Identification of a membrane targeting and degradation signal in the p42 protein of influenza C virus

Journal of Virology

Volumn 74, Issue 22, 2000, Pages 10480-10488

  Pekosz, A ^a   Lamb, R A ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; LACTACYSTIN; MESSENGER RNA; PROTEIN CM 2; PROTEIN P31; PROTEIN P42; SIGNAL PEPTIDE; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS RNA;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; DOG; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; HYDROPHOBICITY; INFLUENZA; INFLUENZA VIRUS C; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN TARGETING; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; VIRUS GENOME; VIRUS PATHOGENESIS;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CELL MEMBRANE; CYSTEINE ENDOPEPTIDASES; DNA, COMPLEMENTARY; DOGS; ENDOPLASMIC RETICULUM; HUMANS; INFLUENZAVIRUS C; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; MUTAGENESIS, SITE-DIRECTED; PLASMIDS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BIOSYNTHESIS; PROTEIN PRECURSORS; PROTEIN SORTING SIGNALS; RNA, VIRAL; TRANSCRIPTION, GENETIC; TRANSFECTION; VIRAL MATRIX PROTEINS; VIRAL PROTEINS;

EID: 0033761734     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.22.10480-10488.2000     Document Type: Article

References (56)

1. Antigenic, sequence, and crystal variation in influenza B neuraminidase
2. Retroviral vectors preloaded with a viral receptor-ligand bridge protein are targeted to specific cell types
3. Ubiquitin and the control of protein fate in the secretory and endocytic pathways
4. Effect of M1 protein and low pH on nuclear transport of influenza virus ribonucleoproteins
5. Epidemiology of influenza C virus in man: Multiple evolutionary lineages and low rate of change
6. Evidence that the amantadine-induced, M2-mediated conversion of influenza A virus hemagglutinin to the low pH conformation occurs in an acidic trans Golgi compartment
7. Regulation of pH by the M2 protein of influenza A viruses
8. Mechanistic studies on the inactivation of the proteasome by lactacystin in cultured cells
9. Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin
10. A viral inhibitor of peptide transporters for antigen presentation
11. 7 RNA polymerase
12. Influence of amantadine resistance mutations on the pH regulatory function of the M2 protein of influenza A viruses
13. Maturation of influenza A virus hemagglutinin - Estimates of the pH encountered during transport and its regulation by the M2 protein
14. Unpacking the incoming influenza virus
15. Herpes simplex virus turns off the TAP to evade host immunity
16. Identification of a 374 amino acid protein encoded by RNA segment 6 of influenza C virus
17. Characterization of a second protein (CM2) encoded by RNA segment 6 of influenza C virus
18. Influenza C virus CM2 protein is produced from a 374-amino-acid protein (P42) by signal peptidase cleavage
19. Identification of a second protein encoded by influenza C virus RNA segment 6
20. Misfolded major histocompatibility complex class I heavy chains are translocated into the cytoplasm and degraded by the proteasome
21. Evolutionary analysis of the influenza A virus M gene with comparison of the M1 and M2 proteins
22. The translocon: A dynamic gateway at the ER membrane
23. ER quality control: The cytoplasmic connection
24. Transport route for synaptobrevin via a novel pathway of insertion into the endoplasmic reticulum membrane
25. Evidence for a ninth influenza viral polypeptide
26. 2 ion channel protein and its role in the influenza virus life cycle
27. Orthomyxoviridae: The viruses and their replication
28. 2 protein is an integral membrane protein expressed on the infected-cell surface
29. Discrimination between ubiquitin-dependent and ubiquitin-independent proteolytic pathways by the 26S proteasome subunit 5a
30. Nuclear transport of influenza virus ribonucleoproteins: The viral matrix protein (M1) promotes export and inhibits import
31. Transport of incoming influenza virus nucleocapsids into the nucleus
32. Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination
33. Efficient selection for high-expression transfectants by a novel eukaryotic vector
34. Rescue of vector-expressed fowl plague virus hemagglutinin in biologically active form by acidotropic agents and coexpressed M2 protein
35. The molecular biology of influenza viruses and paramyxoviruses
36. The CM2 protein of influenza C virus is an oligomeric integral membrane glycoprotein structurally analogous to influenza A virus M2 and influenza B virus NB proteins
37. Influenza C virus CM2 integral membrane glycoprotein is produced from a polypeptide precursor by cleavage of an internal signal sequence
38. 2 protein has ion channel activity
39. A new cationic liposome reagent mediating nearly quantitative transfection of animal cells
40. 2 protein affects transport through the Golgi apparatus
41. Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination
42. Cell-specific viral targeting mediated by a soluble retroviral receptor-ligand fusion protein
43. The cytosolic tail of class I MHC heavy chain is required for its dislocation by the human cytomegalovirus US2 and US11 gene products
44. Structural characteristics of the M2 protein of the influenza A viruses: Evidence that it forms a tetrameric channel
45. Evolutionary analysis of influenza C virus M genes
46. 2 protein ion channel activity stabilizes the native form of fowl plague virus hemagglutinin during intracellular transport
47. ATP- and antizyme-dependent endoproteolysis of ornithine decarboxylase to oligopeptides by the 26 S proteasome
48. A small amphipathic alpha helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5
49. A 12-residue-long polyleucine tail is sufficient to anchor synaptobrevin to the endoplasmic reticulum membrane
50. The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol
51. Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction
52. 2-terminal region
53. Evidence that the matrix protein of influenza C virus is coded for by a spliced mRNA
54. 2 in virions
55. Characterization of the membrane association of the influenza virus matrix protein in living cells
56. Isolation of matrix protein M1 from influenza viruses by acid-dependent extraction with nonionic detergent