inflammation (L. B. Schook and D. L. Laskin, Eds.), pp. 301-320, Academic Press, Inc., Boca Raton, FL.
16. Lee, Y. H., Alberta, J. A., Gonzalez, F. J., and Waxman, D. J. (1994). Multiple functional DBP sites on the promoter of the cholesterol 7α-hydroxylase P450 gene, CYP7. Proposed role in diurnal regulation of liver gene expression. J. Biol. Chem. 269, 14681-14689.
17. Li, Y. C., Wang, D. P., and Chiang, Y. L. (1990). Regulation of cholesterol 7α-hydroxylase in the liver. J. Biol. Chem. 265, 12012-12019.
18. Liang, P., Averboukh, L., and Pardee, A. B. (1993). Distribution and cloning of eukaryotic mRNAs by means of differential display: Refinements and optimization. Nucleic Acids Res. 14, 3269-3275.
19. Lockwood, J. F., Rutherford, M. S., Myers, M. J., and Schook, L. B. (1994). Induction of hepatic acute phase protein transcripts: Differential effects of acute and subchronic dimethylnitrosamine (DMN) exposure in vivo. Toxicol. Appl. Pharmacol. 125, 288-295.
20. Lockwood, J. F., Shivers, J. L., O'Brien, T. D., and Schook, L. B. (1995). In situ detection of hepatic IL-6 transcript expression following acute DMN exposure. Toxicologist 15, 137.
21. Mancini, R., Paolucci, F., Svegliati-Baronon, G., Jazequel, A. M., and Orlindi, F. (1991). Phenotypic analysis of inflammatory infiltrate in rats with dimethylnitrosamine-induced cirrhosis. Int. J. Exp. Pathol. 72, 119-127.
22. Marchuk, D., Drum, M., Saulino, A., and Collins, F. S. (1991). Construction of T-vectors, a rapid and general system for direct cloning of unmodified PCR products. Nucleic Acids Res. 19, 1154.
23. Miller, M. S., Buzard, G. S., and McDowell, A. E. (1993). In vivo inhibition of glucocorticoid-inducible gene expression by dimethylnitrosamine in rat liver. Biochem. Pharmacol. 45, 1465-1470.
24. Myers, M. J., and Schook, L. B. (1996). Immunotoxicity of nitrosamines. In Experimental Immunotoxicology (R. J. Smialowicz and M. P. Holsapple, Eds.), pp. 351-356. CRC Press, Boca Raton, FL.
25. ++-endonuclease and poly (ADP-ribose) polymerase inhibitors in mice. J. Pharmacol. Exp. Ther. 263, 387-394.
26. Reik, W., Romer, I., Barton, S. C., Surani, M. A., Howlett, S. K., and Klose, J. (1993). Adult phenotypes in the mouse can be affected by epigenetic events in the early embryo. Development 119, 933-942.
27. Reitman, F. A., Berger, M. L., Minnema, D. J., and Shertzer, H. G. (1988). Calcium transport, thiol status, and hepatoxicity following N-nitrosodimethylamine exposure to mice. J. Toxicol. Environ. Health 23, 321-331.
28. Rogers, G. W., Dobbs, B. R., and Fraser, R. (1992). Decrease hepatic uptake of cholesterol and retinol in the dimethylnitrosamine rat model of cirrhosis. Liver 12, 326-329.
29. Rutherford, M. S., Horn, T. L., Bhattacharjee, A., and Schook, L. B. (1996). Temporal effects of TNF-α receptor signals during dimethylnitrosamine (DMN)-induced hepatotoxicity. Eur. Cytokine Network 7, 240.
30. Sambrook, J., Fitsch, E., and Maniatis, T. (1989). Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
31. Schook, L. B., Lockwood, J. F., Yang, S.-D., and Myers, M. J. (1992). Dimethylnitrosamine (DMN)-induced IL-1β, TNF-α, and IL-6 inflammatory cytokine expression. Toxicol. Appl. Pharmacol. 116, 110-116.
32. Shefer, S., Kren, B. T., Salen, G., Steer, C. J., Nguyen, L. B., Chen, T., Tint, G. S., and Batta, A. K. (1995). Regulation of bile acid synthesis by deoxycholic acid in the rat: Different effects on cholesterol 7α-hydroxylase and sterol 27-hydroxylase. Hepatology 22, 1215-1221.