A novel estrogen receptor variant mRNA lacking exons 4 to 6 in breast carcinoma

Journal of Steroid Biochemistry and Molecular Biology

Volumn 62, Issue 5-6, 1997, Pages 419-430

  Chan, Christina M W ^a   Dowsett, Mitchell ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; ESTROGEN RECEPTOR; PROGESTERONE RECEPTOR; TAMOXIFEN;

ALTERNATIVE RNA SPLICING; ARTICLE; BREAST CARCINOMA; CLINICAL ARTICLE; CONTROLLED STUDY; EXON; FEMALE; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LIGAND BINDING; PHENOTYPE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BREAST NEOPLASMS; CHO CELLS; CRICETINAE; DNA PRIMERS; DRUG RESISTANCE; ESTROGEN ANTAGONISTS; EXONS; FEMALE; HUMANS; MOLECULAR SEQUENCE DATA; NEOPLASMS, HORMONE-DEPENDENT; POLYMERASE CHAIN REACTION; RECEPTORS, ESTROGEN; RNA SPLICING; RNA, MESSENGER; RNA, NEOPLASM; TAMOXIFEN; TISSUE DISTRIBUTION; TRANSFECTION; TUMOR CELLS, CULTURED; VARIATION (GENETICS);

EID: 0031438883     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(97)00061-7     Document Type: Article

References (31)

1. Henderson I. C. and Canellos G. P., Cancer of the breast. The past decade. New England Journal of Medicine 302 (1980) 78-90.
2. Furr B. J. A. and Jordan V. C., The pharmacology and clinical uses of tamoxifen. Pharmacology and Therapeutics 25 (1984) 127-205.
3. Saez, R. A. and Osborne, C. K. (1989) In Current Clinical Oncology, ed. B. J. Kennedy. Alan R. Liss, New York, pp. 163-172.
4. Encarnacion C. A., Ciocca D. R., McGuire W. L., Clark G. M., Fuqua S. A. W. and Osborne C. K., Measurement of steroid hormone receptors in breast cancer patients on tamoxifen. Breast Cancer Research and Treatment 26 (1993) 237-246.
5. Osborne C. K., Mechanism for tamoxifen resistance in breast cancer: possible role of tamoxifen metabolism. Journal of Steroid Biochemistry and Molecular Biology: 47 (1993) 83-89.
6. Cox P. M. and Coding C. R., Transcription and cancer. British Journal of Cancer 63 (1991) 651-662.
7. Green G. L., Walter P., Kuma V., Krust A., Bornert J. M., Argos P. and Chambon P., Human estrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature 320 (1986) 134-139.
8. Hill S. M., Fuqua S. A. W., Charmness G. C. C., Greene G. L. and McGuire W. L., Estrogen receptor expression in human breast cancer associated with an estrogen receptor gene restriction fragment length polymorphism. Cancer Research 52 (1989) 77-83.
9. Ottaviano Y. L., Issa J. P., Pari F. F., Smith H. S. and Baylin S. B., Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells. Cancer Research 54 (1994) 2552-2555.
10. McGuire W. L., Charmness G. C. and Fuqua S. A. W., Estrogen receptor variants in clinical breast cancer. Molecular Endocrinology 5 (1991) 1571-1577.
11. Jiang S. Y., Langan-Fahey S. M., Stella A. L., McCague R. Jordan V. C., Point mutation of estrogen receptor (ER) in ligand-binding domain changes the pharmacology of antiestrogens in ER-negative breast cancer cells stably expressing complementary DNAs for ER. Molecular Endocrinology 6 (1992) 2167-2174.
12. Fuqua S. A. W., Fitzgerald S. D., Chamness G. C., Tondon A. K., McDonell D. P., Nawaz Z., O'Malley B. W. and Maguire W. L., Variant human breast tumor estrogen receptor with constitutive transcriptional activity. Cancer Research 51 (1991) 105-109.
13. Daffada A. A. I., Johnston S. R. D., Nicholls J. and Dowsett M., Detection of wild type and exon deleted splice variant estrogen receptor (ER) mRNA in ER-positive and -negative breast cancer cell lines by reverse transcription/polymerase chain reaction. Journal of Molecular Endocrinology 13 (1994) 265-273.
14. Daffada A. A. I. and Dowsett M., Tissue-dependent expression of a novel splice variant of the human receptor. Journal of Steroid Biochemistry and Molecular Biology 55 (1995) 413-421.
15. Pfeffer U., Fecarotta E. and Vidali G., Coexpression of multiple estrogen receptor variant messenger RNAs in normal and neoplastic breast tissues and in MCF-7 cells. Cancer Research 55 (1995) 2158-2165.
16. Gotteland M., Desauty G., Delarue J. C., Liu L. and May E., Human estrogen receptor messenger RNA variants in both normal and tumor breast tissues. Molecular and Cellular Endocrinology 112 (1995) 1-13.
17. Villa E., Camelli L., Dugani A., Zucchi F., Grottola A., Merighi A., Buttafoco P., Losi L. and Manenti F., Variant estrogen receptor messenger RNA species detected in human primary hepatocellular carcinoma. Cancer Research 55 (1995) 498-500.
18. Leygue E. R., Watson P. H. and Murphy L. C., Estrogen receptor variants in normal human mammary tissue. Journal of the National Cancer Institute 88 (1996) 284-290.
19. Koehorst S. G. A., Jacobs H. M., Thijssen J. H. H. and Blankenstein M. A., Wild type and alternatively spliced estrogen receptor messenger RNA in human meningioma tissue and MCF-7 breast cancer cells. Journal of Steroid Biochemistry and Molecular Biology 45 (1993) 227-233.
20. Koehorst S. G. A., Cox J. J., Donker G. H., Lopes da Silva S., Thijssen J. H. H. and Blankenstein M. A., Functional analysis of an alternatively spliced estrogen receptor lacking exon 4 isolated from MCF-7 breast cancer cells and meningioma tissue. Molecular and Cellular Endocrinology 101 (1994) 237-245.
21. Wang Y. and Miksicek R. J., Identification of a dominant negative form of the human estrogen receptor. Molecular Endocrinology 5 (1991) 1707-1715.
22. Fuqua S. A. W., Fitzgerald S. D., Allred D. C., Elledge R. M., Nawaz Z., McDonnell D. P., O'Malley B. W., Greene G. L. McGuire W. L., Inhibition of estrogen action by a naturally occurring variant in human breast tumors. Cancer Research 52 (1992) 483-486.
23. Fuqua S. A. W. and Wolf D., Molecular aspects of estrogen receptor variants in breast cancer. Breast Cancer Research Treatment 35 (1995) 233-241.
24. Daffada A. A. I., Johnston S. R. D., Smith I. E., Detre S., King N. and Dowsett M., Exon 5 deletion variant estrogen receptor messenger RNA expression in relation to tamoxifen resistance and progesterone receptor/pS2 status. Cancer Research 55 (1995) 288-293.
25. Bebbington C., Expression of antibody genes in nonlymphoid mammalian genes. Methods: A Companion to Methods in Enzymology 2 (1991) 136-145.
26. Sambrook, J., Maniatis, T. and Fritsch, E. F. (1989) Molecular Cloning: A Laboratory Manual, 2nd edn, Vol. 3, pp. 16.63-16.67. Cold Spring Harbor Laboratory Press, New York.
27. Greene G. L., Gilna P., Waterfield M., Baker A., Hort Y. and Shine J., Sequence and expression of human estrogen receptor complementary DNA. Science 231 (1986) 1150-1154.
28. Ermak G., Jennings T., Robinson L., Ross J. S. and Figge J., Restricted patterns of CD44 variant exon expression in human papillary thyroid carcinoma. Cancer Research 56 (1996) 1037-1042.
29. Chambraud B., Berry M., Redeuilh G., Chambon P. and Baulieu E. E., Several region of human estrogen receptor are involved in the formation of receptor-heat shock protein 90 complexes. Journal of Biological Chemistry 265 (1990) 20686-20691.
30. Edwards D. P., Chamness G. C. and McGuire W. L., Estrogen and progesterone receptors in breast cancer. Biochimica et Biophysica Acta 560 (1979) 457-486.
31. Rea D, and Parker M. G., Effects of an exon 5 variant of the estrogen receptor in MCF-7 breast cancer cells. Cancer Research 55 (1996) 1556-1563.