Molecular determinants of inactivation in voltage-gated Ca2+ channels

Journal of Physiology

Volumn 528, Issue 2, 2000, Pages 237-249

  Hering, Steffen ^a   Berjukow, Stanislav ^a   Sokolov, Stanislav ^a   Marksteiner, Rainer ^a   Weiß, Regina G ^a   Kraus, Richard ^a   Timin, Evgeni N ^b  

^a A 6020   (Austria)

^b A V VISHNEVSKY INSTITUTE OF SURGERY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; CALCIUM ION; REGULATOR PROTEIN; CALCIUM CHANNEL CAV1; CALCIUM CHANNEL CAV2.1; CALCIUM CHANNEL CAV2.2; CALCIUM CHANNEL CAV2.3; CALCIUM CHANNEL CAV3; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; SYNTAXIN; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL;

ACTION POTENTIAL; ALPHA CHAIN; ANIMAL CELL; ATAXIA; BETA CHAIN; CALCIUM TRANSPORT; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CHANNEL GATING; CONFORMATIONAL TRANSITION; CONTROL SYSTEM; CONTROLLED STUDY; ELECTRIC POTENTIAL; KINETICS; MIGRAINE; MOLECULAR INTERACTION; MOUSE; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; REVIEW; SIGNAL TRANSDUCTION; SPLICEOSOME; STRUCTURE ANALYSIS; XENOPUS; ACTION POTENTIAL DURATION; AMINO ACID SUBSTITUTION; DISEASE ASSOCIATION; FAMILIAL HEMIPLEGIC MIGRAINE; GAIN OF FUNCTION MUTATION; HUMAN; HYDROPHOBICITY; MISSENSE MUTATION; NEGATIVE FEEDBACK; NERVE CELL MEMBRANE STEADY POTENTIAL; NEUROPATHOLOGY; POSITIVE FEEDBACK; POTASSIUM CURRENT; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION;

EID: 0033765089     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.2000.t01-1-00237.x     Document Type: Review

References (80)

1. 2+ channels by mibefradil
2. Structural regions of the cardiac Ca channel α subunits involved in Ca-dependent inactivation
3. Inactivation of the sodium channel. II. Gating current experiments
4. 2+ channel subunits reveal structural determinants of a guarded and modulated benzothiazepine receptor
5. Molecular mechanism of calcium channel block by isradipine: Role of a drug-induced inactivated channel conformation
6. Mutations in the EF-hand motif impair the inactivation of barium currents of the cardiac α1C channel
7. Elementary and global aspects of calcium signalling
8. Functional impact of syntaxin on gating of N-type and Q-type calcium channels
9. Splicing of α(1A) subunit gene generates phenotypic variants of P- and Q-type calcium channels
10. Calcium entry leads to inactivation of calcium channel in Paramecium
11. 2+ channels and snare proteins in neurotransmitter release
12. Voltage and calcium use the same molecular determinants to inactivate calcium channels
13. Identification of palmitoylation sites within the L-type calcium channel β2a subunit and effects on channel function
14. Syntaxin modulation of slow inactivation of N-type calcium channels
15. 2+ channels
16. 2+ channel expressed in Xenopus oocytes
17. Direct binding of G-protein βγ complex to voltage-dependent calcium channels
18. Mechanisms of modulation of voltage-dependent calcium channels by G proteins
19. The effect of α2-δ and other accessory subunits on expression and properties of the calcium channel α1G
20. Transfer of L-type calcium channel IVS6 segment increases phenylalkylamine sensitivity of α1A
21. + conduction and selectivity
22. 2+ interactions
23. Nomenclature of voltage-gated calcium channels
24. Absence epilepsy in tottering mutant mice is associated with calcium channel defects
25. Inactivation of presynaptic calcium current contributes to synaptic depression at a fast central synapse
26. 2+ currents and alters channel inactivation properties
27. Calcium-dependent inactivation of potential-dependent calcium inward current in an isolated guinea-pig smooth muscle cell
28. 2δ auxiliary subunit gene (CACNA2D2)
29. Transfer of 1,4-dihydropyridine sensitivity from L-type to class A (BI) calcium channels
30. Functional consequences of mutations in the human α1A calcium channel subunit linked to familial hemiplegic migraine
31. Structural elements in domain IV that influence biophysical and pharmacological properties of human α1A-containing high-voltage-activated calcium channels
32. Transfer of high sensitivity for benzothiazepines from L-type to class A (BI) calcium channels
33. Molecular mechanism of use-dependent calcium channel block by phenylalkylamines: Role of inactivation
34. Calcium channel block and inactivation: Common molecular determinants
35. Molecular determinants of inactivation and G protein modulation in the intracellular loop connecting domains I and II of the calcium channel α(1A) subunit
36. Molecular determinants of high affinity phenylalkylamine block of L-type calcium channels in transmembrane segment IIIS6 and the pore region of the α1 subunit
37. Molecular determinants of high affinity phenylalkylamine block of L-type calcium channels
38. Molecular determinants of drug binding and action on L-type calcium channels
39. Voltage-dependent calcium channels: From structure to function
40. Biophysical and molecular mechanisms of Shaker potassium channel inactivation
41. Calcium channelopathies in the central nervous system
42. 2+ channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the α(1A)-subunit
43. A family of γ-like calcium channel subunits
44. 2+ channel kinetics
45. 2+ channel kinetics
46. 2+/calmodulin binds to and modulates P/Q-type calcium channels
47. Inactivation of calcium channels in mammalian heart cells: Joint dependence on membrane potential and intracellular calcium
48. A region in IVS5 of the human cardiac L-type calcium channel is required for the use-dependent block by phenylalkylamines and benzothiazepines
49. 2+ channel gene CACNL1A4
50. Voltage-dependent inactivation in a cardiac-skeletal chimeric calcium channel
51. Preferential closed-state inactivation of neuronal calcium channels
52. Molecular characterization of two members of the T-type calcium channel family
53. 2+-dependent inactivation of L-type calcium channels
54. 2+ channels
55. 2+ channel mutation
56. Calcium channel β-subunit binds to a conserved motif in the I-II cytoplasmic linker of the α1-subunit
57. 2+ channel depends on calmodulin
58. 2+ channels with the presynaptic proteins syntaxin and SNAP-25
59. Distinctive biophysical and pharmacological properties of class A (BI) calcium channel α1 subunits
60. 1-subunit and β-subunit interaction affect sensitivity for the phenylalkylamine (-)gallopamil
61. 2+ channels by β-subunits
62. 2+ channel inactivation. Segment exchange analysis of the carboxyl-terminal cytoplasmic motif encoded by exons 40-42 of the human α1C subunit gene
63. 2+ dependence of inactivation
64. Multiple structural domains contribute to voltage-dependent inactivation of rat brain α(1E) calcium channels
65. Localization and functional properties of a rat brain α(1A) calcium channel reflect similarities to neuronal Q- and P-type channels
66. Fast inactivation of voltage-dependent calcium channels. A hinged-lid mechanism?
67. 2+ channels
68. Molecular localization of regions in the L-type calcium channel critical for dihydropyridine action
69. 2+-dependent inactivation of P-type calcium channels in nerve terminals
70. Single tottering mutations responsible for the neuropathic phenotype of the P-type calcium channel
71. 2+ channel α(1A) subunit
72. 2+ channel activation
73. + channel inactivation
74. Structure and functional expression of α1, α2, and β subunits of a novel human neuronal calcium channel subtype
75. Calcium channel types with distinct presynaptic localization couple differentially to transmitter release in single calyx-type synapses
76. Molecular determinants of voltage-dependent inactivation in calcium channels
77. 2+ channels by SNAP-25, syntaxin and synaptotagmin
78. Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the α(1A)-voltage-dependent calcium channel
79. Calmodulin supports both inactivation and facilitation of L-type calcium channels