Inhibition of protein phosphatase 1 induces apoptosis in neonatal rat cardiac myocytes: Role of adrenergic receptor stimulation

Basic Research in Cardiology

Volumn 95, Issue 5, 2000, Pages 389-396

  Singh, Krishna ^a   Communal, Catherine ^a   Colucci, Wilson S ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Myocytes; Okadaic acid; Phosphorylation

Indexed keywords

ADENYLATE CYCLASE; ALPHA 1 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; CASPASE 3; CHEL; CHELERETHRINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DEPENDENT PROTEIN KINASE; DNA FRAGMENT; FORSKOLIN; KT 5823; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; NORADRENALIN; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; PRAZOSIN; PROPRANOLOL; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; UNCLASSIFIED DRUG;

ADHERENT CELL; ADRENERGIC STIMULATION; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL FUNCTION; CONCENTRATION RESPONSE; DEPHOSPHORYLATION; DRUG ANTAGONISM; DRUG INHIBITION; DRUG POTENTIATION; ENZYME ACTIVITY; ENZYME INHIBITION; HEART MUSCLE CELL; NEWBORN; NONHUMAN; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC GMP-DEPENDENT PROTEIN KINASES; ENZYME INHIBITORS; HEART; MYOCARDIUM; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE C; RATS; RECEPTORS, ADRENERGIC;

EID: 0033793442     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003950070038     Document Type: Article

References (47)

1. Apoptosis in pressure overload-induced heart hypertrophy in rat
2. Increased cardiac myocyte apoptosis during transition to heart failure in spontaneously hypertensive rat
3. Programmed myocyte cell death affects the viable myocardium after infarction in rat
4. Apoptosis in failing human heart
5. Acute myocardial infarction in humans is associated with the activation of programmed myocyte cell death in the surviving portion of heart
6. Apoptosis in myocytes in end-stage heart failure
7. Norepinephrine stimulates apoptosis in adult rat ventricular myocytes by activation of the b-adrenergic pathway
8. α- and β-adrenergic pathways differentially regulate cell type-specific apoptosis in rat cardiac myocytes
9. Angiotensin II induces apoptosis of adult ventricular myocytes in vitro
10. Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death
11. Atrial natriuretic peptide induces apoptosis in neonatal rat cardiac myocytes in vitro
12. The neurohormonal hypothesis: A theory to explain the mechanism of disease progression in heart failure
13. Plasma norepinephrine, plasma renin activity and congestive heart failure. Relations to survival and the effects of therapy in V-HeFT II: The V-HeFT VA Cooperative Studies Group
14. Inhibition of apoptosis in human tumour cells by okadaic acid
15. Down-regulation of c-myc and Max genes is associated to inhibition of protein phosphatase 2A in K562 human leukemia cells
16. Apoptosis of spodoptera frugiperda cells induced by okadaic acid is abrogated by baculovirus infection
17. T cell apoptosis induced by interleukin-2 deprivation or transforming growth factor-2: Modulation by the phosphatase inhibitors okadaic acid and calyculin A
18. Role of protein phosphorylation in TNF-induced apoptosis: Phosphatase inhibitors synergize with TNF to activate DNA fragmentation in normal as well as TNF-resistant U937 variants
19. Specific protein dephosphorylation in apoptosis induced by ionizing radiation and heat shock in human lymphoid tumor lines
20. Calyculin A, a potent inhibitor of phosphatases-1 and -2A, prevents apoptosis
21. Okadaic acid inhibits glucocorticoid-induced apoptosis in T cell hybridomas at its late stage
22. The involvement of protein phosphatases in the activation of ICE/CED-3 protease, intracellular acidification, DNA digestion and apoptosis
23. Evidence for physiological functions of protein phosphatases in the heart: Evaluation with okadaic acid
24. Autonomic regulation of type 1 protein phosphatase in cardiac muscle
25. Increased expression of cardiac phosphatases in patients with endstage heart failure
26. Electromechanical effects of okadaic acid isolated from black sponge in guinea pig ventricular muscles
27. Okadaic acid, a protein phosphatase inhibitor, increases the calcium transients in isolated ferret ventricular muscle
28. Effects of a protein phosphatase inhibitor, okadaic acid, on membrane currents of isolated guinea pig cardiac myocytes
29. Quantification of apoptotic events in pure and heterogenous populations of cells using the flow cytometer
30. Cytometry in cell necrobiology: Analysis of apoptosis and accidental cell death (necrosis)
31. Involvement of phosphorylation in doxorubicin-mediated myofibril degeneration. An immuno-fluorescence microscopy analysis
32. K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases
33. Nitric oxide-induced apoptosis in RAW 264.7 macrophages is antagonized by protein kinase C- and protein kinase A-activating compounds
34. Opposing effects of b1-and b2-adrenergic receptors on cardiac myocyte apoptosis: Role of a pertussis toxin-sensitive G protein
35. Protein kinase C-dependent activation of cytosolic phospholipase A2 and mitogen-activated protein kinase by alpha 1-adrenergic receptors in Madin-Darby canine kidney cells
36. Adrenergic receptor stimulation of the mitogen-activated protein kinase cascade and cardiac hypertrophy
37. Activation of protein kinase C attenuates early signals in Fas-mediated apoptosis
38. Activation of a suicide process of thymocytes through DNA fragmentation by calcium ionophores and phorbol esters
39. Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway. Divergence from downstream CT-1 signals for myocardial cell hypertrophy
40. Ultrarapid caspase-3 dependent apoptosis induction by serine/threonine phosphatase inhibitors
41. The temporal relationship between protein phosphatase, mitochondrial cytochrome c release, and caspase activation in apoptosis
42. Regulation of cell death protease caspase-9 by phosphorylation
43. Inhibition of forskolin-induced neurite out-growth and protein phosphorylation be a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocin-namylamino)ethyl]-5-isoquinoline sulfonamide (H-89), of PC12 pheochromocytoma cells
44. Basic mechanisms and implications for cardiovascular disease
45. β-adrenergic stimulation causes cardiocyte apoptosis: Influence of tachycardia and hypertrophy
46. Tumor necrosis factor induces phosphorylation and translocation of BAD through a phosphatidylinositide-3-OH kinase-dependent pathway