Safety and efficacy of in vivo gene transfer into the porcine heart with replication-deficient, recombinant adenovirus vectors

Gene Therapy

Volumn 3, Issue 2, 1996, Pages 145-153

  Muhlhauser J ^a,b   Jones, M ^a   Yamada, I ^a   Cirielli, C ^a   Lemarchand, P ^a   Gloe, T R ^a   Bewig, B ^a,c   Signoretti, S ^b   Crystal, R G ^a,c   Capogrossi, M C ^a,d  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

^c WEILL CORNELL MEDICAL CENTER   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Adenovirus; Gene therapy; Minipig; Myocardium

Indexed keywords

ALKALINE PHOSPHATASE; BETA GALACTOSIDASE; BILIRUBIN; CREATININE; ELECTROLYTE;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILIRUBIN BLOOD LEVEL; BLOOD SAMPLING; CONTROLLED STUDY; CORONARY ARTERY CIRCUMFLEX BRANCH; CREATININE BLOOD LEVEL; ECHOCARDIOGRAPHY; ELECTROLYTE BLOOD LEVEL; EXPRESSION VECTOR; FEMALE; GENE TRANSFER; HEART LEFT VENTRICLE WALL; HEART MUSCLE; INFLAMMATION; LEUKOCYTE COUNT; NONHUMAN; PRIORITY JOURNAL; SAFETY; SWINE; THORAX SURGERY; UREA NITROGEN BLOOD LEVEL; VIRUS RECOMBINANT;

ADENOVIRUSES, HUMAN; ANIMALS; BETA-GALACTOSIDASE; BLOOD CHEMICAL ANALYSIS; CORONARY CIRCULATION; FEMALE; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HEART VENTRICLES; INJECTIONS, INTRA-ARTERIAL; INJECTIONS, INTRAMUSCULAR; LEUKOCYTE COUNT; MYOCARDIUM; SWINE; SWINE, MINIATURE;

ADENOVIRIDAE; ANIMALIA; MAMMALIA; SUIDAE; SUS SCROFA;

EID: 0343813262     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Nabel EG. Gene therapy for cardiovascular disease. Circulation 1995; 91: 541-548.
2. O'Brien TX, Hunter JJ, Dyson E, Chien KR. Heart-to-heart: new approaches for gene transfer in the myocardium. Circulation 1991, 83: 2133-2136.
3. Schneider MD, French BA. The advent of adenovirus; gene therapy for cardiovascular disease. Circulation 1993; 88: 1937-1942.
4. Lin H et al. Expression of recombinant genes in myocardium in vivo after direct injection of DNA. Circulation 1990; 82: 2217-2221.
5. Kitsis RN et al. Hormonal modulation of a gene injected into rat heart in vivo. Proc Natl Acad Sci USA 1991; 88: 4138-4142.
6. Acsadi G et al. Direct gene transfer and expression into rat heart in vivo. New Biol 1991; 3: 71-81.
7. Buttrick PM et al. Behavior of genes directly injected into the rat heart in vivo. Circ Res 1992; 70: 193-198.
8. Von Harsdorf R et al. Gene injection into canine myocardium as a useful model for studying gene expression in the heart of large mammals. Circ Res 1993; 72: 688-695.
9. Gal D et al. Direct myocardial transfection in two animal models: evaluation of parameters affecting gene expression and percutaneous gene delivery. Lab Invest 1993; 68: 18-25.
10. Barr E et al. Efficient catheter-mediated gene transfer into the heart using replication-defective adenovirus. Gene Ther 1994; 1: 51-58.
11. Guzman RJ et al. Efficient gene transfer into myocardium by direct injection of adenovirus vectors. Circ Res 1993; 73: 1202-1207.
12. Kass-Eisler A et al. Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo. Proc Natl Acad Sci USA 1993; 90: 11498-11502.
13. French BA, Mazur W, Geske RS, Bolli R. Direct in vivo gene transfer into porcine myocardium using replication-deficient adenoviral vectors. Circulation 1994; 90: 2414-2424.
14. Henson D, Mufson MA. Myocarditis and pneumonitis with type 21 adenovirus infection: association with fatal myocarditis and pneumonitis. Am J Dis Child 1971; 121: 334-336.
15. Karjalainen J et al. Etiology of mild acute infectious myocarditis. Acta Med Scand 1983; 213: 65-73
16. Lemarchand P, Jones M, Yamada I, Crystal RG. In vivo gene transfer and expression in normal uninjured blood vessels using replication-deficient recombinant adenovirus vectors. Circ Res 1993; 72: 1132-1138.
17. Quantin B, Perricaudet LD, Tajbakhsh S, Mandel JL. Adenovirus as an expression vector in muscle cells in vivo. Proc Natl Acad Sci USA 1992; 89: 2581-2584.
18. Stratford-Perricaudet LD, Makeh I, Perricaudet M, Briand P Widespread long-term gene transfer to mouse skeletal muscles and heart. J Clin Invest 1992; 90: 626-630.
19. Engelhardt JF, Ye X, Doranz B, Wilson JM. Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. Proc Natl Acad Sci USA 1994; 91: 6196-6200.
20. Erzurum SC et al. Protection of human endothelial cells from oxidant injury by adenovirus-mediated transfer of the human catalase cDNA. Nucleic Acids Res 1993; 21: 1607-1612.
21. 1-antirrypsin cDNA to human endothelial cells. Proc Natl Acad Sci USA 1992; 89: 6482-6486.
22. Mühlhauser J et al. In vivo angiogenesis induced by recombinant adenovirus vectors coding either for secreted or nonsecreted forms of acidic fibroblast growth factor. Hum Gene Ther 1995; 6: 1457-1465.
23. 165 expressed by a replication-deficient recombinant adenovirus vector induces angiogenesis in vivo. Circulation Res 1995 (in press).
24. Spessot R, Inchley K, Hupel TM, Bacchetti S. Cloning of the herpes simplex virus ICP4 gene in an adenovirus vector: effects on adenovirus gene expression and replication. Virology 1989; 168: 378-387.
25. Kalderon D, Roberts BL, Richardson WD, Smith AE. A short amino acid sequence able to specify nuclear location. Cell 1984; 39: 499-509.
26. McGory WJ, Bautista DS, Graham FL. A simple technique for the rescue of early region 1 mutations into infectious human adenovirus type 5. Virology 1988; 163: 614-617.
27. Graham FL, Smiley J, Russell WC, Nairn R. Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J Gen Virol 1977; 36: 59-72.
28. Rosenfeld MA et al. In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium. Cell 1992; 68: 143-155.
29. Dannenberg AM, Suga M. Histochemical stains for macrophages in cell smears and tissue sections: β-galactosidase, acid phosphatase, non-specific esterase, succinic dehydrogenase, and cytochrome oxidase. In: Adams DO, Edelson PJ, Koren HS (eds). Methods for Studying Mononuclear Phagocytes. Academic Press: New York, 1981, pp 375-395.
30. Mastrangeli A et al. Diversity of airway epithelial cell targets for in vivo recombinant adenovirus-mediated gene transfer. J Clin Invest 1993; 91: 225-234.