Radiation induced cytochrome c release causes loss of rat colonic fluid absorption by damage to crypts and pericryptal myofibroblasts

Gut

Volumn 47, Issue 5, 2000, Pages 675-684

  Thiagarajah, J R ^a,b   Gourmelon, P ^a   Griffiths, N M ^a   Lebrun, F ^a   Naftalin, R J ^b   Pedley, K C ^b  

^a INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Cadherin; Colon; Cytochrome c; Myofibroblast; Pericryptal sheath; Radiation

Indexed keywords

ALPHA ACTIN; BETA CATENIN; CASPASE INHIBITOR; COBALT 60; CYTOCHROME C; FLUORESCEIN ISOTHIOCYANATE; UVOMORULIN;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; COBALT THERAPY; COLON MUCOSA; CONTROLLED STUDY; ENTEROPATHY; ENZYME RELEASE; INTESTINE CRYPT; MALE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; RADIATION ENTEROPATHY; RADIATION INJURY; RAT;

ANIMALS; CADHERINS; CASPASES; CELL ADHESION; COLLAGEN; COLON; CYTOCHROME C GROUP; DEXTRANS; DOSE-RESPONSE RELATIONSHIP, RADIATION; FIBROBLASTS; FLUORESCEIN-5-ISOTHIOCYANATE; INTESTINAL ABSORPTION; MALE; MICROSCOPY, CONFOCAL; RATS; RATS, WISTAR;

EID: 0033756374     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.47.5.675     Document Type: Article

References (41)

1. In vivo alterations of fluid and electrolyte fluxes in rat colon by gamma irradiation
2. Radiation-induced gastrointestinal death in the monkey
3. Radiosensitvity of a mesenchymal tissue. The pericryptal fibroblast sheath in the human rectal mucosa
4. Effect of low dose ionizing radiation on the murine pericryptal fibroblast sheath: Radiation damage in a mesenchymal system in vivo
5. Evidence from fuorescence microscopy and comparative studies that rat, ovine and bovine colonic crypts are absorptive
6. Concentration polarization of fluorescent dyes in rat descending colonic crypts: Evidence of crypt fluid absorption
7. Regional differences in rat large intestinal crypt function in relation to dehydrating capacity in vivo
8. Colonic pericryptal fibroblast sheath: Replication, migration and cytodifferentiation of a mesenchymal cell system in adult tissue. I. Autoradiographic studies of normal rabbit colon
9. A cellular reticulum of fibroblast-like cells in the rat intestine - Scanning and transmission electron-microscopy
10. Myofibroblasts. II. Intestinal subepithelial myofibroblasts
11. Immunodetection of connexins and cadherins in corneal fibroblasts and myofibroblasts
12. Cadherins and associated proteins
13. The importance of the E-cadherin-catenin complex in the maintenance of intestinal epithelial homoeostasis: More than intercellular glue?
14. Regional crypt function in rat large intestine in relation to fluid absorption and growth of the pericryptal sheath
15. Angiotensin II stimulated expression of transforming growth factor-beta1 in cardiac fibroblasts and myofibroblasts
16. Radiation induced apoptosis
17. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
18. Dismantling cell-cell contacts during apoptosis is coupled to a caspase-dependent proteolytic cleavage of beta-catenin
19. Extensive apoptotic death of rat colonic cells deprived of crypt habitat
20. Ordering of ceramide formation, caspase activation, and mitochondrial changes during CD95- and DNA damage-induced apoptosis
21. Attenuation of ischemia/reperfusion injury in rats by a caspase inhibitor
22. TNF-induced enterocyte apoptosis and detachment in mice: Induction of caspases and prevention by a caspase inhibitor, ZVAD-fmk
23. + flux of varying luminal hydraulic resistance in rat colon in vivo
24. E-cadherin and OB-cadherin mRNA levels in normal human colon and colon carcinoma
25. Matrix adhesion characteristics of corneal myofibroblasts
26. Differentiation repertoire of fibroblastic cells: Expression of cytoskeletal proteins as marker of phenotype modulations
27. Adult human colonic subepithelial myofibroblasts express extracellular matrix proteins and cyclooxygenase-1 and -2
28. Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis
29. Common regulation of apoptosis signaling induced by CD95 and the DNA-damaging stimuli etoposide and gamma-radiation downstream from caspase-8 activation
30. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
31. The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant
32. Mitochondrial and intracellular-free calcium regulation of radiation-induced apoptosis in human leukemic cells
33. Over-expression of Bcl-2 does not protect cells from hypericin photo-induced mitochondrial membrane depolarization, but delays subsequent events in the apoptotic pathway
34. Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c
35. Apaf-1, a human protein homologous to C-elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
36. The proteolytic procaspase activation network: An in vitro analysis
37. Modified absorptive and secretory processes in the rat distal colon after neutron irradiation: In vivo and in vitro studies
38. DNA fragmentation induced by a cytoplasmic extract from irradiated cells
39. Redistribution of activated caspase-3 to the nucleus during butyric acid-induced apoptosis
40. Extent and limitation of the control of nuclear apoptosis by DNA-fragmenting factor
41. Differential expression of bcl-2 in intestinal epithelia. Correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia