Role of NFAT in the regulation of B-1 cells

Current Topics in Microbiology and Immunology

Volumn 252, Issue , 2000, Pages 131-140

  Berland, R ^a   Wortis, H H ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD5 ANTIGEN; TRANSCRIPTION FACTOR;

ANTIGEN EXPRESSION; B LYMPHOCYTE; CONFERENCE PAPER; ENHANCER REGION; GENE DISRUPTION; GENE SEQUENCE; HUMAN; IMMUNOGENETICS; LYMPHOCYTE SUBPOPULATION; NONHUMAN; PERITONEUM CELL; PRIORITY JOURNAL; SEQUENCE HOMOLOGY;

EID: 0033762904     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-57284-5_14     Document Type: Conference Paper

References (27)

1. Antigen-induced lymphomagenesis: Identification of a murine B cell lymphoma with known antigen specificity
2. Development of B-1 cells: Segregation of phosphatidyl choline-specific B cells to the B-1 population occurs after immunoglobulin gene expression
3. The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins
4. Activation of B-cells by sIgM cross-linking induces accumulation of CD5 mRNA
5. An NFAT-clependent enhancer is necessary for anti-IgM-mediated induction of murine CD5 expression in primary splenic B cells
6. Induction of NF-AT in normal B lymphocytes by anti-immunoglobulin or CD40 ligand in conjunction with IL-4
7. Treatment of murine CD5- B cells with anti-Ig, but not LPS, induces surface CDS: Two B-cell activation pathways
8. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice
9. Positive selection of natural autoreactive B cells
10. Different nuclear signals are activated by the B cell receptor during positive versus negative signaling
11. Hyperproliferation and dysregulation of IL-4 expression in NF-ATp- deficient mice
12. Signal transducer and activator of transcription-3 (STAT3) is constitutively activated in normal, self-renewing B-1 cells but only inducibly expressed in conventional B lymphocytes
13. B cell antigen receptor specificity and surface density together determine B-1 versus B-2 cell development
14. Molecular linkage of the mouse CD5 and CD6 genes
15. T-cell receptor stimulation elicits an early phase of activation and a later phase of deactivation of the transcription factor NFAT1
16. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes
17. A transgenic model of autoimmune hemolytic anemia
18. The transcription factor NFAT4 is involved in the generation and survival of T cells
19. Delayed lymphoid repopulation with defects in IL4-driven responses produced by inactivation of NF-ATc
20. Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development
21. Transcription factors of the NFAT family: Regulation and function
22. Induction of phorbol ester responsiveness in conventional B cells after activation via surface Ig
23. Nuclear NF-ATp is a hallmark of unstimulated B cells from B-CLL patients
24. Induction of CD5 on B and T cells is suppressed by cyclosporin A, FK- 520 and rapamycin
25. Cyclosporin-A sensitive induction of NF-AT in murine B cells
26. Expression levels of B cell surface immunoglobulin regulate efficiency of allelic exclusion and size of autoreactive B-1 cell compartment
27. B-cell activation by crosslinking of surface IgM or ligation of CD40 involves alternative signal pathways and results in different B-cell phenotypes