Ultrastructural instability of paired helical filaments from corticobasal degeneration as examined by scanning transmission electron microscopy

American Journal of Pathology

Volumn 149, Issue 2, 1996, Pages 639-651

  Ksiezak Reding, Hanna ^a   Tracz, Elizabeth ^a   Yang, Liang Sheng ^a   Dickson, Dennis W ^a   Simon, Martha ^b   Wall, Joseph S ^b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b BROOKHAVEN NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

POLYPEPTIDE; TAU PROTEIN;

AGED; ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; FEMALE; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; SCANNING ELECTRON MICROSCOPY; THIN FILAMENT; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BASAL GANGLIA; BASAL GANGLIA DISEASES; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; FETUS; HUMANS; IMMUNOBLOTTING; MALE; MICROSCOPY, ELECTRON, SCANNING TRANSMISSION; MOLECULAR WEIGHT; NEUROFILAMENT PROTEINS; TAU PROTEINS;

EID: 0030017110     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Grundke-Iqbal I, Iqbal K, Tung YC, Ouinlan M, Wisniewski HM, Binder LI: Abnormal phosphorylation of the microtubule-associated protein tau in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci USA 1986, 83:4913-4917
2. Greenberg SG, Davies P: A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis. Proc Natl Acad Sci USA 1990, 87:5827-5831
3. Ksiezak-Reding H, Morgan K, Weidenheim K, Mattiace LA, Liu WK, Yen SH, Davies P, Dickson DW: Ultrastructure and biochemical composition of paired helical filaments in corticobasal degeneration. Am J Pathol 1994, 145:1496-1508
4. Wakabayashi K, Oyanagi K, Makifuchi T, Ikuta F, Homma A, Homma Y, Horikawa Y, Tokiguchi S: Corticobasal degeneration: etiopathological significance of the cytoskeletal alterations. Acta Neuropathol 1994, 87:545-553
5. Tabaton M, Whitehouse PJ, Perry G, Davies P, Autilio-Gambetti L, Gambetti P: Alz 50 recognizes abnormal filaments in Alzheimer's disease and progressive supranuclear palsy. Ann Neurol 1988, 24:407-413
6. Flament S, Delacourte A, Verny M, Hauw J-J, Javoy-Agid F: Abnormal tau proteins in progressive supranuclear palsy: similarities and differences with the neurofibrillary degeneration of the Alzheimer type. Acta Neuropathol 1991, 81:591-596
7. Pollock NJ, Mirra SS, Binder LI, Hansen LA, Wood JG: Filamentous aggregates in Pick's disease, progressive supranuclear palsy, and Alzheimer's disease show antigenic determinants with microtubule-associated protein, tau. Lancet 1986, 2:1211
8. Murayama S, Mori H, Ihara Y, Tomonaga M: Immunocytochemical and ultrastructural studies of Pick's disease. Ann Neurol 1990, 27:394-405
9. Braak H, Braak E, Grundke-Iqbal I, Iqbal K: Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: a third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques. Neurosci Lett 1986, 65:351-355
10. Hauw J-J, Verny M, Delaere P, Cervera P, He Y, Duyckaerts: Constant neurofibrillary changes in the neocortex in progressive supranuclear palsy: basic differences with Alzheimer's disease and aging. Neurosci Lett 1990, 119:182-186
11. Hof PR, Bouras C, Perl DP, Morrison JH: Quantitative neuropathologic analysis of Pick's disease cases: cortical distribution of Pick bodies and coexistence with Alzheimer's disease. Acta Neuropathol 1994, 87:115-124
12. Mori H, Nishimura M, Namba Y, Oda M: Corticobasal degeneration: a disease with widespread appearance of abnormal tau and neurofibrillary tangles, and its relation to progressive supranuclear palsy. Acta Neuropathol 1994, 88:113-121
13. Feany MB, Dickson DW: Widespread cytoskeletal pathology characterizes corticobasal degeneration. Am J Pathol 1995, 146:1388-1396
14. Kidd M: Paired helical filaments in electron microscopy of Alzheimer's disease. Nature 1963, 197:192-193
15. Oyanagi K, Takahashi H, Wakabayashi K, Ikuta F: Large neurons in the neostriatum in Alzheimer's disease and progressive supranuclear palsy: a topographic, histologic, and ultrastructural investigation. Brain Res 1991, 544:221-226
16. Tokutake S, Oyanagi S: Mechanical instability of Pick bodies and their isolation in an intact form using urea solution. Neurosci Lett 1993, 163:15-18
17. Sparkman DR, Johnson SA, Hamrnon KM, Allison PM, White CL: Isolation of the insoluble straight fibrils of Pick's disease. J Neurol Sci 1987, 80:173-184
18. Kato S, Nakamura H: Presence of two different fibril subtypes in the Pick body: an immunoelectron microscopic study. Acta Neuropathol 1990, 81:125-129
19. Jellinger KA, Bancher C: Neuropathology. Progressive Supranuclear Palsy: Clinical and Research Approaches. Edited by I Litwan, Y Agid. New York, Oxford University Press, 1992, pp 44-88
20. Wischik CM, Crowther RA, Stewart M, Roth M: Subunit structure of paired helical filaments in Alzheimer's disease. J Cell Biol 1985, 100:1905-1912
21. Ksiezak-Reding H, Wall JS: Mass and physical dimensions of two distinct populations of paired helical filaments. Neurobiol Aging 1994, 15:11-19
22. Takauchi S, Hosomi M, Marasigan S, Sato M, Hayashi S, Miyoshi K: An ultrastructural study of Pick bodies. Acta Neuropathol 1984, 64:344-348
23. Goedert M, Spillantini MG, Potier MC, Ulrich J, Crowther RA: Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain. EMBO J 1989, 8:393-399
24. Goedert M, Jakes R: Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization. EMBO J 1990, 9:4225-4230
25. Kosik KS, Orecchio LD, Bakalis S, Neve RL: Developmentally regulated expression of specific tau sequences. Neuron 1989, 2:1389-1397
26. Butler M, Shelanski ML: Microheterogeneity of microtubule-associated tau proteins is due to differences in phosphorylation. J Neurochem 1986, 47:1517-1522
27. Matsuo ES, Shin RW, Billingsley ML, Van de Voorde A, O'Connor M, Trojanowski LQ, Lee VMY: Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau. Neuron 1994, 13:989-1002
28. Wiche G, Oberkanins C, Himmler A: Molecular structure and function of microtubule-associated proteins. Int Rev Cytol 1991, 124:217-273
29. Ksiezak-Reding H, Liu W-K, Yen S-H: Phosphate analysis and dephosphorylation of modified tau associated with paired helical filaments. Brain Res 1992, 597:209-219
30. Greenberg SG, Davies P, Schein JD, Binder LI: Hydrofluoric acid-treated tau-PHF proteins display the same biochemical properties as normal tau. J Biol Chem 1992, 267:564-569
31. Goedert M, Spillantini MG, Cairns NJ, Crowther RA: Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms. Neuron 1992, 8:159-168
32. Ksiezak-Reding H, Shafit-Zagardo B, Yen S-H: Differential expression of exons 10 and 11 in normal tau and tau associated with paired helical filaments. J Neurosci Res 1995, 41:583-593
33. Feany MB, Ksiezak-Reding H, Liu W-K, Vincent I, Yen S-H, Dickson DW: Epitope expression and hyperphos-phorylation of tau proteins in corticobasal degeneration: differentiation from progressive supranuclear palsy. Acta Neuropathol 1995, 90:37-43
34. Wisniewski HM, Wen GY: Substructure of paired helical filaments from Alzheimer's disease neurofibrillary tangles. Acta Neuropathol 1985, 66:173-176
35. Miyakawa T, Katsuragi S, Araki K, Hashimura T, Kimura T, Kuramoto R: Ultrastructure of neurofibrillary tangles in Alzheimer's disease. Virchows Arch B Cell Pathol 1989, 57:267-273
36. Pollanen MS, Markiewicz P, Bergeron C, Goh MC: Twisted ribbon structure of paired helical filaments revealed by atomic force microscopy. Am J Pathol 1994, 144:869-873
37. Ruben GC, Novak M, Edwards PC, Iqbal K: Alzheimer paired helical filaments, untreated and pronase digested, studied by vertical platinum-carbon replication and high resolution transmission electron microscopy. Brain Res 1995, 675:1-12
38. Wall JS, Hainfeld JF: Mass mapping with the scanning transmission electron microscope. Annu Rev Biophys Chem 1986, 15:355-376
39. Ksiezak-Reding H, Morgan K, Dickson DW: Tau immunoreactivity and SDS solubility of two populations of paired helical filaments that differ in morphology. Brain Res 1994, 649:185-196
40. Khachaturian ZS: Diagnosis of Alzheimer's disease. Arch Neurol 1985, 42:1097-1105
41. 8 in tau synthetic peptides and varies between native and denaturated tau proteins. Brain Res 1995, 697:63-67
42. Otvos L, Feiner L, Lang E, Shendrei GI, Goedert M, Lee VMY: Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396-404. J Neurosci Res 1994, 39:669-673
43. Goedert M, Spillantini MG, Jakes R, Rutherford D, Crowther RA: Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease. Neuron 1989, 3:519-526
44. Mercken M, Vandermeeren M, Lubke U, Six J, Boons J, Van de Voorde A, Martin J-J, Gheuens J: Monoclonal antibodies with selective specificity for Alzheimer tau are directed against phosphatase-sensitive epitopes. Acta Neuropathol 1992, 84:265-272
45. Zar JH: Biostatistical Analysis, ed 2. Englewood Cliffs, NJ, Prentice Hall, 1984
46. Perry G, Steward D, Friedman R, Manetto V, Autilio-Gambetti L, Gambetti P: Filaments of Pick's bodies contain altered cytoskeletal elements. Am J Pathol 1987, 187:559-568
47. Masliah E, Hensen LA, Quijada S, DeTeresa R, Alford M, Kauss J, Terry R: Late onset dementia with argyrophilic grains and subcortical tangles or atypical progressive supranuclear palsy? Ann Neurol 1991, 29: 389-396
48. Papasozomenos SC: Tau protein immunoreactivity in dementia of the Alzheimer's type. II. Electron microscopy and pathogenic implications: effects of fixation on the morphology of the Alzheimer's abnormal filaments. Lab Invest 1989, 60:375-389
49. Crowther RA: Straight and paired helical filaments in Alzheimer disease have a common structural unit. Proc Natl Acad Sci USA, 1991, 88:2288-2292
50. Kosik KS, Greenberg SM: Tau proteins and Alzheimer disease. Alzheimer Disease. Edited by RD Terry, R Katzman, KL Bick. New York, Raven Press, 1994, pp 335-344
51. Metuzals J, Robitaille Y, Houghton S, Gauthier S, Kang CY, Leblanc R: Neuronal transformations in Alzheimer's disease. Cell Tissue Res 1988, 252:239-248
52. Crowther RA, Wischik CM: Image reconstruction of the Alzheimer paired helical filament. EMBO J 1985, 4:3661-3665
53. Crowther RA: Review: structural aspects of pathology in Alzheimer's disease. Biochim Biophys Acta 1991, 1096:1-9
54. Furcinitti PS, van Oostrum J, Burnett RM: Adenovirus polypeptide IX revealed as capsid cement by difference images from electron microscopy and crystallography. EMBO J 1989, 8:3563-3570
55. Tracz E, Dickson DW, Hainfeld JF, Ksiezak-Reding H: The ultrastructure of paired helical filaments with Nano-Van, a novel negative stain reagent. Int Conf EM 1994, 13:675-676
56. Paulus W, Selim M: Corticonigral degeneration with neuronal achromasia and basal neurofibrillary tangles. Acta Neuropathol (Berl) 1990, 81:89-94
57. Morishima-Kawashima M, Hasegawa M, Takio K, Suzuki M, Titani K, Ihara Y: Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments. Neuron 1993, 10:1151-1160
58. Yang LS, Ksiezak-Reding H: Ubiquitination of tau differs in paired helical filaments from Alzheimer's disease and corticobasal degeneration. Mol Biol Cell 1995, 6:37a