Bax and p53 differentially involved in the regulation of caspase-3 expression and activation during neurodegeneration in Lurcher mice

Comptes Rendus de l'Academie des Sciences - Serie III

Volumn 323, Issue 11, 2000, Pages 967-973

  Selimi, Fekrije ^a   Campana, Aline ^a   Weitzman, Jonathan ^b   Vogel, Michael W ^c   Mariani, Jean ^a  

^a SORBONNE UNIVERSITÉ   (France)

^b Institut Pasteur   (France)

^c MARYLAND PSYCHIATRIC RESEARCH CENTER   (United States)

Author keywords

Bax; Caspase 3; Granule cell; Lurcher; P53; Purkinje cell

Indexed keywords

CASPASE 3; PROTEIN BAX; PROTEIN P53;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME REGULATION; FEMALE; GRANULE CELL; HETEROZYGOSITY; MALE; MOUSE; MOUSE STRAIN; NERVE DEGENERATION; NONHUMAN; OLIVARY NUCLEUS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN INTERACTION; PURKINJE CELL; RECEPTOR UPREGULATION; TARGET CELL;

ANIMALIA;

EID: 0033710322     PISSN: 07644469     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0764-4469(00)01243-9     Document Type: Article

References (18)

1. Developmental changes in expression and distribution of the glutamate receptor channel delta 2 subunit according to the Purkinje cell maturation
2. Neurodegeneration in Lurcher mice caused by mutation in delta2 glutamate receptor gene
3. Structural and quantitative studies on the normal C3H and Lurcher mutant mouse
4. Target-related and intrinsic neuronal death in Lurcher mutant mice are both mediated by caspase-3 activation
5. Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis
6. BCL-2 family members and the mitochondria in apoptosis
7. Bax inactivation in lurcher mutants rescues cerebellar granule cells but not purkinje cells or inferior olivary neurons
8. Neurodegeneration in lurcher mice occurs via multiple cell death pathways
9. A role for the tumour suppressor gene p53 in regulating neuronal apoptosis
10. Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons
11. Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death
12. Mutation of a glutamate receptor motif reveals its role in gating and delta2 receptor channel properties
13. Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia
14. Transient global forebrain ischemia induces a prolonged expression of the caspase-3 mRNA in rat hippocampal CA1 pyramidal neurons
15. From PTK-STAT signaling to caspase expression and apoptosis induction
16. Overexpression of a Hu-bcl-2 transgene in Lurcher mutant mice delays Purkinje cell death
17. E2F1 mediates death of B-amyloid-treated cortical neurons in a manner independent of p53 and dependent on bax and caspase 3
18. Calpain and caspase: Can you tell the difference?