The effect of concentrated n-3 fatty acids versus gemfibrozil on plasma lipoproteins, low density lipoprotein heterogeneity and oxidizability in patients with hypertrygliceridemia

Atherosclerosis

Volumn 153, Issue 1, 2000, Pages 129-138

  Stalenhoef, Anton F H ^a   De Graaf, Jacqueline ^a   Wittekoek, Marianne E ^b   Bredie, Sebastian J H ^a   Demacker, Pierre N M ^a   Kastelein, John J P ^b  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Fish oil; Gemfibrozil; Hypertriglyceridemia; Low density lipoprotein oxidation; Low density lipoprotein subfractions; Omega 3 fatty acids

Indexed keywords

ALKADIENE; CONJUGATED DIENE; DOCOSAHEXAENOIC ACID; GEMFIBROZIL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; ICOSAPENTAENOIC ACID; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OMEGA 3 FATTY ACID; OXIDIZED LOW DENSITY LIPOPROTEIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; ARTICLE; CARDIOVASCULAR DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FRACTIONATION; HUMAN; HYPERTRIGLYCERIDEMIA; LIPOPROTEIN BLOOD LEVEL; MULTICENTER STUDY; OXIDATION; PRIORITY JOURNAL; PROTEIN MODIFICATION; RANDOMIZED CONTROLLED TRIAL; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; ANTILIPEMIC AGENTS; DOUBLE-BLIND METHOD; FATTY ACIDS; FATTY ACIDS, OMEGA-3; GEMFIBROZIL; HUMANS; HYPERTRIGLYCERIDEMIA; LIPIDS; LIPOPROTEINS; LIPOPROTEINS, LDL; MIDDLE AGED; OSMOLAR CONCENTRATION; OXIDATION-REDUCTION; VITAMIN E;

EID: 0033789411     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(00)00381-6     Document Type: Article

References (53)

1. The triglyceride issue: A view from Framingham
2. Defective metabolism of hypertriglyceridemic low density lipoprotein in cultured human skin fibroblasts
3. Abnormal regulation of LDL receptor activity and abnormal cellular metabolism of hypertriglyceridaemic low density lipoprotein: normalization with bezafibrate
4. Identification of multiple dense LDL subfractions with enhanced susceptibility to in vitro oxidation among hypertriglyceridemic subjects. Normalization after clofibrate treatment
5. Abnormalities in very low, low and high density lipoproteins in hypertriglyceridemia. Reversal toward normal with bezafibrate treatment
6. Low density lipoprotein subfractions and relationship to other risk factors for coronary artery disease in healthy individuals
7. Low density lipoprotein subclass patterns and risk of myocardial infarction
8. Low density lipoprotein particle size and coronary heart disease
9. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity
10. N-3 fatty acids and serum lipoproteins: human studies
11. Dietary fish oil and blood lipids
12. Fibric acids: effects on lipids and lipoprotein metabolism
13. Mechanism of action of fibrates
14. Effects of fish oil fatty acids on low density lipoprotein size, oxidizability and uptake by macrophages
15. Effect of pravastatin and w-3 fatty acids on plasma lipids and lipoproteins in patients with combined hyperlipidemia
16. Effect of dietary supplementation with n-3 polyunsaturated fatty acids on physical properties and metabolism of low density lipoprotein in humans
17. Comparison of gemfibrozil versus simvastatin in familial combined hyperlipidemia and effects on apolipoprotein-B-containing lipoproteins, low-density lipoprotein subfraction profile and low density lipoprotein oxidizability
18. Effects of fish oil on oxidation resistance of VLDL in hypertriglyceridemic patients
19. Influence of probucol on enhanced LDL oxidation after fish oil treatment of hypertriglyceridemic patients
20. Fish oil ingestion in smokers and non-smokers enhances peroxidation of plasma lipoproteins
21. Peroxidation of LDL from combined-hyperlipidemic male smokers supplied with omega-3 fatty acids and antioxidants
22. Effect of n-3 fatty acid-rich fish oil supplementation on the oxidation of low density lipoproteins
23. Dietary polyunsaturates and peroxidation of low density lipoprotein
24. Hypolipidemic drugs reduce lipoprotein susceptibility to undergo lipid peroxidation: in vitro and ex vivo studies
25. Precipitation methods for high-density lipoprotein cholesterol measurement compared, and final evaluation under routine operating conditions of a method with a low sample-to-reagent ratio
26. Type III hyperlipoproteinemia: development of a VLDL apoE gel isoelectric focusing technique and application in family studies
27. Single spin density gradient ultracentrifugation method for the detection and isolation of light and heavy low density lipoprotein subfractions
28. Inherited susceptibility determines the distribution of dense low density lipoprotein subfraction profiles in familial combined hyperlipidemia
29. Both inherited susceptibility and environmental exposure determine the low denstiy lipoprotein subfraction pattern distribution in healthy Dutch families
30. Protein measurement with the Folin phenol reagent
31. Continuous monitoring of in vitro oxidation of human low density lipoprotein
32. Improved measurement of low-density-lipoprotein susceptibility to copper-induced oxidation: application of a short procedure for isolating low-density lipoprotein
33. Enhanced susceptibility to in vitro oxidation of the dense low density lipoprotein subfraction in healthy subjects
34. Improved fluorimetric determination of malonaldehyde
35. Improved direct determination of alpha- and gamma-tocopherols in plasma and platelets by liquid chromatography, with fluorescence detection
36. Modification of lipid-related atherosclerosis risk factors by omega-3 fatty acid ethyl esters in hypertriglyceridemic patients
37. Peroxisome proliferator-activated receptors: orphans with ligands and functions
38. Transcriptional control of triglyceride metabolism: fibrates change the expression of the LPL and apoCIII genes by activating the nuclear receptor PPAR
39. Role of the peroxisome proliferator activated receptor (PPAR) in mediating effect of fibrates and fatty acids on gene expression
40. Metabolism of VLDL and LDL subclasses
41. Plasma triglyceride determines structure-composition in low and high density lipoproteins
42. Low density lipoprotein rich in oleic acid is protected against oxidative modification: implications for dietary prevention of atherosclerosis
43. Effects of linoleate-enriched and oleate-enriched diets in combination with alpha-tocopherol on the susceptibility of LDL and LDL subfractions to oxidative modification in humans
44. Effects of oleate-rich and linoleate-rich diets on the susceptibility of low density lipoprotein to oxidative modification in mildly hypercholesterolemic subjects
45. Atorvastatin and gemfibrozil metabolites, but not the parent drugs, are potent antioxidants against lipoprotein oxidation
46. N-3 fatty acid incorporation into LDL particles renders them more susceptible to oxidation in vitro but not necessarily more atherogenic in vivo
47. Dietary fish oil-influence on lesion regression in the porcine model of atherosclerosis
48. Cardiovascular effects of n-3 fatty acids
49. Effects of dietary fish oil and omega-3 fatty acids on platelets and blood vessels
50. Polyunsaturated fatty acids and function of platelets and endothelial cells
51. Polyunsaturated fatty acids and platelet aggregation
52. Fish consumption, fish oil, lipids and coronary heart disease
53. Antiarrhythmic effects of polyunsaturated fatty acids