Bacterial vaccines for the treatment of multiple sclerosis and other autoimmune diseases

Immunology Today

Volumn 21, Issue 10, 2000, Pages 503-508

  Rook, Graham A W ^a   Ristori, Giovanni ^b   Salvetti, Marco ^b   Giovannoni, Gavin ^c   Thompson, Edward J ^c   Stanford, John L ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL VACCINE; CYTOKINE; GAMMA INTERFERON; HEAT SHOCK PROTEIN; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; MYCOBACTERIUM VACCINE; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; AUTOIMMUNE DISEASE; EFFECTOR CELL; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; REGULATORY MECHANISM; REVIEW; TH1 CELL; TH2 CELL;

EID: 0033787563     PISSN: 01675699     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-5699(00)01700-X     Document Type: Note

References (67)

1. Molecular mimicry and autoimmunity
2. Heat-shock proteins as immunogenic bacterial antigens with the potential to induce and regulate autoimmune arthritis
3. Th2 conditioning by Trichuris suis appears safe and effective in modifying the mucosal immune response in inflammatory bowel disease
4. Rate of pregnancy-related relapse in multiple sclerosis. Pregnancy in multiple sclerosis group
5. Inhibition of leukotriene B4-receptor interaction suppresses eosinophil infiltration and disease pathology in a murine model of experimental allergic encephalomyelitis
6. Multiple sclerosis: B- and T-cell responses to the extracellular domain of the myelin oligodendrocyte glycoprotein
7. Activated non-neural specific T cells open the blood-brain barrier to circulating antibodies
8. Antibody facilitation of multiple sclerosis-like lesions in a nonhuman primate
9. The role of TNF-α in T cell-mediated inflammation depends on the Th1/Th2 cytokine balance
10. IL-4-regulated enteropathy in an intestinal nematode infection
11. Impaired contact hypersensitivity to trinitrocholobenzene in interleukin-4-deficient mice
12. Interferon γ-1b for the treatment of idiopathic pulmonary fibrosis
13. Late complications of immune deviation therapy in a nonhuman primate
14. Mycobacteria precipitate an SLE-like syndrome in diabetes-prone NOD mice
15. Monoclonal antibody treatment exposes three mechanisms underlying the clinical course of multiple sclerosis
16. Pulsed monoclonal anti-body treatment and autoimmune thyroid disease in multiple sclerosis
17. Reciprocal control of T helper cell and dendritic cell differentiation
18. Lack of Th2 cytokine increase during spontaneous remission of experimental allergic encephalomyelitis
19. T helper cell subsets in insulin-dependent diabetes
20. Neuroantigen-specific Th2 cells are inefficient suppressors of experimental autoimmune encephalomyelitis induced by effector Th1 cells
21. + naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state
22. + immunoregulatory T cells suppress clonal T cell activation in vitro by inhibiting interleukin 2 production
23. Expansion of neonatal tolerance to self in adult life: I. The role of a bacterial adjuvant in tolerance spread
24. The third function of the thymus
25. Modulation of experimental autoimmunity: Treatment of adjuvant arthritis by immunization with a recombinant vaccinia virus
26. Protection of rats from adjuvant arthritis by immunization with naked DNA encoding for mycobacterial heat shock protein 65
27. Effect of adjuvant therapy on development of diabetes in mouse and man
28. Regulation of autoimmune diabetes: Characteristics of non-islet-antigen specific therapies
29. Endogenous immune response to glutamic acid decarboxylase (GAD67) in NOD mice is modulated by adjuvant immunotherapy
30. Vaccination with DNA encoding an immunodominant myelin basic protein peptide targeted to Fc of immunoglobulin G suppresses experimental autoimmune encephalomyelitis
31. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants
32. Presence of CpG DNA and the local cytokine milieu determine the efficacy of suppressive DNA vaccination in experimental autoimmune encephalomyelitis
33. Autoimmunity, microbial immunity and the immunological homunculus
34. + T cell subsets according to their expression of CD45 isotypes
35. The small heat-shock protein α B-crystallin as candidate autoantigen in multiple sclerosis
36. Do heat shock proteins control the balance of T-cell regulation in inflammatory diseases?
37. Give us this day our daily germs
38. Phylogenetic perspectives in innate immunity
39. Persisting viruses and chronic inflammation: Understanding their relation to autoimmunity
40. Chlamydia pneumoniae infection of the central nervous system in multiple sclerosis
41. Failure to detect Chlamydia pneumoniae in the central nervous system of patients with MS
42. The immune response to mycobacterial 70-kDa heat shock proteins frequently involves autoreactive T cells and is quantitatively disregulated in multiple sclerosis
43. γδ T cell receptor analysis supports a role for HSP 70 selection of lymphocytes in multiple sclerosis lesions
44. T-lymphocyte reactivity to the recombinant mycobacterial 65- and 70-kDa heat shock proteins in multiple sclerosis
45. High prevalence of anti α-crystallin antibodies in multiple sclerosis: Correlation with severity and activity of disease
46. Microbe exposure, innate immunity and autoimmunity
47. Measles history and atopic diseases: A population-based cross-sectional study
48. Exposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma; epidemiological study
49. Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitisation in infants at high risk of asthma
50. Reverse effect of Gram-positive bacteria vs. Gram-negative bacteria on adjuvant-induced arthritis in germfree rats
51. Heat shock proteins and experimental autoimmune encephalomyelitis. II: Environmental infection and extra-neuraxial inflammation alter the course of chronic relapsing encephalomyelitis
52. Treatment of multiple sclerosis with gamma interferon: Exacerbations associated with activation of the immune system
53. Transient increase in symptoms associated with cytokine release in patients with multiple sclerosis
54. Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-γ
55. Chronic relapsing experimental autoimmune encephalomyelitis (CREAE) in mice: Enhancement by monoclonal antibodies against interferon-gamma
56. IFN-γ plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis
57. Interferon β in multiple sclerosis; is IL-12 suppression the key?
58. Effects of interferon-alpha on cytokine profile, T cell receptor repertoire and peptide reactivity of human allergen-specific T cells
59. Human recombinant interferon-beta influences T helper subset differentiation by regulating cytokine secretion pattern and expression of homing receptors
60. Two roads diverged: Interferon alpha/beta-and interleukin 12-mediated pathways in promoting T cell interferon gamma responses during viral infection
61. T cell response to myelin basic protein before and after treatment with interferon β in multiple sclerosis
62. Use of bacille Calmette-Guerin (BCG) in multiple sclerosis
63. Variation in protection by BCG: Implications of and for heterologous immunity
64. Fortsetzung uber ein heilmittel gegen tuberculose
65. Immunotherapy with Mycobacterium vaccae in the treatment of psoriasis
66. Improvement in psoriasis after intradermal administration of heat-killed Mycobacterium vaccae