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Nature
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MAP kinase and Wnt pathways converge to down-regulate an HMG domain represser in C. elegans
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in press
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Wesley C: Notch and Wingless regulate expression of cuticle patterning genes. Mol Cell Biol 1999, in press. Notch is a single transmembrane receptor with a well characterized role in the process of lateral inhibition, where it uses the transmembrane protein Delta as ligand. The author reports a series of experiments which show that the Drosophila Wnt, Wingless, can bind the Notch receptor in tissue culture and in developing embryos. Wingless appears as a Notch-binding protein in a biopanning assay for Notch ligands, can be immunoprecipitated with Notch in vivo and in tissue culture, and can adhere to the surface of Notch-expressing cells in a specific manner. The interaction between Notch and Wingless is mediated by extracellular regions of Notch that are different from those involved in interactions with Delta. Experiments in cultured cells indicate that these interactions can modulate novel activities of Notch which might contribute to Wingless signalling in vivo.
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