Radiation-induced chromosomal instability in human fibroblasts: Temporal effects and the influence of radiation quality

International Journal of Radiation Biology

Volumn 73, Issue 2, 1998, Pages 143-148

  Kadhim, M A ^a   Marsden, S J ^a   Wright, E G ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA RADIATION; ARTICLE; CHROMOSOME DAMAGE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; FETUS; FIBROBLAST; HUMAN; HUMAN CELL; NEUTRON RADIATION; PRIORITY JOURNAL; RADIATION DOSE; RADIATION INJURY; X IRRADIATION;

ALPHA PARTICLES; CELLS, CULTURED; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN; FIBROBLASTS; HUMANS; NEUTRONS; X-RAYS;

EID: 0031892127     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/095530098142518     Document Type: Article

References (27)

1. BORN, R. and TROTT, K. R., 1988, Clonogenicity of the progeny of surviving cells after irradiation. International Journal of Radiation Biology, 53, 319-330.
2. BROWN, D. C. and TROTT, K. R., 1994, Heterogeneity in the progeny of HeLa cells which survive X-irradiation. International Journal of Radiation Biology, 66, 151-155.
3. CHANG, W. P. and LITTLE, J. B., 1992, Persistently elevated frequency of spontaneous mutations in progeny of CHO clones surviving X irradiation: association with delayed reproductive death phenotype. Mutation Research, 270, 191-199.
4. CLUTTON, S. M., TOWNSEND, K. M. S., WALKER, C., ANSELL, J. D. and WRIGHT, E. G., 1996, Radiation-induced genomic instability and persisting oxidative stress in bone marrow cultures. Carcinogenesis, 17, 1633-1639.
5. Cox, R. and MASSON, W. K., 1975, X-ray survival curves of cultured human diploid fibroblasts. In Cell Survival after Low Doses of Radiation: Theoretical and Clinical Implications. Proceedings of the 6th L. H. Gray Conference, edited by T. Alper (London: Institute of Physics/Chichester: John Wiley), pp. 217-222.
6. Cox, R., THACKER, J., GOODHEAD, D. T. and MUNSON, R. J., 1977, Mutation and inactivation of mammalian cells by various ionising radiations. Nature, 267, 425-427.
7. DURANTE, M., GROSSI, G. F. and YANG, T. C., 1996, Radiation-induced chromosomal instability in human mammary epithelial cells. Advances in Space Research, 18, 99-108.
8. EVANS, E. P., 1987, Karyotyping and sexing of gametes, embryos and fetuses and in situ hybridization to chromosomes. In Mammalian Development: a Practical Approach, edited by M Monk, (Oxford: IRL Press), pp. 93-114.
9. GOODHEAD, D. T., BANCE, D. A., STRETCH, A. and WILKINSON, R. E., 1991, A versatile plutonium-238 irradiator for radiobiological studies with α-particles. International Journal of Radiation Biology, 59, 195-210.
10. GOODHEAD, D. T., MUNSON, R. J., THACKER, J. and Cox, R., 1980, Mutation and inactivation of cultured mammalian cells exposed to beams of accelerated heavy ions. IV. Biophysical interpretation. International Journal of Radiation Biology, 37, 135-167.
11. GORGOJO, L. and LITTLE, J. B., 1989, Expression of lethal mutations in the progeny of irradiated mammalian cells. International Journal of Radiation Biology, 55, 619-630.
12. GRIFFIN, C. S., MARSDEN, S. J., STEVENS, D. L., SIMPSON, P. and SAVAGE J. R. K., 1995, Frequencies of complex exchange aberrations induced by Pu-238 α-particles and detected by fluorescence in situ hybridization using single chromosome-specific probes. International Journal of Radiation Biology, 67, 431-439.
13. HARPER, K., LORIMORE, S. A. and WRIGHT, E. G., 1997, Delayed appearance of radiation-induced mutations at the Hprt locus in murine haemopoietic cells. Experimental Hematology, 25, 263-269.
14. HOLMBERG, K., FALT, S., JOHANSSON, A. and LAMBERT, B., 1993, Chromosome aberrations and genomic instability in X-irradiated human T-lymphocyte cultures. Mutation Research, 286, 321-330.
15. HOLMBERG, K., MEIJER, A. E., AUER, G. and LAMBERT, B., 1995, Delayed chromosomal instability in human T-lymphocyte clones exposed to ionizing radiation. International Journal of Radiation Biology, 68, 245-255.
16. KADHIM, M. A., LORIMORE, S. A., HEPBURN, M. D., GOODHRAD, D. T., BUCKLE, V. J. and WRIGHT, E. G., 1994, Alpha-particle-induced chromosomal instability in human bone marrow cells. Lancet, 344, 987-988.
17. KADHIM, M. A., LORIMORE, S. A., TOWNSEND, K. M. S, GOODHEAD, D. T., BUCKLE, V. J. and WRIGHT, E. G., 1995, Radiation-induced genomic instability: delayed cytogenetic aberrations and apoptosis in primary human bone marrow cells. International Journal of Radiation Biology, 67, 287-293.
18. KADHIM, M. A., MACDONALD, D. A., GOODHEAB, D. T., LORIMORE, S. A., MARSDEN, S. J. and WRIGHT, E. G., 1992, Transmission of chromosomal instability after plutonium α-particle irradiation. Nature, 355, 738-740.
19. LITTLE, J. B., GORGOJO, L. and VETROS, H., 1990, Delayed appearance of lethal and specific gene mutations in irradiated mammalian cells. International Journal of Radiation Oncology, Biology, Physics, 19, 1425-1429.
20. MARDER, B. A. and MORGAN, W. F., 1993, Delayed chromosomal instability induced by DNA damage. Molecular and Cellular Biology, 13, 6667-6677.
21. MARTINS, M. B., SABATIER, L., RICOUL, M., PINTON, A. and DUTRILLAUX, B., 1993, Specific chromosome instability induced by heavy ions: a step towards transformation of human fibroblasts. Mutation Research, 285, 229-237.
22. PAMPFER, S. and STREFFER, C., 1989, Increased chromosome aberration levels in cells from mouse fetuses after zygote X-irradiation. International Journal of Radiation Biology, 55, 85-92.
23. PONNAIYA, B., GORNFORTH, M. N. and ULLRICH, R. L., 1997a, Radiation-induced chromosomal instability in BALB/c and C57BL/6 mice. The difference is as clear as black and white. Radiation Research, 147, 121-125.
24. PONNAIYA, B., CORNFORTH, M. N. and ULLRICH, R. L., 1997b, Induction of chromosomal instability in human mammary cells by neutrons and gamma rays. Radiation Research, 147, 288-294.
25. SAVAGE, J. R. K., 1976, Classification and relationship of induced chromosomal structural changes. Journal of Medical Genetics, 13, 103-122.
26. SEYMOUR, C. B., MOTHERSILL, C. and ALPER, T., 1986, High yields of lethal mutations in somatic mammalian cells that survive ionizing radiation. International of Radiation Biology, 50, 167-179.
27. WATSON, G. E., LORIMORE, S. A., CLUTTON, S. M., KADHIM, M. A. and WRIGHT, E. G., 1997, Genetic factors influencing alpha-particle-induced chromosomal instability. International Journal of Radiation Biology, 71, 497-503.