No evidence for allelic association of a human CTLA-4 promoter polymorphism with autoimmune thyroid disease in either population-based case- control or family-based studies

Clinical Endocrinology

Volumn 49, Issue 3, 1998, Pages 331-334

  Heward, J M ^a   Allahabadia, A ^a   Carr Smith, J ^a   Daykin, J ^a   Cockram, C S ^c   Gordon, C ^d   Barnett, A H ^a,b   Franklyn, J A ^a   Gough, S C L ^a,b  

^a UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

^b BIRMINGHAM HEARTLANDS HOSPITAL   (United Kingdom)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DNA;

ALLELE; ARTICLE; AUTOIMMUNE DISEASE; CASE CONTROL STUDY; CAUCASIAN; CHINESE; CONTROLLED STUDY; FAMILY STUDY; GENETIC POLYMORPHISM; GRAVES DISEASE; HONG KONG; HUMAN; HYPOTHYROIDISM; MAJOR CLINICAL STUDY; POPULATION RESEARCH; PRIORITY JOURNAL; PROMOTER REGION; SYSTEMIC LUPUS ERYTHEMATOSUS; UNITED KINGDOM;

ALLELES; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; AUTOIMMUNE DISEASES; CASE-CONTROL STUDIES; CHINA; GENOTYPE; GRAVES DISEASE; HONG KONG; HUMANS; HYPOTHYROIDISM; IMMUNOCONJUGATES; LUPUS ERYTHEMATOSUS, SYSTEMIC; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); THYROID DISEASES;

EID: 0031721837     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.1998.00542.x     Document Type: Article

References (16)

1. Awata, T., Kurihara, S., Iitaka, M., Takei, S.-I., Inoue, I., Ishii, C., Negishi, K., Izumida, T., Yoshida, Y., Hagura, R., Kuzuya, N., Kanazawa, Y. & Katayama, S. (1998) Association of CTLA-4 gene A-G polymorphism (IDDM12 locus) with acute-onset and insulin-depleted IDDM as well as autoimmune thyroid disease (Graves' disease and Hashimoto's thyroiditis) in the Japanese population. Diabetes, 47, 128-129.
2. Bluestone, J.A. (1997) Is CTLA4 a master switch for peripheral T cell tolerance? Journal of Immunology, 158, 1989-1993.
3. Deichmann, K., Heinzmann, A., Bruggenolte, E., Forster, J. & Kuehr, J. (1996) An Mse I RFLP in the human CTLA4 promoter. Biochemical and Biophysical Research Communications, 225, 817-818.
4. Djilali-Saiah, I., Larger, E., Harfouch-Hammoud, E., Timsit, J., Clerc, J., Bertin, E., Assan, R., Boitard, C., Bach, J.-F. & Caillat-Zucman, S. (1998) No major role for the CTLA-4 gene in the association of autoimmune thyroid disease with IDDM. Diabetes, 47, 125-127.
5. Donner, H., Rau, H., Walfish, P.G., Braun, J., Siegmund, T., Finke, R., Herwig, J., Usadel, K.H. & Badenhoop, K. (1997a) CTLA4 Alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus. Journal of Clinical Endocrinology and Metabolism, 82, 143-146.
6. Donner, H., Braun, J., Seidl, C., Rau, H., Finke, R., Ventz, M., Walfish, P.G., Usadel, K.H. & Badenhoop, K. (1997b) Codon 17 polymorphism of the cytotoxic T lymphocyte antigen 4 gene in Hashimoto's thyroiditis and Addison's disease. Journal of Clinical Endocrinology and Metabolism, 82, 4130-4132.
7. Gough, S.C.L., Saker, P.J., Pritchard, L.E., Merriman, T.T., Merriman, M.E., Rowe, B.R., Kumar, S., Aitman, T., Barnett, A.H., Turner, R.C., Bain, S.C. & Todd, J.A. (1995) Mutation of the glucagon receptor gene and diabetes mellitus in the UK: association or founder effect? Human Molecular Genetics, 4, 1609-1612.
8. Heward, J.M. & Gough, S.C.L. (1997) Genetic susceptibility to the development of autoimmune disease. Clinical Science, 93, 479-491.
9. Kotsa, K., Watson, P.F. & Weetman, A.P. (1997) A CTLA-4 gene polymorphism is associated with both Graves' disease and autoimmune hypothyroidism. Clinical Endocrinology, 46, 551-554.
10. Lander, E.S. & Schork, N.J. (1994) Genetic dissection of complex traits. Science, 265, 2037-2048.
11. Marron, M.P., Raffel, L.J., Garchon, H.-J., Jacob, C.O., Serrano-Rios, M., Martinez Larrad, M.T., Teng, W.-P., Park, Y., Zhang, Z.-X., Goldstein, D.R., Tao, Y.-W., Beaurain, G., Bach, J.-F., Huang, H.-S., Luo, D.-F., Zeidler, A., Rotter, J.I., Yang, M.C.K., Modilevsky, T., Maclaren, N.K. & She, J.-X. (1997) Insulin dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups. Human Molecular Genetics, 6, 1275-1282.
12. Nistico, L., Buzzetti, R., Pritchard, L.E., Van der Auwera, B., Giovannini, C., Bosi, E., Martinez Larrad, M.T., Serrano-Rios, M., Chow, C.C., Cockram, C.S., Jacobs, K., Mijovic, C., Bain, S.C., Barnett, A.H., Vandewalle, C.L., Schuit, F., Gorus, F.K., Belgian Diabetes Registry, T.o.s.i., R., Pozzilli, P. & Todd, J.A. (1996) The CTLA4 region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Human Molecular Genetics, 5, 1075-1089.
13. Spielman, R.S., McGinnis, R.E. & Ewens, W.J. (1993) Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). American Journal of Human Genetics, 52, 506-516.
14. Tan, E.M., Cohen, A.S. & Fries, J.F. (1982) The 1982 revised criteria for the classification of systemic lupus erythematosus (SLE). Arthritis and Rheumatism, 25, 1271-1277.
15. Yanagawa, T., Hidaka, Y., Guimares, V., Soliman, M. & DeGroot, L.J. (1995) CTLA4 gene polymorphism associated with Graves' disease in a Caucasian population. Journal of Clinical Endocrinology and Metabolism, 80, 41-45.
16. Yanagawa, T., Taniyama, M., Enomoto, S., Gomi, K., Maruyama, H., Ban, Y. & Saruta, T. (1997) CTLA4 gene polymorphism confers susceptibility to Graves' disease in Japanese. Thyroid, 7, 843-846.