A pedigree-based linkage study of coeliac disease: Failure to replicate previous positive findings

Annals of Human Genetics

Volumn 62, Issue 1, 1998, Pages 25-32

  Brett, P M ^c   Yiannakou, J Y ^a   Morris, M A ^a   Rosen Bronson, S ^d   Mathew, C ^a   Curtis, D ^b   Ciclitira, P J ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA DQ ANTIGEN;

ARTICLE; CELIAC DISEASE; CIS TRANS ISOMERISM; EUROPE; GENETIC LINKAGE; GENETIC PREDISPOSITION; GENOTYPE; GREECE; HUMAN; ISRAEL; JEW; PEDIGREE; PRIORITY JOURNAL;

CELIAC DISEASE; COHORT STUDIES; FEMALE; GENETIC HETEROGENEITY; GENETIC PREDISPOSITION TO DISEASE; HLA ANTIGENS; HUMANS; LOD SCORE; MALE; MICROSATELLITE REPEATS; PEDIGREE;

EID: 0031823426     PISSN: 00034800     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0003480098006642     Document Type: Article

References (21)

1. BRETT, P. M., YIANNAKOU, J. Y., MORRIS, M.-A., VAUGHAN, R., ROSEN-BROSON, S., CURTIS, D. & CICLITIRA, P. J. (1996). Evidence for the involvement of a non-HLA susceptibility gene in the genetic aetiology of coeliac disease. American Journal of Human Genetics 59(s), A214.
2. CORRAO, G., CORAZZA, G. R., ANDREASI, M. L., TORCHIO, P., VALENTINI, R. A. & GALATOLA, G. et al. (1994). Serological screening of coeliac disease : choosing the optimal procedure according to various prevalence values. Gut 35, 771-775.
3. CURTIS, D. & SHAM, P.C. (1995). Model-free linkage analysis using likelihoods. American Journal of Human Genetics 57, 703-716.
4. CURTIS, D. & SHAM, P.C. (1996). Population stratifications can cause false positive linkage results if founders are untyped. Annals of Human Genetics 60, 261-263.
5. ELLIS, A. (1981). Coeliac disease: previous family studies. In: The genetics of coeliac disease (ed R. B. McConnel), pp. 197-200. Lancaster, UK: MTP.
6. GREENBERG, D. A. & LANGE, K. L. (1982). A maximum likelihood test of the two locus model for coeliac disease Am. J. Med. Gen. 12, 75-82
7. HOULSTON, R. S. & FORD, D. (1996). Genetics of coeliac disease. Q. J. Med. 89, 737-743.
8. LATHKOP, G. M. & LALOUEL, J. M. (1984). Easy calculation of lod scores and genetic risks on small computers. American Journal of Genetics 36, 460-465.
9. MAKI, M., HOLM, K., LIPSANEN, V., HOLLSTROM. O., VIANDER, M., COLLIN, P., SAVILAHTI, E. & KOSKIMIES, S. (1991). Serological markers and HLA genes among healthy first-degree relatives of patients with coeliac disease. Lancet 338, 1350-1353.
10. MARSH, M. N. (1992). Gluten, major histocompatibility complex and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('coeliac sprue'). Gastroenterology 102, 330-354
11. O'CONNELL, J. & WEEKS, D. E. (1995). The VITESSE algorithm for rapid exact multiloeus linkage analysis via genotype set-recoding and fuzzy inheritance. Nature Genetics 11, 402-408.
12. OLERUP, O., ALDENER, A. & FOGDELL, A. (1993). HLA-DQ 1 and DQ1 typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2, hours. Tissue Antigens. 41, 119-134.
13. PENA, A. S., MANN, D. L., HAGUE, N. E., HECK, J. A., LEEUWEN, A. V., VAN ROOD, J. J. & STROBER, W. (1978). Genetic basis of gluten-sensitive enteropathy. Gastroenterology 75, 230-235.
14. POLANKO, L. BIEMOND, I., VAN LEEUWEN, A., SCHREUDER, I., KAHN, P. M., GUERRERO, J., D'AMARO, J. VASQUEZ, C., VAN ROOD, J. J. & PENA, A. S. (1981). Gluten sensitive enteropathy in Spain : genetic and environmental factors. In : The genetics of coeliac disease (ed. R. B. McConnel). pp.211-231. Lancaster, UK: MTP.
15. SALAZAR DE SOUZA, J., RAMOS DE ALMEIDA, J. M., MONTEIRO, M. V. & MAGALHAES RAMALHO, P. (1987). Late onset coeliac disease in the monozygotic twin of a coeliac child. Acta Paediatrica Scandinavica 76, 172-174.
16. SOLLID, L. M. & THORSBY, E. (1993). HLA susceptibility genes in celiac disease : Genetic mapping and role in pathogenesis. Gastroenterology 105, 910-922.
17. TIGHE, M. R., HALL, M. A., BABBADO, M., CARDI, E., WELSH, K. I. & CICLITIRA, P. J. (1992). HLA-class II alleles associated with coeliac disease susceptibility in a Southern European population. Tissue Antigens 40, 90-97.
18. TIGHE, M. R., HALL, M. A., ASHKENAZI, A., SIEGLER, E., LANCHBURY, J. S. & CICLITIRA, P. J. (1993). Coeliac disease among Ashkenazi Jews from Israel : a study of the HLA-class II alleles and their association with disease susceptibility. Human Immunology 38, 270-276.
19. WALKER-SMITH, J. A., GUANDALINI, S., SCHMITZ. J., SHIMERLING, D. H. & VISAKORPI, J. K. (1990). Revised criteria for the diagnosis of coeliac disease. Arch. Dis. Child. 65, 909-911.
20. YIANNAKOU, J. Y., DELL'OLIO, D., SAAKA, M., ELLIS, H. J., ROSEN-BRONSON, S., DUMONDE, D. C. & CICLITIKA, P. J. (1997), Detection and characterisation of anti-endomysial antibody in coeliac disease using human umbilical cord. Arch. Int. All. & Immunol. 112, 140-144.
21. ZHONG, F., MCCOMBS, C. C., OLSON, J. M., ELSTON, R. C., STEVENS, F. M., MCCARTHY, C. F. & MICHALSKI, J. P. (1996). An autosomal screen for genes that predispose to celiac disease in the western counties of Ireland. Nature Genetics 14, 329-333.