Novel isoforms of the fragile X related protein FXR1P are expressed during myogenesis

Human Molecular Genetics

Volumn 7, Issue 13, 1998, Pages 2121-2128

  Khandjian, E W ^e   Bardoni, B ^a,d   Corbin, F ^e   Sittler, A ^a,c   Giroux, S ^e   Heitz, D ^e   Tremblay, S ^e   Pinset, C ^b   Montarras, D ^b   Rousseau, F ^e   Mandel, J L ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b INSTITUT PASTEUR   (France)

^c MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^d UNIVERSITY OF PAVIA   (Italy)

^e NONE

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; RNA BINDING PROTEIN;

ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOPLASM; EXON; FRAGILE X SYNDROME; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MOUSE; MUSCLE CONTRACTION; MUSCLE DEVELOPMENT; MYOBLAST; MYOTUBE; NONHUMAN; POLYSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION;

EID: 7844239780     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/7.13.2121     Document Type: Article

References (29)

1. Oostra, B.A. and Willems, P.J. (1995) A fragile gene. BioEssays, 17, 941-947.
2. Warren, S.T. and Ashley, C.T. (1995) Triplet repeat expansion mutations: the example of fragile X syndrome. Annu. Rev. Neurosci., 18, 77-99.
3. Coy, J.F., Sedlacek, Z., Bächner, D., Hameister, H., Joos, S., Lichter, P., Delius, H. and Poustka, A. (1995) Highly conserved 3′ UTR and expression pattern of FXR1 points to a divergent gene regulation of FXR1 and FMR1. Hum. Mol. Genet., 4, 2209-2218.
4. Siomi, M.C., Siomi, H., Sauer, W.H., Srinivasan, S., Nussbaum, R.L. and Dreyfuss, G. (1995) FXR1, an autosomal homolog of the fragile X mental retardation gene. EMBO J., 14, 2401-2408.
5. Zhang, Y., O'Connor, J.P., Siomi, M.C., Srinivasan, S., Dutra, A., Nussbaum, R.L. and Dreyfuss, G. (1995) The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2. EMBO J., 14, 5358-5366.
6. Siomi, M.C., Zhang, Y., Siomi, H. and Dreyfuss, G. (1996) Specific sequences in the fragile X syndrome protein FMR1 and the FXR2 proteins mediate their binding to 60S ribosomal subunits and the interactions among them. Mol. Cell. Biol., 16, 3825-3832.
7. Eberhart, D.E., Malter, H.E., Feng, Y. and Warren, S.T. (1996) The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals. Hum. Mol. Genet., 5, 1083-1091.
8. Fridell, R.A., Benson, R.E., Hua, J., Bogerd, H.P. and Cullen, B.R. (1996) A nuclear role for the fragile X mental retardation protein. EMBO J., 15, 5408-5414.
9. Sittler, A., Devys, D., Weber, C. and Mandel, J.-L. (1996) Alternative splicing of exon 14 determines nuclear or cytoplasmic localisation of fmr1 protein isoforms. Hum. Mol. Genet., 5, 95-102.
10. Bardoni, B., Sittler, A., Shen, Y. and Mandel, J.-L. (1997) Analysis of domains affecting intracellular localization of the FMRP protein. Neurobiol. Dis., 4, 329-336.
11. Tamanini, F., Willemsen, R., van Unen, L., Bontekoe, C., Galjaard, H., Oostra, B.A. and Hoogeveen, A.T. (1997) Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis. Hum. Mol. Genet., 6, 1315-1322.
12. Montarras, D., Pinset, C., Chelly, J., Kahn, A. and Gros, F. (1989) Expression of MyoD1 coincides with terminal differentiation in determined but inducible muscle cells. EMBO J., 8, 2203-2207.
13. + mRNA in actively translating polyribosomes. Hum. Mol. Genet., 6, 1465-1472.
14. Feng, Y., Absher, D., Eberhart, D.E., Brown, V., Malter, H.E. and Warren, S.T. (1997) FMRP associates with polyribosomes as an mRNP and the 1304N mutation of severe fragile X syndrome abolishes this association. Mol. Cell, 1, 109-118.
15. Khandjian, E.W., Fortin, A., Thibodeau, A., Tremblay, S., Côté, F., Devys, D., Mandel, J.-L. and Rousseau, F. (1995) A heterogeneous set of FMR1 proteins is widely distributed in mouse tissues and is modulated in cell culture. Hum. Mol. Genet., 4, 783-789.
16. The Dutch-Belgian Fragile X Consortium (1994) FMR1 knockout mice: a model to study fragile X mental retardation. Cell, 78, 23-33.
17. Verheij, C., de Graaff, E., Bakker, C.E., Willemsen, R., Willems, P.J., Meijer, N., Galjaard, H., Reuser, A.J.J., Oostra, B.A. and Hoogeveen, A.T. (1995) Characterization of FMRI proteins isolated from different tissues. Hum. Mol. Genet., 4, 895-901.
18. Mandel, J.-L. and Pearson, M.L. (1974) Insulin stimulates myogenesis in a rat myoblast line. Nature (Lond.), 251, 618-620.
19. Khandjian, E.W., Corbin, F., Woerly, S. and Rousseau, F. (1996) The fragile X mental retardation protein is associated with ribosomes. Nature Genet., 12, 91-93.
20. Feng, Y., Gutekunst, C.-A., Eberhart, D.E., Yi, H., Warren, S.T. and Hersch, S.M. (1997) Fragile X mental retardation protein: nucleocytoplasmic shuttling and association with somatodendritic ribosomes. J. Neurosci., 17, 1539-1547.
21. Weiler, I.J., Irwin, S.A., Klintsova, A.Y. Spencer, C.M., Brazelton, A.D., Miyashiro, K., Comery, T.A., Patel, B., Eberwine, J. and Greenough, W.T. (1997) Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation. Proc. Natl Acad. Sci. USA, 94, 5395-5400.
22. Ziemiecki, A., Müller, R.G., Xiao-Chang, F., Hynes, N.E. and Kozma, S. (1990) Oncogenic activation of the human trk proto-oncogene by recombination with the ribosomal large subunit protein L7a. EMBO J., 9, 191-196.
23. Freshney, I.R. (1987) Culture of Animal Cells: A Manual of Basic Technique. Alan R. Liss, New York.
24. Devys, D., Lutz, Y., Rouyer, N., Bellocq, J.-P. and Mandel, J.-L. (1993) The FMR-1 protein is cytoplasmic, most abundant in neurons and appears normal in carriers of a fragile X premutation. Nature Genet., 4, 335-340.
25. Lentz, T.L. (1971) Cell Fine Structure: An Atlas of Drawings of Whole-Cell Structure, W. B. Saunders, Philadelphia, PA.
26. Fawcett, D.W. (1994) A Textbook of Histology. Chapman & Hall, New York.
27. Drouin, R., Angers, M., Dallaire, N., Rose, T.M., Khandjian, E.W. and Rousseau, F. (1997) Structural and functional characterization of the human FMR1 promoter reveals similarities with the hnRNP-A2 promoter region. Hum. Mol. Genet., 6, 2051-2060.
28. Yaffé, D. and Saxel, O. (1977) Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle. Nature (Lond.), 270, 725-727.
29. Kastner, P., Perez, A., Lutz, Y., Rochette-Egly, C., Gaub, M.P., Durand, B., Lanotte, M., Berger, R. and Chambon, P. (1992) Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins. EMBO J., 11, 629-642.