Receptor activator of NF-κB ligand induces the fusion of mononuclear preosteoclasts into multinucleated osteoclasts

Cytotechnology

Volumn 33, Issue 1-3, 2000, Pages 203-211

  Woo, Je Tae ^a   Kato, Masanori ^a   Takami, Masamichi ^a   Nagai, Kazuo ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Fusion; IL 1 ; NF B; Osteoclast; RANKL

Indexed keywords

CELL DIFFERENTIATION; CELL FUSION; CELL SURVIVAL; CULTURE VESSEL; GENE ACTIVATION; GENETIC REGULATION; INTERLEUKIN 1BETA; MONONUCLEAR CELL; OSTEOBLAST; OSTEOCLAST; TARTRATE RESISTANT ACID PHOSPHATASE;

EID: 0033784341     PISSN: 09209069     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1008198120670     Document Type: Article

References (34)

1. Osteoclastogenesis inhibitory factor suppresses osteoclast survival by interfering in the interaction of stromal cells with osteoclasts
2. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
3. Cellular biology of bone-resorbing cells
4. NF-κB: Ten years after
5. The NF-kappa B and I kappa B proteins: New discoveries and insights
6. Characterization of the intracellular domain of receptor activator of NF-κB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-κB and c-Jun N-terminal kinase
7. TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts
8. Macrophage colony-stimulating factor and interleukin-1 alpha maintain the survival of osteoclast-like cells
9. Activation of NF-κB is involved in the survival of osteoclasts promoted by interleukin-1
10. Interleukin 1 induces multinucleation and bone-resorbing activity of osteoclasts in the absence of osteoblasts/stromal cells
11. Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
12. Osteprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
13. MAP3K-related kinase involved in NF-κB induction by TNF, CD95 and IL-1
14. IKK-1 and IKK-2: Cytokine-activated IκB kinases essential for NF-κB activation
15. RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis
16. Wortmannin, a specific inhibitor of phosphatidylinositol-3 kinase, blocks osteoclastic bone resorption
17. Identification and characterization of an IκB kinase
18. A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor
19. Advances in bone biology: The osteoclasts
20. In vitro osteoclast generation from different bone marrow fractions, including a highly enriched haematopoietic stem cell population
21. Structure, regulation and function of NF-κB
22. Osteoprotegerin: A novel secreted protein involved in the regulation of bone density
23. Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of nuclear factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2
24. Regulation of osteoclast function
25. Cells of bone: Osteoclast generation
26. Modulation of osteoclast differentiation: Update
27. Requirement of osteoblastic cells for the fusion of preosteoclasts
28. Osteoblastic cells are involved in osteoclast formation
29. Isolation and characterization of highly enriched, prefusion mouse osteoclastic cells
30. TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells
31. TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor
32. The TRAF family of signal transducers mediates NF-κB activation by the TRANCE receptor
33. IκB kinase-beta: NF-κB activation and complex formation with IκB kinase-alpha and NIK
34. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL