Clonal selection versus genetic instability as the driving force in neoplastic transformation

Cancer Research

Volumn 60, Issue 22, 2000, Pages 6510-6518

  Chow, M ^a   Rubin, H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL GROWTH; CELL STRAIN 3T3; GENETIC VARIABILITY; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

3T3 CELLS; ANIMALS; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; CLONE CELLS; MICE;

EID: 0033677321     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Clonal origin of human tumors
2. Clonal analysis of human colorectal tumors
3. Clonal origin of bladder cancer
4. Multiple head and neck tumors: Evidence for a common clonal origin
5. Genetic instabilities in human cancer
6. Mutator phenotype may be required for multistage carcinogenesis
7. Lessons from hereditary colorectal cancer
8. Genomic instability occurs in colorectal carcinomas but not in adenomas
9. Defects in mismatch repair occur after APC mutations in the pathogenesis of sporadic colorectal tumours
10. The mutation rate and cancer
11. Selection, the mutation rate and cancer: Ensuring that the tail does not wag the dog
12. Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines
13. Basis for the acquisition of malignant potential by mouse cells cultivated in vitro
14. Uniqueness of each spontaneous transformant from a clone of Balb 3T3 cells
15. Evidence for the progressive and adaptive nature of spontaneous transformation in the NIH 3T3 cell line
16. Relation of spontaneous transformation in cell culture to adaptive growth and clonal heterogeneity
17. Adaptive evolution of degrees and kinds of neoplastic transformation in cell culture
18. Genetic changes in epithelial solid neoplasia
19. Emergence of neoplastic transformants spontaneously or after exposure to N-methyl-N'-nitro-N-nitrosoguanidine in populations of rat liver cells cultured under selective and nonselective conditions
20. The cellular ecology of progressive neoplastic transformation: A clonal analysis
21. Coculturing diverse clonal populations prevents the early-stage neoplastic progression that occurs in the separate clones
22. Murine sarcoma and leukemia viruses: Assay using clonal lines of contact-inhibited mouse cells
23. Relation of the slow growth phenotype and neoplastic transformation: Possible significance for human cancer. In Vitro Cell
24. Improved medium and culture conditions for clonal growth with minimum serum protein and for enhanced serum-free survival of Swiss 3T3 cells. In Vitro Cell
25. Clonal dynamics of progressive neoplastic transformation
26. Heritable, population-wide damage to cells as the driving force of neoplastic transformation
27. Quantitative and qualitative studies of chemical transformation of cloned C3H mouse embryo cells sensitive to postconfluence inhibition of cell division
28. Clonal analysis of the expression of multiple transformation phenotypes and tumorigenicity by morphologically transformed 10T1/2 cells
29. Random, population-wide genetic damage induced in replicating cells treated with chemotherapeutic drugs
30. APC mutations are sufficient for the growth of early colorectal adenomas
31. Experimental control of neoplastic progression in cell populations: Foulds' rules revisited
32. Incipient and overt stages of neoplastic transformation
33. On the prevention and therapy of prostate cancer by androgen administration
34. Cellular adaptation in the origin and development of cancer
35. Chemical carcinogens and ras gene activation
36. N-nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras 1 gene mutations
37. Long-term administration of DDT or phenobarbital-Na in Wistar rats
38. Promotion of spontaneous preneoplastic cells in rat liver as a possible explanation of tumor production by nonmutagenic compounds
39. Spontaneous occurrence of γ-glutamyl transpeptidase-positive hepatcytic foci in 105-week-old and 72-week-old Fischer 344 male rats
40. The early stages of carcinogenesis by 20-methylcholanthrene in the skin of the mouse. II. Microscopic tissue changes
41. Histogenesis of DMH-induced colon neoplasms in the mouse
42. A natural somatic mutation frequency and human carcinogenesis
43. Somatic mutations are frequent and increase with age in human kidney epithelial cells
44. The onset and extent of genomic instability in sporadic colorectal tumor progression
45. Age-dependent induction of hepatic tumor regression by the tissue microenvironment after transplantation of neoplastically transformed rat liver epithelial cells into the liver
46. Age and the generation time of the mouse duodenal epithelial cell
47. A modified concept of consciousness
48. The development of transplantable teratocarcinomas from intratesticular grafts of pre- and post-implantation mouse embryos
49. Normal genetically mosaic mice produced from malignant teratocarcinoma cells
50. Cancer as a dynamic developmental disorder
51. Mismatch repair deficiency in phenotypically normal human cells
52. Transgenic mouse models for studying mutations in vivo: Applications in aging research
53. Genetically abnormal clones in histologically normal breast tissue