Fractionation of rat hepatocyte subpopulations with varying metabolic potential, proliferative capacity, and retroviral gene transfer efficiency

Experimental Cell Research

Volumn 244, Issue 2, 1998, Pages 405-419

  Rajvanshi, Pankaj ^a   Liu, Delong ^a   Ott, Michael ^a   Gagandeep, Singh ^a   Schilsky, Michael L ^a   Gupta, Sanjeev ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Gene expression; Growth factor; Hepatocyte; Liver; Ploidy

Indexed keywords

DNA; GLUCOSE 6 PHOSPHATASE; GLYCOGEN; GROWTH FACTOR; SCATTER FACTOR;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL FRACTIONATION; CELL METABOLISM; CELL PROLIFERATION; CELL STRUCTURE; CELL SUBPOPULATION; DNA SYNTHESIS; GENE EXPRESSION; GENE TRANSFER; LIVER CELL; MALE; NONHUMAN; PLOIDY; PRIORITY JOURNAL; RAT;

EID: 0032213652     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1998.4223     Document Type: Article

References (45)

1. Yamauchi M., Potter J. J., Mezey E. Lobular distribution of alcohol dehydrogenase in the rat liver. Hepatology. 8:1988;243-247.
2. Bilir B. M., Gong T. W. G., Kwasiborski V., Shen C. S., Fillmore C. S., Berkowitz C. M., Gumucio J. J. Novel control of the position-dependent expression of genes in hepatocytes. The GLUT-1 transporter. J. Biol. Chem. 268:1993;19776-19784.
3. Wojcik E., Dvorak C., Chianale J., Traber P. G., Keren D., Gumucio J. J. Demonstration by in situ hybridization of the zonal modulation of rat liver cytochrome P-450b and P-450e gene expression after phenobarbital. J. Clin. Invest. 82:1988;658-666.
4. Ingelman-Sundberg M., Johansson F., Penttila K. E., Glaumann H., Lindros K. O. Centrilobular expression of ethanol-inducible cytochrome P-450 (IIE1) in rat liver. Biochem. Biophys. Res. Commun. 157:1988;55-60.
5. Berkowitz C. M., Shen C. S., Bilir B. M., Guibert E., Gumucio J. J. Different heptocytes express the cholesterol 7 α-hydroxylase gene during its circadian modulation in vivo. Hepatology. 21:1995;1658-1667.
6. Gumucio J., Bilir B. M., Moseley R. H., Berkowtiz C. M. The biology of the liver cell plate. The Liver: Biology and Pathobiology. 1994;Raven Press, New York. p. 1143-1163.
7. Cereghini S., Raymondjean M., Alejandro J. C., Herbomel P., Yaniv M. Factors involved in control of tissue-specific expression of albumin gene. Cell. 50:1987;627-638.
8. Tal M., Kahn B. B., Thorens B., Lodish H. F. Restricted expression of erythroid/brain glucose transporter isoform to perivenous hepatocytes in rats: Modulation by glucose. J. Clin. Invest. 86:1990;986-992.
9. Berthoud V. M., Iwanij V., Garcia A. M., Saez J. C. Connexins and glucagon receptors during development of rat hepatic acinus. Am. J. Physiol. 263:1992;G650-G658.
10. Kuo F. C., Darnell J. D. Jr. Evidence that interaction of hepatocytes with the collecting (hepatic) reins triggers position-specific transcription of the glutamine synthetase and ornithine aminotransferase genes in the mouse liver. Mol. Cell Biol. 11:1991;6050-6058.
11. Sigal S., Gupta S., Gebhard D. F. Jr., Holst P., Neufeld D., Reid L. M. Evidence for a terminal differentiation process in the rat liver. Differentiation. 59:1995;35-42.
12. Lemire J. M., Shiojiri N., Fausto N. Oval cell proliferation and the origin of small hepatocytes in liver injury induced by D-galactosamine. Am. J. Pathol. 139:1991;535-552.
13. Dabeva M. D., Murston E., Shafritz D. A. Transcription factor and liver-speicific mRNA expression in facultative epithelial progenitor cells of the liver and pancreas. Am. J. Phathol. 147:1995;1633-1648.
14. Golding M., Sarraf C., Lalani E. N., Alison M. R. Reactive biliary epithelium: The product of a pluripotent stem cell compartment. Hum. Pathol. 27:1996;872-874.
15. Wu P. C., Fang J. W., Lau V. K., Lai C. L., Lo C. K., Lau J. Y. Classification of hepatocellular carcinoma according to hepatocellular and biliary differentiation markers. Clinical and biological implications. Am. J. Pathol. 149:1996;1167-1175.
16. Sigal S. H., Brill S., Fiorino A. S., Reid L. M. The liver as a stem cell and lineage system. Am. J. Physiol. 263:1992;G139-G148.
17. Wagenaar G. T., Chamuleau R. A. F. M., de Haan J. G., Maas M. A. W., de Boer P. A. J., Marz F., Moorman A. F. M., Fredericks W. M., Lamers W. H. Experimental evidence that the physiological position of the liver within the circulation is not a major determinant of zonation of agene expression. Hepatology. 18:1993;1144-1153.
18. Brill S., Zvibel I., Reid L. M. Maturation-dependent changes in the regulation of liver-specific gene expression in embrynal versus adult primary liver cultures. Differentiation. 59:1996;95-102.
19. Brodsky W. Y., Uryvaeva I. V. Cell polyploidy: Its relation to tissue growth and function. Int. Rev. Cytol. 50:1977;275-332.
20. Schmucker D. L. Hepatocyte fine structure during maturation and senescence. Electron Microsc. Tech. 14:1990;106-125.
21. Beer D. G., Schwarz M., Sawada N., Pitot H. C. Expression of H-ras and c-myc protooncogenes in isolated gamma-glutamyl transpeptidase-positive rat hepatocytes and in hepatocellular carcinomas induced by diethylnitrosamine. Cancer Res. 46:1986;2435-2441.
22. Guerri C., Sancho-Tello M., Renau-Piqueras J., Baguena R. Effect of pre- and postnatal exposure to alcohol on perivenous and periportal neonatal rat hepatocytes. Alcohol Alcohol. 1987;277-282.
23. Sancho-Tello M., Renau-Piqueras J., Baguena-Cervellera, Cuerri C. A biochemical and stereological study of neonatal rat hepatocyte subpopulations. Effect of pre- and postnatal exposure to ethanol. Virchows Arch. B Cell. Pathol. Incl. Mol. Pathol. 54:1987;170-181.
24. Osypiw J. C., Allen R. L., Billington D. Subpopulations of rat hepatocytes separated by Percoll density-gradient centrifugation show characteristics consistent with different acinar locations. Biochem. J. 304:1994;617-624.
25. Rutenburg A. M., Kim H., Fischbein J W., Hanker J. S., Wasserkrug H. L., Seligman A. M. Histochemical and ultrastructural demonstration of gamma-glutamyl transpeptidase activity. Histochem. Cytochem. 17:1969;517-526.
26. Teusch H. F. Improved method for the histochemical demonstration of glucose-6-phosphatase activity, a methodological study. Histochemistry. 57:1978;107-117.
27. Bensley C. M. Comparison of methods for demonstrating glycogen microscopically. Stain. Technol. 14:1930;47-52.
28. Terada K., Manchikalapudi P., Noiva R., Jaurequi H. O., Stockert R. J., Schilsky M. L. Secretion surface localization turnover and steady state expression of protein disulfide isomerase in rat hepatocytes. J. Biol. Chem. 270:1995;20410-20416.
29. Haugen D. A., van der Hoeven T. A., Coon M. J. Purified liver microsomal cytochrome P-450 separation and characterization of multiple forms. J. Biol. Chem. 250:1975;3567-3570.
30. Coon M. J., Ding X., Pernecky S. J., Vaz A. D. Cytochrome P450: Progress and predictions. FASEB J. 6:1992;669-673.
31. Donato M. T., Gomez-Lechon M. J., Castell J. V. A microassay for measuring cytochrome P450IA1 and P450IIB1 activities in intact human and rat hepatocytes cultured on 96-well plates. Anal. Biochem. 213:1993;29-33.
32. Gupta S., LaBrecque D. R., Shafritz D. A. Mitogenic effects of hepatic stimulator substance on cultured nonparenchymal liver epithelial cells. Hepatology. 15:1992;485-4891.
33. Price J., Turner D., Cepko C. Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transfer. Proc. Natl. Acad. Sci. USA. 84:1987;156-160.
34. Lee C-C., Yamada K. M. Alternatively spliced juxtamembrane domain of a tryosine kinase receptor is a multifunctional regulatory site: Deletion alters cellular tyrosine phosphorylation pattern and facilitates binding of phosphatidylinositol-3-OH kinase to the hepatocyte growth factor receptor. J. Biol. Chem. 270:1995;507-510.
35. Braakman I., Keij J., Hardonk M. J., Meijer D. K. F., Groothuis G. M. M. Separation of periportal and perivenous rat hepatocytes by fluorescence-activated cell sorting: Confirmation with collodial gold as an exogenous marker. Hepatology. 13:1991;73-82.
36. Diez-Fernandez C., Bosca L., Fernandez-Simon L., Alvarez A., Cascales M. Relationship between genomic DNA ploidy and parameters of liver damage during necrosis and regeneration induced by thioacetamide. Hepatology. 18:1993;912-918.
37. Bohm N., Noltemeyer N. Excessive reversible phenobarbital induced nuclear DNA-polyploidization in the growing mouse liver. Histochemistry. 72:1981;63-74.
38. Gupta S., Rajvanshi P., Lee C-D. Integration of transplanted hepatocytes into host liver plates demonstrated by dipeptidyl peptidase IV-deficient rats. Proc. Natl. Acad. Sci. USA. 92:1995;5860-5864.
39. Rhim J. A., Sandgren E. P., Degen J. L., Palmiter R. D., Brinster R. L. Replacement of diseased mouse liver by hepatic cell transplantation. Science. 263:1994;1149-1152.
40. Overturf K., Muhsen A. D., Tanquay R., Brantly M., Ou C. N., Finegold M., Grompe M. Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinemia type I. Nat. Genet. 12:1996;266-273.
41. Rajvanshi P., Kerr A., Bhargava K. K., Burk R. D., Gupta S. Studies of liver repopulation using the dipeptidyl peptidase IV-deficient rat and other rodent recipients: Cell size and structure relationships regulate capacity for increased transplanted hepatocyte mass in the liver lobule. Hepatology. 23:1996;482-496.
42. Petersen J., Dandri M., Gupta S., Rogler C. E. Persistent hepadnavirus infection and clonal tumor growth in uPA/Rag-2 mice after liver repopulation with woodchuck hepatocytes. Proc. Natl. Acad. Sci. USA. 95:1998;310-315.
43. Block G. D., Locker J., Bowen W. C., Petersen B. E., Katyal S., Strom S. C., Riley T., Howard T. A., Michalopoulos G. K. Population expansion clonal growth and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF EGF and TGF-alpha in a chemically defined (HGM) medium. J. Cell. Biol. 132:1996;1133-1149.
44. Overturf K., Al-Dhalimy M., Ou C-N., Finegold M., Grompe M. Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes. Am. J. pathol. 151:1997;1273-1280.
45. Ott M., Stockert R. J., Ma Q., Gagandeep S., Gupta S. Simultaneous upregulation of viral receptor expression and DNA synthesis is required for increasing efficiency of retroviral hepatic gene transfer. J. Biol. Chem. 273:1998;11954-11961.