Development of a new genotoxicity test system with Salmonella typhimurium OY1001/1A2 expressing human CYP1A2 and NADPH-P450 reductase

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 442, Issue 2, 1999, Pages 113-120

  Aryal, Pramod ^a,b   Yoshikawa, Kentaro ^b   Terashita, Takao ^b   Guengerich, F Peter ^c   Shimada, Tsutomu ^a   Oda, Yoshimitsu ^a  

^a OSAKA PREFECTURAL INSTITUTE OF PUBLIC HEALTH   (Japan)

^b KINKI UNIVERSITY   (Japan)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aromatic amine; Cytochrome P450 1A2; Genotoxicity; umu test

Indexed keywords

2 AMINO 3 METHYLIMIDAZO[4,5 F]QUINOLINE; 2 AMINO 3,4 DIMETHYLIMIDAZO[4,5 F]QUINOLINE; 2 AMINO 3,8 DIMETHYLIMIDAZO[4,5 F]QUINOXALINE; 2 AMINO 6 METHYLDIPYRIDO[1,2 A:3',2' D]IMIDAZOLE; 2 AMINOANTHRACENE; AROMATIC AMINE; CYTOCHROME P450 ISOENZYME; HETEROCYCLIC AMINE; ISOPROPYL THIOGALACTOSIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE;

ARTICLE; GENOTOXICITY; METABOLIC ACTIVATION; MUTAGEN TESTING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SALMONELLA TYPHIMURIUM;

AMINES; CYTOCHROME P-450 CYP1A2; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDROCARBONS, AROMATIC; ISOQUINOLINES; MUTAGENICITY TESTS; MUTAGENS; NADPH-FERRIHEMOPROTEIN REDUCTASE; PLASMIDS; QUINOLINES; QUINOXALINES; SALMONELLA TYPHIMURIUM;

EID: 0032967962     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(99)00070-4     Document Type: Article

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