Heightened resistance of the neonatal brain to ischemia-reperfusion involves a lack of mitochondrial damage in the nerve terminal

Brain Research

Volumn 821, Issue 1, 1999, Pages 124-133

  Keelan, Julie ^a   Bates, Timothy E ^a   Clark, John B ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Brain; Development; Ischemia; Mitochondria; Reactive oxygen species

Indexed keywords

ADENOSINE TRIPHOSPHATE; MITOCHONDRIAL ENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); UBIQUINOL CYTOCHROME C REDUCTASE;

ADOLESCENT; AGE; ANIMAL TISSUE; ARTICLE; BRAIN HYPOXIA; BRAIN ISCHEMIA; BRAIN MITOCHONDRION; BRAIN SYNAPTOSOME; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; IN VITRO STUDY; MALE; NERVE ENDING; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; RESPIRATORY CHAIN;

EID: 0033528423     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)01084-7     Document Type: Article

References (36)

1. K.L. Allen, A. Almeida, T.E. Bates, J.B. Clark, Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischemia, J. Neurochem. 64 (1995) 2222-2229.
2. A. Almeida, K.L. Allen, T.E. Bates, J.B. Clark, Effect of reperfusion following cerebral-ischemia on the activity of the mitochondrial respiratory chain in the gerbil brain, J. Neurochem. 65 (1995) 1698-1703.
3. J.P. Bolanos, S. Peuchen, S.J.R. Heales, J.M. Land, J.B. Clark, Nitric oxide mediated inhibition of the mitochondrial respiratory chain in cultured astrocytes, J. Neurochem. 63 (1994) 910-916.
4. R.F.G. Booth, J.B. Clark, A rapid method for the preparation of relatively pure metabolically competent synaptosomes from rat brain, Biochem. J. 298 (1978) 249-258.
5. C. Bright, D. Ellis, Intracellular pH changes induced by hypoxia and anoxia in isolated sheep heart Purkinje-Fibers, Exp. Physiol. 7 (1992) 165-175.
6. J.B. Clark, W.J. Nicklas, The metabolism of rat brain mitochondria, J. Biol. Chem. 245 (1970) 4724-4731.
7. G.P. Davey, J.B. Clark, Threshold effects and control of oxidative phosphorylation in nonsynaptic rat brain mitochondria from hippocampal CA1 and paramedian neocortex brain regions, J. Neurochem. 66 (1996) 1617-1624.
8. G.P. Davey, J.B. Clark, Threshold effects in synaptosomal and nonsynaptic mitochondria from hippocampal CA1 and paramedian neocortex brain regions, J. Neurochem. 69 (1997) 2564-2570.
9. M. Erecinska, D. Nelson, M. Yudkoff, I.A. Silver, Energetics of the nerve terminal in relation to central nervous system function, Biochem. Soc. Trans. 22 (1994) 959-965.
10. R. Hawkins, Cerebral energy metabolism, Cerebral Energy Metabolism and Metabolic Encephalopathy, Plenum, New York, 1985, pp. 3-17.
11. L. Hillered, B.K. Seisj, K.E. Arfors, Mitochondrial response to transient forebrain ischemia and recirculation in the rat, J. Cereb. Blood Flow Metab. 4 (1984) 438-446.
12. J. Keelan, T.E. Bates, J.B. Clark, Intrasynaptosomal free calcium concentration during rat brain development, J. Neurochem. 66 (1996) 2460-2467.
13. J. Keelan, M.P. Brand, T.E. Bates, J.M. Land, J.B. Clark, S.J.R. Heales, Nitric oxide and antioxidant status in glucose and oxygen deprived neonatal and adult rat brain synaptosomes, Neurochem. Res. 21 (1996) 923-927.
14. J. Keelan, A Study of the Effects of Glucose and Oxygen Deficiency on the Function of Synaptosomes: a Model for Ischemia in the Immature and Adult Rat Brain, PhD Thesis, University of London, 1997.
15. 1 particle, and reconstitution of succinate cytochrome c reductase, Methods Enzymol. 10 (1967) 217-235.
16. O.H. Lowry, N.J. Rosenbrough, A.L. Farr, R.J. Randall, Protein measurement with the Folin phenol reagent, J. Biol. Chem. 193 (1951) 265-275.
17. W.J. Mergner, M.W. Smith, B.F. Trump, Studies on the pathogenesis of ischemic cell injury: XI. P/O ratio and acceptor control, Virchows Arch. [B] 26 (1977) 17-26.
18. I. Nakahara, H. Kikuchi, W. Taki, S. Nishi, H. Kido, Y. Yonekawa, Y. Goto, N. Ogata, Degradation of mitochondrial phospholipids during experimental cerebral ischemia in rats, J. Neurochem. 57 (1991) 839-844.
19. J.P. Nowicki, E.T. Mackenzie, A.R. Young, Brain ischemia, calcium and calcium antagonists, Pathologie Biologie 30 (1982) 282-288.
20. L. Pang, C. Eyzaguirre, Hypoxia affects differently the intracellular-pH of clustered and isolated Glomus Cells of the rat Carotid-Body, Brain Research 623 (1993) 349-355.
21. J.W. Phillis, A 'radical' view of cerebral ischemic injury, Prog. Neurobiol. 42 (1994) 441-448.
22. R. Radi, M. Rodriguez, L. Castro, R. Telleri, Inhibition of mitochondrial electron-transport by peroxynitrite, Arch. Biochem. Biophys. 308 (1994) 89-95.
23. C.I. Ragan, M.T. Wilson, V.M. Darley Usmar, P.N. Lowe, Subfractionation of mitochondria, and isolation of the proteins of oxidative phosphorylation, Mitochondria, A Practical Approach, IRL Press, London, 1987, pp. 79-112.
24. S. Rehncrona, L. Mela, B.K. Siesjö, Recovery of brain mitochondrial function in the rat after complete and incomplete cerebral ischemia, Stroke 10 (1979) 437-446.
25. I. Roman, A. Clark, P.D. Swanson, The interaction of calcium-transport and ADP phosphorylation in brain mitochondria, Membrane Biochemistry 4 (1981) 1-9.
26. H. Schweiger, E. Arnold, W. Koch, R. Nitshe, K. Brand, Ischemia-induced alterations of mitochondrial structure and function in brain, liver and heart muscle of young and senescent rats, Biochem. Med. Metab. Biol. 40 (1991) 162-185.
27. B.K. Seisjo, Cerebral circulation and metabolism, J. Neurosurg. 60 (1981) 883-908.
28. N.R. Sims, W.A. Pulsinelli, Altered mitochondrial respiration in selectively vulnerable brain subregions following transient forebrain ischemia in the rat, J. Neurochem. 49 (1987) 1367-1374.
29. J.W. Soper, P.L. Pedersen, Isolation of an oligomycin-sensitive ATPase complex from rat liver mitochondria, Methods Enzymol. 55 (1979) 328-333.
30. B. Soussi, J.P. Idstrom, T. Schersten, A.C. Bylundfellenius, Cytochrome C oxidase and cardiolipin alterations in response to skeletal muscle ischemia and reperfusion. Acta Physiologica Scandinavica, 138, pp. 107-114.
31. R.W. Taylor, M.A. Birch-Marchin, K. Bartlett, M. Turnbull, Succinate-cytochrome c reductase: assessment of its value in the investigation of defects of the respiratory chain. Biochimica et Biophysica Acta, 1994.
32. A. Thore, Technical aspects of the bioluminescent firefly luciferase assay of ATP, Science Tools 26 (1979) 30-34.
33. K. Veitch, A. Hombroeck, D. Caucheteux, H. Pouleur, L. Hue, Global-ischemia induces a biphasic response of the mitochondrial respiratory chain - anoxic pre-perfusion protects against ischemic damage, Biochem. J. 281 (1992) 709-715.
34. J.J. Volpe, Brain injury in the premature infant: is it preventable?, Pediatr. Res. 27 (1990) s28-s233.
35. D.C. Wharton, A. Tzagoloff, Cytochrome oxidase from beef heart mitochondria, Methods Enzymol. 10 (1967) 245-250.
36. E. Zaidan, N.R. Sims, Selective reductions in the activity of the pyruvate dehydrogenase complex in mitochondria isolated from brain subregions following forebrain ischemia in rats, J. Cereb. Blood Flow Metab. 13 (1993) 98-104.