The CTLA4/CD28 gene region on chromosome 2q33 confers susceptibility to celiac disease in a way possibly distinct from that of type 1 diabetes and other chronic inflammatory disorders

Tissue Antigens

Volumn 56, Issue 4, 2000, Pages 350-355

  Naluai, Å Torinsson ^a,e   Nilsson, S ^b   Samuelsson, L ^a   Gudjonsdottir A H ^a   Ascher, H ^a   Ek, J ^d   Hallberg, B ^a   Kristiansson, B ^a   Martinsson, T ^a   Nerman, O ^b   Sollid, L M ^c   Wahlstrom J ^a  

^a QUEEN SILVIA CHILDREN'S HOSPITAL   (Sweden)

^b CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

^c UNIVERSITY OF OSLO   (Norway)

^d Buskerud Central Hospital   (Norway)

^e SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Celiac disease; CTLA4; Genetic study; IDDM; Linkage analysis; Transmission disequilibrium test

Indexed keywords

CD28 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4;

ARTICLE; CELIAC DISEASE; CHROMOSOME 2Q; DNA POLYMORPHISM; EXON; FAMILY STUDY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENOTYPE; GRAVES DISEASE; HUMAN; INFLAMMATORY DISEASE; INSULIN DEPENDENT DIABETES MELLITUS; MULTIPLE SCLEROSIS; NORWAY; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SWEDEN;

ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, DIFFERENTIATION; CELIAC DISEASE; CHROMOSOMES, HUMAN, PAIR 2; CHRONIC DISEASE; DIABETES MELLITUS, TYPE 1; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNOCONJUGATES; INFLAMMATION; MALE;

EID: 0033792862     PISSN: 00012815     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-0039.2000.560407.x     Document Type: Article

References (45)

1. Molecular basis of celiac disease
2. The role of quantity and quality of gluten-containing cereals in the epidemiology of coeliac disease
3. Increasing incidence of coeliac disease in Sweden
4. Increasing incidence of childhood coeliac disease in Sweden. Results of a national study
5. Epidemic of coeliac disease in Swedish children
6. HLA susceptibility genes in celiac disease: Genetic mapping and role in pathogenesis
7. Assessing the role of HLA-linked and unlinked determinants of disease
8. Genetic contribution of the HLA region to the familial clustering of coeliac disease
9. An autosomal screen for genes that predispose to celiac disease in the western counties of Ireland
10. Genome search in celiac disease
11. Linkage analysis of candidate regions for coeliac disease genes
12. A pedigree-based linkage study of coeliac disease: Failure to replicate previous positive findings
13. CD28/CTLA4 gene region on chromosome 2q33 confers genetic susceptibility to celiac disease. A linkage and family-based association study
14. CTLA-4 gene polymorphism is associated with predisposition to coeliac disease
15. Linkage and association study of the CTLA-4 region in coeliac disease for Italian and Tunisian populations
16. Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups
17. The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry
18. Analysis of candidate genes for susceptibility to type I diabetes: A case-control and family-association study of genes on chromosome 2q31-35
19. Non-HLA genes and the susceptibility to insulin dependent diabetes: The role of the CTLA-4 gene
20. Association of CTLA-4 gene A-G polymorphism (IDDM12 locus) with acute-onset and insulin-depleted IDDM as well as autoimmune thyroid disease (Graves' disease and Hashimoto's thyroiditis) in the Japanese population
21. CTLA4 gene haplotypes cannot protect from IDDM in the presence of high-risk HLA DQ8 or DQ2 alleles in German families
22. No major role for the CTLA-4 gene in the association of autoimmune thyroid disease with IDDM
23. No evidence for allelic association of a human CTLA-4 promoter polymorphism with autoimmune thyroid disease in either population-based case-control or family-based studies
24. Association of autoimmune thyroid disease with a microsatellite marker for the thyrotropin receptor gene and CTLA-4 in a Japanese population
25. CTLA-4 promoter variants in patients with Graves' disease and Hashimoto's thyroiditis
26. CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus
27. The development of Graves' disease and the CTLA-4 gene on chromosome 2q33
28. CTLA-4 gene polymorphism associated with Graves' disease in a Caucasian population
29. CTLA4 gene polymorphism confers susceptibility to Graves' disease in Japanese
30. A CTLA-4 gene polymorphism is associated with both Graves disease and autoimmune hypothyroidism
31. CTLA4 polymorphisms in Spanish patients with rheumatoid arthritis
32. CTLA4 codon 17 dimorphism in patients with rheumatoid arthritis
33. CTLA4 promoter and exon 1 dimorphisms in multiple sclerosis
34. The CTLA-4 gene is associated with multiple sclerosis
35. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
36. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
37. Blockage of T-cell costimulation inhibits T-cell action in celiac disease
38. Revised criteria for diagnosis of coeliac disease. Report of working group of European Society of Paediatric Gastroenterology and Nutrition
39. An Mse I RFLP in the human CTLA4 promotor
40. Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM)
41. An extended transmission/disequilibrium test (TDT) for multi-allele marker loci
42. Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease. SIGEP Study Group for Autoimmune Disorders in Celiac Disease
43. Celiac disease and autoimmune endocrinologic disorders
44. A yeast artificial chromosome-based physical map of the juvenile amyotrophic lateral sclerosis (ALS2) critical region on human chromosome 2q33-q34
45. A comprehensive genetic map of the human genome based on 5,264 microsatellites