Mechanism of action of volatile anesthetics: Effects of halothane on glutamate receptors in vitro

Toxicology Letters

Volumn 100-101, Issue , 1998, Pages 65-69

  Perouansky, Misha ^a   Kirson, Eilon D ^b   Yaari, Yoel ^b  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b HEBREW UNIVERSITY   (Israel)

Author keywords

Anesthetics, volatile; Animals, mouse; Brain, hippocampus; Central nervous system, excitatory postsynaptic currents; Halothane; Measurement technique, hippocampal slice, patch clamp; Neuron, interneuron, pyramidal cell; Receptors, glutamate, N methyl d aspartate, non N methyl d aspartate

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; GLUTAMATE RECEPTOR; HALOTHANE; INHALATION ANESTHETIC AGENT; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RECEPTOR SUBTYPE;

ANIMAL TISSUE; BRAIN SLICE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG MECHANISM; EVOKED RESPONSE; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; IN VITRO STUDY; INTERNEURON; MOUSE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL;

ACTION POTENTIALS; ANESTHETICS, INHALATION; ANIMALS; EXCITATORY AMINO ACID AGONISTS; EXCITATORY POSTSYNAPTIC POTENTIALS; HALOTHANE; HIPPOCAMPUS; INTERNEURONS; IONTOPHORESIS; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; PYRAMIDAL CELLS; RATS; RECEPTORS, GLUTAMATE;

ANIMALIA;

EID: 0032446706     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(98)00166-0     Document Type: Conference Paper

References (4)

1. Lacaille, J.-C., Muller, A.L., Kunkel, D.D., Schwartzkroin, P.A., 1987. Local circuit interactions between oriens/alveus intemeurons and CA1 pyramidal cells in hippocampal slices: electrophysiology and morphology. J. Neurosci. 7, 1979-1993.
2. Perouansky, M., Baranov, D., Salman, M., Yaari, Y., 1995. Effects of halothane on glutamate receptor-mediated excitatory postsynaptic currents. Anesthesiology 83, 109-119.
3. Perouansky, M., Kirson, E.D., Yaari, Y., 1996. Halothane blocks synaptic excitation of inhibitory intemeurons. Anesthesiology 85, 1431-1438.
4. Pocock, G., Richards, C.D., 1993. Excitatory and inhibitory synaptic mechanisms in anaesthesia. Br. J. Anaesth. 71, 13-147.