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Functional antagonism between RNA polymerase II holoenzyme and global negative regulator NC2 in vivo
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of special interest. The suppressor of RNA polymerase B (SRB) or mediator complex is tightly associated with the RNA polymerase II holoenzyme. A deficiency in yeast NC2 can compensate for the global transcriptional effects caused by mutations in the SRB4 and SRB6 subunits of RNA polymerase II holoenzyme. The authors suggest that NC2 might function as a global repressor on most, if not all, promoters.
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of special interest Gadbois EL, Chao DM, Reese JC, Green MR, Young RA. Functional antagonism between RNA polymerase II holoenzyme and global negative regulator NC2 in vivo. Proc Natl Acad Sci USA. 94:1997;3145-3150 The suppressor of RNA polymerase B (SRB) or mediator complex is tightly associated with the RNA polymerase II holoenzyme. A deficiency in yeast NC2 can compensate for the global transcriptional effects caused by mutations in the SRB4 and SRB6 subunits of RNA polymerase II holoenzyme. The authors suggest that NC2 might function as a global repressor on most, if not all, promoters.
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(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 3145-3150
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Gadbois, E.L.1
Chao, D.M.2
Reese, J.C.3
Green, M.R.4
Young, R.A.5
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56
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0027941699
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Structure-function analysis of the TBP-binding protein Dr1 reveals a mechanism for repression of class II gene transcription
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Yeung KC, Inostroza JA, Mermelstein FH, Kannabiran C, Reinberg D. Structure-function analysis of the TBP-binding protein Dr1 reveals a mechanism for repression of class II gene transcription. Genes Dev. 8:1994;2097-2109.
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(1994)
Genes Dev
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, pp. 2097-2109
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Yeung, K.C.1
Inostroza, J.A.2
Mermelstein, F.H.3
Kannabiran, C.4
Reinberg, D.5
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