New perspectives on the theory of permeability and resistance in the study of drug transport and absorption

Journal of Pharmacokinetics and Biopharmaceutics

Volumn 24, Issue 4, 1996, Pages 433-442

  Chiou, Win L ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Absorption; Absorptive clearance; Drug transport; Fick's law of diffusion; Intestinal absorption; Permeability; Transport resistance

Indexed keywords

ARTICLE; BLOOD FLOW; DRUG ABSORPTION; DRUG DIFFUSION; DRUG TRANSPORT; INTESTINE; PRIORITY JOURNAL; SKIN; STEADY STATE; THEORETICAL STUDY;

CELL MEMBRANE PERMEABILITY; HUMANS; INTESTINAL ABSORPTION; MODELS, BIOLOGICAL; PERMEABILITY; PHARMACOKINETICS;

EID: 0030514291     PISSN: 0090466X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02353521     Document Type: Article

References (26)

1. D. S. Riggs. The Mathematical Approach to Physiological Problems, MIT Press, Cambridge, MA, 1963, pp 181-185.
2. M. D. Stein. Transport and Diffusion Across Cell Membranes, Academic Press, New York, 1986.
3. H. D. Patton, A. F. Fuchs, B. Hille, A. M. Scher, and R. Steiner. Textbook of Physiology Excitable Cells and Neurophysiology, Vol. 1, 21st ed., W. B. Saunders, Philadelphia, pp. 16-19.
4. W. D. Stein. Channels, Carriers, and Pumps: An Introduction to Membrane Transport, Academic Press, New York, 1990.
5. A. Martin, J. Swarbrick, and A. Cammarata. Physical Pharmacy, 4th ed., Lea and Febiger, Philadelphia, 1993.
6. N. F. H. Ho, H. P. Merkle, and W. I. Higuchi. Quantitative, mechanistic and physiologically realistic approach to the biopharmaceutical design of oral drug delivery system. Drug. Dev. Ind. Pharm. 9:1111-1184 (1983).
7. H. Yuasa, K. Matsuda, and J. Watanabe. Influence of anesthetic regimens on the intestinal 5-fluorouracil in rats. Biol. Pharm. Bull. 18:747-752 (1995).
8. M. D. Levitt, J. M. Kneip, and D. G. Levitt. Use of laminar flow and unstirred layer models to predict intestinal absorption in the rat. J. Clin. Invest. 81:1365-1369 (1988).
9. H. Lennernäs, U. Fagerholm, Y. Raab, B. Gerdin and R. Hällgren Regional rectal perfusion: A new in vivo approach to study rectal drug absorption in man. Pharm. Res. 12:426-432 (1995).
10. P. Artursson and J. Karlsson. Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco 2) cells. Biochem. Biopys. Res. Commun. 175:880-885 (1991).
11. G. Amidon, H. Lennernäs, V. P. Shah, and J. R. Crison. A theoretical basis for a biopharmaceutical drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm. Res. 12:413-420 (1995).
12. W. L. Chiou. Determination of drug permeability in a flat or distended stirred intestine. Int. J. Clin. Pharmacol. Ther. 32:474-482 (1994).
13. W. L. Chiou. Effect of "unstirred" water layer in the intestine on the rat and extent of absorption after oral administration. Biopharm. Drug. Disp. 15:709-717 (1994).
14. W. L. Chiou. The validation of the intestinal permeability approach to predict oral fraction dose absorbed in humans and rats. Biopharm. Drug. Disp. 16:71-75 (1995).
15. H. Lennernäs, J. R. Crison, and G. L. Amidon. Permeability and clearance views of drug absorption: A commentary. J. Pharmacokin. Biopharm. 23:333-337 (1995).
16. W. L. Chiou. We may not measure the correct intestinal wall permeability coefficient of drugs: Alternative absorptive clearance concept. J. Pharmacokin. Biopharm. 23:323-331 (1995).
17. W. L. Chiou. The author relies to Lennernäs et al. J. Pharmacokin. Biopharm. 23:329-343 (1995).
18. B. J. Zwolinski, H. Eyring, and C. E, Reese. Diffusion and membrane permeability. J. Phys. Colloid Chem. 53:1426-1453 (1949).
19. Y. S. Choo, Y. M. Choi, and W. L. Chiou. Marked accumulation and long transit time of chloroquine in the intestinal wall of rats during absorption. Pharm. Res. 8:S253 (1991).
20. Y. S. Choo, Y. M. Choi, and W. L. Chiou. First-pass accumulation of drugs in gut wall after absorption: Mechanism and implications in absorption studies. Pharm. Res. 9:S3 (1992).
21. Y. M. Choi, S. M. Chung, and W. L. Chiou. First-pass accumulation of salicylic acid in gut tissue after absorption in anesthetized rats. Pharm. Res. 12:1323-1327 (1995).
22. G. L. Amidon, P. J. Sinko, and D. Fleisher. Estimating human fraction does absorbed: A correlation using rat intestinal membrane permeability for passive and carrier-mediated compounds. Pharm. Res. 5:651-654 (1988).
23. W. L. Hayton. Rate-limiting barriers to intestinal drug absorption: A review. J. Pharmacokin. Biopharm. 8:321-334 (1980).
24. D. Winne, H. Gorig, and U, Muller. Closed rat jejunal segment in situ: Role of preepithelial diffusion resistance (unstirred layer) in the absorption process and model analysis. Naunyn-Schmiedeberg's Arch. Pharmacol. 335:204-215 (1987).
25. W. L. Chiou, Mean hepatic transit time in the determination of mean absorption time. J. Pharm. Sci. 72:1365-1368 (1983).
26. K. Dackson, J. A. Stone, K. J. Palin, and W. N. Charman, Evaluation of the mass balance assumption with respect to the two-resistance model of intestinal absorption by using in situ single-pass intestinal perfusion of theophylline in rats. J. Pharm. Sci., 81:321-325 (1992).