Coming of age: 'Dysgenetics' - A theory connecting induction of persistent delayed genomic instability with disturbed cellular ageing

International Journal of Radiation Biology

Volumn 76, Issue 11, 2000, Pages 1533-1543

  Simons, J W I M ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL AGING; DNA DAMAGE; GENOME; HUMAN; IONIZING RADIATION; NONHUMAN; PRIORITY JOURNAL; RADIATION CARCINOGENESIS; RADIATION INJURY; THEORY;

EID: 0033766680     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/09553000050176298     Document Type: Article

References (91)

1. Changes in jun N-terminal kinase activation by stress during ageing of cultured normal human fibroblasts
2. Lethal mutations attributable to misrepair of Q-lesions
3. Mutation in eukaryotes
4. Oncogenic transformation of C3H10T1/2 cells by X-rays, fast fission neutrons and cyclotron-produced neutrons
5. Slow clones, reduced clonogenicity, and intraclonal recovery in X-irradiated L5178Y-S cell cultures
6. A possible factor in genetic instability of cancer cells: Stress-induced secreted proteins lead to decrease in replication fidelity
7. Concomitant induction of signal transduction pathways and genetic instability by the tumour promoter 12-O-tetradecanoylphorbol-13-acetate
8. Stress response induced by DNA damage leads to specific, delayed and untargeted mutations
9. Immortalization of Syrian hamster embryo cells: Pobabilistic event or deterministic process
10. Clonogenicity of the progeny of surviving cells after irradiation
11. The proliferative capacity of mouse fibrosarcoma cells that survived X-irradiation
12. Effect of low dose rate ionizing radiation on the division potential of cells in vitro. VIII. Cytogenetic analysis of human fibroblasts
13. Clonal heterogeneity in the progeny of Hela cells which survive X-irradiation
14. Evidence for a role for genomic instability in radiation-induced mutagenesis
15. Delayed reproductive death in X-irradiated Chinese hamster ovary cells
16. Evidence that DNA double-strand breaks initiate the phenotype of delayed reproductive death in Chinese hamster ovary cells
17. Persistently elevated frequency of spontaneous mutations in progeny of CHO clones surviving X-irradiation: Association with delayed reproductive death phenotype
18. Delayed reproductive death as a dominant phenotype in cell clones surviving X-irradiation
19. Contribution of lethal mutations to excision assays for tumour cell survival
20. Radiation-induced genomic instability and persisting oxidative stress in primary bone marrow cultures
21. Induction of multiple PCR-SSCPE mobility shifts in p53 exons in cultures of normal human urothelium exposed to low-dose gamma-radiation
22. Ultraviolet reactivation of Herpes Simplex Virus is mutagenic and inducible in mammalian cells
23. Frequency of spontaneous and induced micronuclei in the peripheral blood of ageing mice
24. Recombination involving interstitial telomere repeat-like sequences promotes chromosomal instability in Chinese hamster cells
25. Alpha-particle-induced sister chromatid exchange in normal human lung fibroblasts: Evidence for an extranuclear target
26. Mouse minisatellite mutations induced by ionizing radiation
27. Alpha-particle after effects
28. Probabilistic view of the transformation of cultured C3H/10T1/2 mouse embryo fibroblasts by 3-methylcholantrene
29. Expression of lethal mutations in the progeny of irradiated mammalian cells
30. Clonal analysis of delayed karyotype abnormalities and gene mutations in radiation-induced genetic instability
31. Delayed appearance of radiation-induced mutations at the Hprt locus in murine hemopoietic cells
32. Delayed chromosomal instability in human T-lymphocyte clones exposed to ionizing radiation
33. Chromosomal instability in human lymphocytes after low dose rate gamma-irradiation and delayed mitogen stimulation
34. Increased micronucleus frequency in the progeny of irradiated Chinese hamster cells
35. Persistent increase in the rates of apoptosis and dicentric chromosomes in surviving V79 cells after irradiation
36. α-Particle-induced chromosomal instability in human bone marrow cells
37. Radiation-induced genomic instability: Delayed cytogenetic aberrations and apoptosis in primary human bone marrow cells
38. Transmission of chromosomal instability after plutonium α-particle irradiation
39. Radiation-induced chromosomal instability in human fibroblasts: Temporal effects and the influence of radiation quality
40. No association between p53 status and α-particle-induced chromosomal instability in human lymphoblastoid cells
41. Relationship between X-ray exposure and malignant transformation in C3H/10T1/2 cells
42. 238Pu α-particles
43. Ascertainment of the effects of differential growth rates of mutants on observed mutant frequencies in X-irradiated cells. An indication for the occurrence of X-ray induced untargeted mutagenesis
44. Radiation-induced genomic instability
45. Radiation induced chromosomal instability in human T-lymphocytes
46. Radiation induced chromosomal instability in human T-lymphocytes
47. Heat shock response, heat shock transcription factor and cell ageing
48. Extracellular factor(s) following exposure to alpha particles can cause sister chromatid exchanges in normal human cells
49. Apoptosis, reproductive failure, and oxidative stress in Chinese hamster ovary cells with compromised genomic integrity
50. Differential induction of chromosomal instability by DNA strand-breaking agents
51. Chromosomal instability and its relationship to other end points of genomic instability
52. Radiation-induced genomic instability
53. Delayed appearance of lethal and specific gene mutations in irradiated mammalian cells
54. Radiation-induced genomic instability: Delayed mutagenic and cytogenetic effects of X rays and alpha particles
55. Chromosomal instability in the descendants of unirradiated surviving cells after α-particle irradiation
56. Persistent expression of morphological abnormalities in the distant progeny of irradiated cells
57. Genomic instability in Chinese hamster cells after exposure to X-rays or alpha particles of different mean linear energy transfer
58. Delayed chromosomal instability induced by DNA damage
59. Specific chromosome instability induced by heavy ions: A step towards transformation of human fibroblasts?
60. Plating efficiency as a function of time post irradiation. Evidence for the delayed expression of lethal mutations
61. Micronucleus formation in preimplantated mouse embryos cultured in vitro after irradiation with X-rays and neutrons
62. Genomic instability induced by ionizing radiation
63. Lethal mutations and genomic instability
64. Mechanisms and implications of genomic instability and other delayed effects of ionizing radiation exposure
65. Expression of delayed toxicity and lethal mutation in the progeny of human cells surviving exposure to radiation and other environmental mutagens
66. Induction of sister chromatid exchanges by extremely low doses of alpha-particles
67. Increased chromosome aberration levels in cells from mouse fetuses after zygote X-irradiation
68. Radiation induced chromosomal instability in BALB/c and C57BL/6 mice: The difference is as clear as black and white
69. Induction of chromosomal instability in human mammary cells by neutrons and gamma rays
70. The evolution of chromosomal instability in Chinese hamster cells: A changing picture?
71. Studies of bystander effects in human fibroblasts using a charged particle microbeam
72. Radiation-enhanced differentiation of erythroid progenitor cells and its relation to reproductive cell death
73. Latent expression of p53 mutations and radiation-induced mammary cancer
74. Exploring the systems of life
75. Delayed expression of lethal mutations and genomic instability in the progeny of human epithelial cells that survived in a bystander-killing environment
76. High yields of lethal mutations in somatic mammalian cells that survive ionizing radiation
77. Genetic, epigenetic, dysgenetic and non-genetic mechanisms in tumorigenesis
78. Genetic, epigenetic, dysgenetic and non-genetic mechanisms in tumorigenesis. II. Further delineation of the rate limiting step
79. A theory on cellular ageing and cell immortalization
80. X-ray-induced heritable damage (small-colony-formation) in cultured mammalian cells
81. EMS and UV-light-induced colony sectoring and delayed mutation in Chinese hamster cells
82. In situ detection of chromosome bridge formation and delayed reproductive death in normal human embryonic cells surviving X-irradiation
83. X-irradiation-induced transformation in a C3H mouse embryo-derived cell line
84. Manifestations and mechanisms of radiation-induced genomic instability in V-79 Chinese hamster cells
85. Radiation-induced instability and its relation to radiation carcinogenesis
86. Mutation frequency declines during spermatogenesis in young mice but increases in old mice
87. Genetic factors influencing α-particle-induced chromosomal instability
88. Long-term in vivo transmission of α-particle-induced chromosomal instability in murine haemopoietic cells
89. Radiation-induced genomic instability in haemopoietic cells: Implications for radiation pathology
90. Radiation-induced genomic instability in haemopoietic cells
91. Inherited and inducible chromosomal instability: A fragile bridge between genome integrity mechanisms and tumourigenesis